- Common indication for heparin therapy is the prevention of blood
clot formation following major surgical procedures lasting longer than
30 minutes
- Heparin is used as an inject able anticoagulant. It is also
used to form an inner anticoagulant surface on various experimental and
medical devices such as test tubes and renal dialysis
machines.
- Generally, physicians prefer heparin over warfarin because heparin
has a rapid onset of anti-coagulant activity, a short physiological
half-life and significantly fewer incidences of drug-drug interactions.
These pharmacological properties facilitate dose adjustment and
contribute to Heparin’s relatively large margin of safety.
-
Unfractionated heparin is a large heterogenous molecule with a molecular
weight that can range from 5,000 to 30,000 daltons. Low molecular weight
heparins such as dalteparin, enoxaparin and tinzaparin range from 1,000
to 10, 000 daltons
- The affinity of polypeptides for
immobilized heparin has led to the purification, amino acid sequencing,
and molecular cloning of several mitogenic, angiogenic growth factors,
collectively known as heparin-binding growth factors .
- The biophysical functions depend
on the unique properties of GAGs : the ability to fill the space, bind
and organize water molecules and repel negatively charged molecules.
Because of high viscosity and low compressibility they are ideal for a
lubricating fluid in the joints.
- The non-leaching heparin
molecules are covalently bonded into the surface to provide similar
beneficial effects as heparan sulphate in the natural
endothelium.
- Heparanase is an enzyme involved
in extracellular matrix degradation and remodeling. Heparin and low
molecular weight heparin (LMWH) are anticoagulant agents currently used
in treatment of thrombotic disorders.
- Ribosomes can be removed by
ultracentrifugation in the presence of CDB prior to application to a
heparin column or separated by heparin affinity column itself as their
intact form.
- Heparin treatment has moved over
the last 20 years through three generations from natural heparin, to low
molecular weight heparins to synthetic heparin.
- Bioengineering has provided a cell line for producing heparin which
is closely related (in structure) to pharmaceutical grade heparin
-
Neutralase has been studied as a heparin reversal agent
- Platelet aggregation inhibitors
and heparins dominate the market, accounting for approximately 60% and
30% of total antithrombotic agent sales respectively. The US market
accounts for almost half of all global sales.
- Currently, worldwide heparin sales are estimated to be more than $4
billion, with a 15% yearly growth rate. The annual global market for
anticoagulant therapies is approximately $6 billion.
- Generic version of Synthetic Heparin is being launched in the North
American market in early 2008.
- The heparin market is dominated by LMWHs, 2005
|
General
- Heparin Basics
- Glycosaminoglycans
- Proteoglycans
- Heparin-Like
Glycosaminoglycans
- Heparin Injection
- Heparin Sodium
Injection
- Heparin-Livestock
Productions
- Biosynthesis of
Heparin
- Preparation of Lipoprotein
Lipase
- Production of
Heparin-Binding Angiogenic Factor
- Heparin Coating Process of
Oxygenators
- Preparation of
Heparin
- Production of Heparin
Binding Epidermal Growth Factor
- Purification and
Characterization of Novel Heparin
- NKF-Process
for Quality
- Novel Heparin Production
Method
- Analyses of Heparin
Preparations
Technology
- Coating Technologies
- CBAS Compendium
- Unique End-point
Attachment
- Gore Propaten Vascular
Graft
- Human
Factors Process Analysis
- Heparinex Technology
- Covalent Linking
Technology
- Momenta's
Technology
- Diagnosis of Heparin-Induced
Thrombocytopenia/Thrombosis
- Biointeracting Materials for
Medical Application
- Purification of Proteins Using Heparin
Affinity Column Chromatography
- Heparin
Characterization
United States
Patent
- Process of
Supersulfated Heparin
- Method to Produce Solid Form of
Heparin
- Heparin Or Derivative
- Preparing Mixed Heparin
Salts
- Heparins for Prevention of
Cerebral Edemas
- Medical Application for Heparin
- Non-Thrombogenic Material Reacted with
Heparin
Applications
- Effect of Heparin on Wound
Healing
- Heparin Bovine
Injection
- Nonanticoagulant Heparin
Prevents Coronary Endothelial Dysfunction
- Treatment of DVT
Products
- BIBA-HEPCOAT
- EpranEx
- T2T-Heparin Biocompatible Surfaces
- Heparin
Oligosaccharides
- Heparin Sodium
Products
Consultant
- Heparin Coating Process
Consulting Service
- Reginald J. Blaber
- Jeffrey Brock Riley
- John H Scurr
- Medical Consultants
- Roger Lauren Lundblad
- Tyler Cardiovascular
Consultants
|
Projects and Plant
- Aventis Enoxaparin Sodium
Manufacturing Plant
- Medimpex UK
- New Pharmaceutical Manufacturing
Plant in Singapore
- Antibodies Associated with
Heparin-Induced Thrombocytopenia
Safety
- Reducing Intravenous Heparin
Errors
- Safety Data for Heparin Sodium
Salt
- ReNcell VM Immortalized Cell
Line
- Heparin Sodium
Injection
- Safety of Perioperative Minidose
Heparin
- Heparin-MSDS
- Heparin Monitoring and Patient
Safety
- Porcine Heparin
- SafeCrit Hematocrit
Tubes
Guidelines
- Heparin Flush Injection
- Guide to Anticoagulant
Therapy
- Initial Treatment of
VTE
- Drug Guide-Heparin
- Heparin Injection
Guide
- Heparin Infusion Prior to
Stenting (HIPS) Trial
Reports
- Alchemia Financial
Report
- FDA Approval for
Arixtra
- GeneMedix-Financial
Review
- Heparin-Bonded
Circuit
- Probable Cutaneous Response to
Heparin
- Heparin- Induced
Thrombocytopenia Occurring
After Discontinuation of
Heparin
- Epidural Haematoma
- Heparin
in Baby Alan’s Case
- Treatment of Experimental Fat
Embolism with Heparin
- Uses of Heparin To Treat Burn
Injury
- Biological Standardization
of
Unfractionated Heparin
Market
- Alchemia Limited
- Emisphere
- Arixtra(R)
Receives Priority Review
- Cost-Effectiveness of
Low-Molecular Weight Heparin
- Heparanase Derived Peptides for
Coagulation
- Arixtra Accelerates
Manufacturers, Suppliers,
Exporters and Importers
- Heparin Manufacturers and
Suppliers
- Heparin Sodium
Suppliers
- Heparin Sodium
Exporters
- Heparin Exporters and
Manufacturers in India
- Leading Suppliers of
Heparin
- Heparin-Trade Leads
- Heparin Sodium Manufacturers and
Suppliers in US
- Heparin Importers
Company Profiles
-
IntelliHep
- TUA
Systems
- Carmeda
- Lifespan Technologies
- Emisphere
Technologies,Inc.
Order the
CD ROM Today |