- Betulin is an abundant
naturally occurring triterpene. It is commonly isolated from the bark of
birch trees and forms up to 30% of the dry weight of the extractive.
Betulin and betulinic acid are naturally occurring substances found in a
variety of plants but can be derived from the Birch and Plane trees in
high concentrations.
- Betulinic acid isn't
very poisonous, is relatively inexpensive, and is abundantly available
from the bark of white birch trees in the form of betulin. The compound
is presently undergoing preclinical development.
- Betulin, a powdery
substance in the outer bark of the birch tree, has been shown to help
wounds heal faster and cut inflammation. Betulin (> 98% purity) was
obtained from Stanislaw Piela, Sylveco, Jasionka, Poland. Chemists
identified betulin in bark some 200 years ago About 15 percent of birch
bark is betulin. Betulin and betulinic acid is 100% natural extract from
Birch bark.
- Betulinic acid is a
pentacyclic lupane triterpene, is a known natural compound with various
biological effects.It has several botanical sources, but can also be
chemically derived from betulin, a substance found in abundance in the
outer bark of white birch trees.Hydrolysis of 2d with ethanol–KOH at
refluxing temperature gave betulinic acid 2c in 89% yield.
- The purified betulin
was obtained by recrystallization from ethanol or isopropanol. Oxidation
of lupane triterpene betulin readily available from the birch bark by
bromine results in the oxidized form of bromoderivative.
- Traditional
ethnomedicine from around the world has used betulin containing trees in
the treatment of ailments that range from pneumonia and malaria to
syphilis, sterility and stomach aches.
- Betulin and betulin
derivatives may be useful in treating:Cadmium toxicity, HIV,Human
melanoma and has good prospects for their application in medicine and
pharmaceutics industry.
- Betulin and betulinic
acid, plant-derived triterpenoid compounds, have been described to
possess anti-inflammatory activity.
- Betulinic acid is an
attractive and promising new lead compound for use against human
melanoma and is currently undergoing preclinical development for
treatment or prevention of malignant melanoma.Betulinic acid, a
naturally occurring triterpene found in the bark of the white birch
tree, has been demonstrated to induce programmed cell death with
melanoma and certain neuroectodermal tumor cells.
- Betulin possesses
antiseptic, anti-virus, anti-inflammatory, hepatoprotective,
antioxidant, and other useful properties. Betulin has very competitive
price with high quality.
- The amounts of betulin
and betulin acid are of commercial quantity and greater than that found
in Midwestern birch
Betulin are frequently excavated in prehistoric
central and northern Europe can really be considered as birch bark
pitch.
- Betulinic acid is a
novel anticancer drug with specificity for neuroectodermal tumors
Quantity of betulin and betulinic acid are higher in the Alaska samples
than in eastern North American paper birch.
- In Russia, a company
has developed a method to isolate betulin from birch bark and has been
producing commercial quantities of the compound. The company currently
sells cosmetics and food supplements containing betulin in Europe and
Japan.
- The University of
Minnesota-Duluth’s Research Institute formed a partnership with an
energy company and a paper company to develop and patent a process that
would cost-effectively isolate pure betulin and other compounds from
birch bark in large quantities.
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General
Information
- Pharmacology of
Betulinic Acid
- Birch bark
Extract
- Betulin
- About Betulin
- The Giving Tree
Company
Profile
- Company from
California
- Company from
Russia
- Company from
Europe
- Company from
China
- Company from US
- China Company
- China Company from
Hangzhou
Consultant &
Project
- Consultant from
California
- Consultant from
USA
- Correlation of
cytotoxic activity of betulinines and their hydroxy analogues
- Study of
Chromatographic methods for Ginkgo Biloba and echinacea in food
supplements
- Novel Natural Product
based anti-anxiety therapy and natural insecticides
Production &
Extraction Process
- Isolation and Structure
Elucidation of Betulin and Other Compounds from Birch Bark
- Betulin Isolation from
Activated Birch-Bark and Testing of its Biological Activity
- Oxidizing Bromination
of Betulin
- Cost-Effective,
Proprietary Extraction of Betulin and Betulinic Acid from Birch
Bark
- Studies in organic
