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  • Cytokines are small cell-signaling protein molecules that are secreted by the glial cells of the nervous system and by numerous cells of
    the immune system and are a category of signaling molecules used extensively in intercellular communication.
  • Cytokines can be classified as proteins, peptides, or glycoproteins; the term "cytokine" encompasses a large and diverse family of regulators produced throughout the body by cells of diverse embryological origin.
  • Cytokines have been classed as lymphokines, interleukins, and chemokines, based on their presumed function, cell of secretion, or target of action.
  • Cytokines are small secreted proteins which mediate and regulate immunity, inflammation, and hematopoiesis.
  • Cytokines and their receptors exhibit very high affinity for each other.
  • Cytokines regulate the intensity and duration of the immune response by stimulating or inhibiting the activation, proliferation, and/or differentiation of various cells and by regulating their secretion of Abs or other cytokines.
  • Cytokines are peptides that have a fundamental role in communication within the immune system and in allowing the immune system and host tissues cells to exchange information.
  • Immune function depends on the biologic activities of numerous small glycoprotein messengers, termed cytokines.
  • Cytokines are made by many cell populations, but the predominant producers are helper T cells (Th) and macrophages.
  • Cytokines play an important role in the understanding and treatment of diseases in many medical specialties.
  • Cytokines/immunocytokines, were initially used to separate the immunomodulatory proteins, also called immunotransmitters, from other growth factors that modulate proliferation and bioactivities of non-immune cells.
  • Some cytokines are produced by a rather limited number of different cell types while others are produced by almost the entire spectrum of known cell types.
  • Cytokines evolved from the earliest forms as intracellular molecules before the appearance of receptors and signaling cascades.
  • Cytokine-like activities have been demonstrated in invertebrates such as star fish and Drosophilia, where they played an essential role in host defense and repair.
  • Inflammation is mediated by a variety of soluble factors, including a group of secreted polypeptides known as cytokines.
  • Inflammatory cytokines can be divided into two groups: those involved in acute inflammation and those responsible for chronic inflammation.
  • Cytokines are a heterogeneous group of biologically active proteins or glycoproteins which regulate cell growth, differentiation and other functions.
  • They are soluble (non-antibody) mediators which are active in very small quantities.
  • The roles of cytokines in health and disease are likely to be complex.
  • In general, measurable amounts of cytokines are rarely found in body fluids of healthy individuals.
  • Cytokines are highly pharmacologically active and thus may be effective agents for modifying biological responses.
  • The clinical utility of protein-drugs, cytokines in particular, is generally low largely due to their short half-life in circulation.
  • Cytokines are small, mostly secreted proteins that were originally characterized as immune modulators but have subsequently been found to mediate a diverse array of functions in nonimmune tissues, including the central nervous system (CNS).
  • Cytokines are proteins of low molecular mass produced by leukocytes.
  • Cytokine production occurs in short bursts during the effector phase of the immune or inflammatory response.
  • Cytokines are pleotrophic proteins that coordinate the host response to infection as well as mediate normal,
    ongoing signaling between cells of nonimmune tissues, including the nervous system.
  • Recently, fluorescent anti-cytokine and anti-chemokine monoclonal antibodies have become very useful for the intracellular staining and multiparameter flow cytometric analysis of individual cytokine-producing cells within mixed cell populations.
  • Cytokines act as messengers both within the immune system and between the immune system and other systems of the body, forming an integrated network that is highly evolved in the regulation of immune responses.
  • The current market for protein drugs, including cytokines, is valued at over US$30 billion per year and includes Erythropoetin (EPO) at over US$1.5 million per year, Colony Stimulating Factors (GCSF) at over US$1.3 billion per year and Interleukin-2 at US$300 million per year.
  • In Previous Years, US sales of cytokines grew to $3.8 billion, largely driven by steep price increases.
  • Four kinds of cytokines are currently available: interferon (IFN)-α, IFN-β, IFN-γ and the interleukins.
  • IFN-β brands, indicated for multiple sclerosis (MS), are the biggest sellers in the cytokines markets, constituting 76% of the total sales of this sector.
  • Cytokines and growth factor related products in the multiplexed bead array market may represent approximately 60-70% of product revenues.
General Information
  • Cytokine General Information
  • Cytokines and inflammation and how they influence depression and various medical diseases
  • Function of Cytokines
  • Cytokines
  • Properties of Cytokines
  • A Primer on Cytokines: Sources, Receptors, Effects, and Inducers


  • Calcitriol and calcium regulate cytokine production and adipocyte
  • Alterations in Peripheral Blood Mononuclear Cell Cytokine Production in Response to Phytohemagglutinin in
    Multiple Sclerosis Patients
  • Cytokine production and modulation
  • Psychological Stress, Cytokine Production, and Severity of Upper Respiratory Illness
  • Modulation of Inflammation and Cytokine Production by
    Dietary (n-3) Fatty Acids
  • Inflammatory Cytokine Production Predominates in Early Lyme Disease in Patients with Erythema Migrans
  • Modulation of cytokines production, granzyme B and perforin in murine CIK cells by Ganoderma lucidum polysaccharides
  • Production and Function of Cytokines in Natural and Acquired Immunity to Candida albicans Infection
  • Activation of monocytes and cytokine production in
    patients with peripheral atherosclerosis obliterans
  • Production and Quality Control of Cytokine Products
    derived by Biotechnological Processes
  • Cytokine Production Regulating Th1 and Th2 Cytokines in Hemophagocytic Lymphohistiocytosis
  • Detecting intracellular cytokines in activated monocytes


