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  • Cyclosporine, sometimes referred to as "cyclsporin A," is an immunosuppresive agent produced by the soil fungus Beauveria nivia. It initially attracted the interest of the medical community in the management of organ transplant patients, as its mechanism of immune suppression is unique.
  • Cyclosporine is used to prevent rejection of kidney, liver, and heart transplants. It also is used investigationally to prevent rejection problems in bone marrow and other transplants.
  • Cyclosporine suppresses the immune system's T-cells. Both the T-helper cell and the T-suppressor cell may be affected. Cyclosporine also inhibits interleukins.
  • Cyclosporin may be used in combination with another immunosuppressant and a steroid medication. 
  • Cyclosporine is generally given once or twice daily depending on the disease being treated.
  • Sandimmune is a soft-gel capsule form of cyclosporine. Absorption from the intestinal tract can vary a lot and is incomplete. 
  • Cyclosporine is distributed largely outside the blood volume.
  • The production of a nanosuspension is the transformation of a macrosized powder into a mostly  aqueous nanosized suspension.
  • Cyclosporin A (CsA) is a cyclic oligopeptide that possesses imunomodulating properties and exhibits strong anti-allergic effects. The drug has been used in humans after organ transplantation, and in the last two decades in human dermatology for the treatment of psoriasis and AD. 
  • In the last few years, there is a growing interest in the use of CsA to treat canine skin diseases. The efficacy and safety of CsA for the treatment of AD in dogs was evaluated in several trials.
  • CsA at the dose of 5mg/kg was found to have mild adverse reaction, usually GI related, but otherwise was well tolerated.
  • Cyclosporine, used originally to prevent the rejection of transplanted kidneys, continues to be recommended for a variety of organ transplants. However, it has proven effective in treating people with rheumatoid arthritis who have not responded well to other medications as well as those with other rheumatic conditions and severe forms of psoriasis. 
  • Renal transplant biopsy is the gold standard for differentiating ailograft rejection from acute tubular necrosis and cyclosponne toxicity.
  • Side effects include high blood pressure, kidney damage, tremors, headaches, seizures, excessive hair growth, excessive gum growth, confusion, coma, and gout.
  • The demand for Cyclosporin in the U.S. market is estimated at $450 million. 
  • Introduction
  • About Cyclosporin
  • General Information
  • Patient Medication
  • Trade Names
  • Cyclosporin ophthalmic emulsion
  • Medication Manual
  • Cyclosporin- For Veterinary Information
  • Heart Transplant

Production And Processing

  • Production and characterisation by application of the optimised analytics 
  • Optimization of media composition for the production of Cyclosporin A by Tolypocladium species
  • Phospholipid-Stabilized Nanoparticles of Cyclosporine A by Rapid Expansion from Supercritical to Aqueous Solution
  • Process for manufacturing Cyclosporin a by highly productive fusant strain
  • Production of cyclosporins by Tolypocladium niveum strains
  • Mechanism of action of Cyclosporin or tacrolimus


  • Cyclosporin-A Enhances Docetaxel-Induced Apoptosis through Inhibition of Nuclear Factor-kB Activation in Human Gastric Carcinoma Cells
  • Nanostructured  Lipid drug Carriers
  • FDA panel knocks back inhaled Cyclosporin
  • Treatment of Cyclosporine-Induced Gingival Hypertrophy
  • Assessing New Technologies
  • Heart Transplantation
  • Liver Transplantation in Children
  • Drug Therapy in the heart Transplant Recipient


  • Cellular adaptations of skeletal muscles to Cyclosporin
  • Medical Applications
  • Prediction of Cyclosporine Dosage in Patients
  • Protective effects of Cyclosporin A on T-cell
  • Cyclosporin A in the treatment of Atopic dermatitis in dogs
  • Calcineurin Inhibitors: A Novel Approach to Canine Atopic Dermatitis 
  • Intradermal drug delivery by low frequency sonophoresis
  • A novel application of cyclosporineAin nonmyeloablative pretransplant


  • Cyrin
  • Cyclosporin Capsules
  • Gengraf Cyclosporin
  • Generic Capsules
  • Gengraf Capsules
  • Sandimmune Soft Gelatin Capsules
  • Neoral Capsules
  • Neoral Soft Gelatin Capsules
  • Panimun Bioral
  • Material Safety Data sheet


  • Cyclosporin A Suppliers
  •  Suppliers in China
  • Suppliers In Tradekey
  • ecplaza Suppliers
  • Sandimmune Neoral Suppliers
  • Tradeleads
  • Cyclosporin Manufacturers
Company Profiles And Plant details
  • Pharmaceutical Technology
  • Fujian Kerui Pharmaceutical Co., Ltd
  • NeuroPharma
  • Isotechnika Inc.
  • Eastpro Technology Inc
  • Poli Industria Chimica
  • Novartis
  • Paddock Laboratories Inc.
  • Syntetica Fine Chemicals Inc.
  • Adamed
  • Panacea Biotec
  • Lipid Technology

Consultants And Projects

  • D. Adu, MD, FRCP
  • American Physiological Society
  • Lachman Consultant Services Inc.,
  • Expert Consulting And Expert Witness Services
  • Michele Keane-Moore
  • Jo Prang-Medicap Pharmacy Center
  • Ophthalmic Consultants of Long Island
  • Margaret D.Allen
  • Management Of  Multifaceted Projects
  • Referential Projects In Pharmaceutical Industry


  • Cyclosporin-based pharmaceutical compositions
  • United states Patent- Microemulsion Concentrate Composition Cyclosporin
  • Pro-nanodispersion for the delivery of Cyclosporin
  • United States Patent- Liposome Mixture Containing Cyclosporin
  • Pharmaceutical composition comprising cyclosporin solid-state microemulsion


  • RPG Life to market Cyclosporin in US
  • Second Chiron plant has sterility problems
  • Immunosuppression Minimization: Current and Future Trends in Transplant Immunosuppression
  • Considering a Market in Human Organs
  • A Promising Immunosuppressive Agent
  • Global Pharmaceutical, Biotechnology & Medical Device Conference
  • Scope And Opportunities Of Contract Research Services In India


  • Allergan- 03 Annual Report
  • Brain Cyclosporine A Levels Are Determined By Ontogenic Regulation Of Mdr1a Expression
  • Cyclosporin whole blood immunoassays
  • Generic Version of Neoral Receives FDA Approval for Transplant Patients
  • Issues Analysis Report
  • The Transplant Revolution
  • 2002 Organ And Tissue Transplant Costs And Discussion
  • T-Cell Depletion/Cyclosporine Equal to Methotrexate/Cyclosporine

Safety issues And Guidelines

  • Drugs And Supplements
  • Chemical Database
  • Difficult Asthma
  • Medline Plus Information
  • Neoral Side Effects
  • Adult Nutrition Guidelines
  • Guidelines On Renal Transplantation.



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