archaeometry III 1. Prehistoric adhesives: alternatives to birch bark
pitch2 could be ruled out
- Betulinic Acid
Suppresses Carcinogen-Induced NF- B Activation Through Inhibition of I B
Kinase and p65 Phosphorylation: Abrogation of Cyclooxygenase-2 and
Matrix Metalloprotease-9
- Synthesis of phthalates
of betulinic acid and betulin with cytotoxic activity
- Differential regulation
of soyasaponin and betulinic acid production by yeast extract in
cultured licorice cells
- Production of Betulin
and Fatty acid from Birch Bark
- Studies in organic
archaeometry III 1. Prehistoric adhesives: alternatives to birch bark
pitch2 could be ruled out
Applications
- Activation of
Mitochondria and Release of Mitochondrial Apoptogenic Factors by
Betulinic Acid
- Differential effect of
Betulin and Betulinic acid on Cytokine Production in Human Whole Blood
cell culture
- Synthesis of phthalates
of betulinic acid and betulin with cytotoxic activity
- Betulinic Acid-induced
Programmed Cell Death in Human Melanoma Cells Involves Mitogen-activated
Protein Kinase Activation
- Improvement of
Excretion Methods and Studying the Composition and Properties of Birch
Bark Extracts
- Reciprocal regulation
of eNOS and NADPH oxidase by betulinic acid in human endothelial
cells
- Simple synthesis of
allobetulin, 28-oxyallobetulin and related biomarkers from betulin and
betulinic acid catalysed by solid acids
- Synthesis of a New
Triterpenoid – Steroid Hybrid Molecule from Betulin
Patent &
Technology
- Antiangeogenic Activity
of Betulinic Acid and its derivatives
- Cosmetic Compositions
Containing Betulinic Acid
- Method of Preparing and
Use of Propdrugs of Betulinic Acid derivatives
- Extracting Betulinic
Acid from ZiZiphus Jujura
- Use of Betulinic Acid
and its Derivatives for Inhibiting Cancer Growth and a Method of
Monitoring this
- Use or Betulin and
Analogs Thereof to treat Herpes Virus Infection
- Method for
Manufacturing Betulinic Acid
- Process for Obtaining
Betulinic Acid
- Method for Producing
Betulinic Acid
- Determination of Major
Phenolic Acids, Phenolic Diterpenes and Triterpenes in Rosemary
(Rosmarinus officinalis L.) by Gas Chromatography and Mass
Spectrometry
|
Product & Material Safety
Data Sheet
- Betulahepat
- Betulair
- Betuline
- Betusil
- Chaga
- Diabetulin
- Betulin and Betulinic
Acid Bulk
- Superantitox
- Tubelon
- Betulin MSDS
Properties
- Birch Herb Description - Drug Interactions, Dosage and
Some of Its Useful Properties - Ayurveda
- Biological activity of
pentacyclic triterpenes
- Anticancer Properties
of Birch Bark Compounds
- In Vitro Cytotoxic
Properties of Grewia Tiliaefolia Bark Lupeol
- Phytochemical and
Antinociceptive Properties of Matayba elaeagnoides
Functions
- Anti-Human
Immunodeficiency Virus Activity of YK-FH312 (a Betulinic Acid
Derivative), a Novel Compound Blocking Viral Maturation
- Biologically active
pentacyclic triterpenes and their current medicine signification
- Betulinic Acid
Suppresses Carcinogen-Induced NF- B Activation Through Inhibition of I B
Kinase and p65 Phosphorylation: Abrogation of Cyclooxygenase-2 and
Matrix Metalloprotease-9
- Betulinic Acid Inhibits
Maturation of the Human Immunodeficiency Virus Type 1 Gag Precursor
Assembled In Vitro
- Betulinic Acid-induced
Mcl-1 Expression in Human Melanoma – Mode of Action and Functional
Significance
- In vitro evaluation of
the cytotoxic and trypanocidal activities of Ampelozizyphus
amazonicus
- Protective Effects of
Triterpene Compounds Against the Cytotoxicity of Cadmium in HepG2
Cells
Report &
Market
- Biotransformation of
the Antimelanoma Agent Betulinic Acid by Bacillus megaterium
- Chemical Constituents
from Terminalia glabrescens
- Luxenchalcone, a New
Bichalcone and other Constituents from Luxemburgia octandra
- Pharmacological
potential of Albizzia lebbeck: A Review
- Recent advances in the
discovery and development of plant-derived natural products and their
analogs as anti-HIV agents
- A Study to Investigate
the Potential for Development of Non-Timber Forest Products and Values
from the Boreal Forests of Newfoundland
and Labrador
- Annual Report on the
genetics of Wildlife
- Market in the
Raw
- Market and Product
Development for Birch Timber and Non-Timber Products: Current Status and
Potential in British Columbia
Suppliers
- China betulin
suppliers
- Selling Leads of
Betulin
- Global Suppliers of
Betulin
- Betulin
Suppliers
- Betulin
Exporters
- Trade Leads of
Betulin
- Manufacturer and
Suppliers of Betulin
- Betulin Selling
Leads
- Leading Suppliers of
Betulin
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