  • The Acute Effects of Systemic Cytokines on Peripheral Nerve Function in Humans
  • Detecting intracellular cytokines in activated lymphocytes
  • Development, cytokine profile and function of human
    interleukin 17
  • Effects of Adipocyte-Derived Cytokines on Endothelial Functions
  • Historical insights into cytokines
  • Cytokines in acute and chronic inflammation
  • Novel Function of TNF Cytokines in Regulating Bone Marrow B Cell Survival
  • Structure and function of cytokines receptors
  • Cytokines in immune function and sleep regulation
  • The Role of T Helper 2 Cytokines and their Receptors
  • Combination of Two Cytokine Inhibitors Reduces Nucleus Pulposus
  • Influence of cytokine inhibitors on concentration and activity of MMP-1 and MMP-3 in disc herniation
  • Combination benefit of traetment with the cytokine inhibitors interleukin receptor antagonist and PEGylated soluble tumor necrosis factor receptor type I in animal models of Rheumatoid Arthritis


  • Low levels of circulating inflammatory cytokines
  • Cytokines and liver regeneration after partial portal vein ligation in porcine experimental model
  • In Vitro Study Of Cytokine-mediated Activation of Endothelial Cell Permeability
    Using BD Falcon™ Cell Culture Inserts
  • Cytokines and NASH: A Pilot Study of the Effects of
    Lifestyle Modification and Vitamin E
  • Role of cytokines in experimental arthritis
  • A Preliminary Study of Cytokines in Suicidal and Nonsuicidal Adolescents with Major Depression
  • Cytokine kinetics
  • In vivo studies on cytokine involvement during acute viral respiratory disease of swine


  • Cytokine
  • Hybrid cytokines
  • Cytokine design
  • Cytokine binding domain of cytokine receptors
  • Human cytokine receptor
  • Mouse cytokine receptor
  • Cytokine restraining agents
  • Mammalian cytokine complexes
  • Purified cytokine inhibitory factor
  • Method for measuring endogenous cytokines
  • Inhibition of cytokine production
  • Cytokine Inhibitors
  • Use of cytokine inhibitors

Company Profiles

  • Company from California
  • Company from Florida
  • Company from Germany
  • Company from New Jersey
  • Company from US
  • Another company from California


  • Consultant from Germany
  • Consultant from Germany
  • Consultant from Germany
  • Consultant from USA
  • Consultant from USA
  • Consultant from UK
  • Consultant from UK


  • Cytokine Assay Instruction Manual
  • Cytokine ELISA Trouble Shooting Guide
  • BD Cytometric Bead Array
    (CBA) Human Inflammatory
    Cytokines Kit
  • Intracellular cytokine staining resource guide


  • Introduction to cytokines
  • Cytokines and Thelper subsets
  • Cytokines and Chemokines
  • Cytokines- essential to cell-cell communication
  • Cytokines study
  • Identification of Cytokine SNPs Using LightCycler
    Hybridization Probes and Melting Curve Analysis
  • Analysis and isolation of cytokine secreting cells
  • Differential cytokine profiles in juvenile idiopathic arthritis subtypes revealed by cluster analysis
  • A Cytokine Analysis of the Effect of Cell Saver on Blood in Coronary Bypass Surgery
  • Immunofluorescent Staining of Intracellular Cytokines for Flow Cytometric Analysis
  • Multiplex Analysis of Cytokines in Exhaled
    Breath Condensate
  • Analysis of TH1 and TH2 cytokine production in
    low grade B cell gastric MALT-type lymphomas stimulated in vitro with Helicobacter pylori
  • Analysis of Cytokine Dynamics in Corneal Allograft Rejection


  • Cytokines in cancer pathogenesis and cancer therapy
  • Design and application of a cytokinereceptor- based interaction trap
  • Measurement of protein cytokines in tissue extracts by
    enzyme-linked Immunosorbent assays
  • The Application of Cytokine
    Therapy Following TKI
  • Cytokines may be associated with Cognitive Function in Heart Failure
  • The role of cytokines in both the normal and malignant ovary
  • The Role of Pro-infl ammatory
    Cytokines in Memory Processes and Neural Plasticity
  • Detection of Intracellular Cytokines in T Lymphocytes using the BD FastImmune™ Assay on the BD FACSVerse™ System
  • Cytokines and anti-cytokines as therapeutics — An update


  • Multiplexed cytokine measurements using protein microarray technology
  • Novel Method of Monitoring Trace Cytokines and Activated STAT Molecules in the Paws of Arthritic Mice using Multiplex Bead Technology
  • Cytokine Detection In Culture Media Containing 10% FBS – A Comparison Of Two Commonly Used Homogeneous High Throughput Assay Technologies
  • Accurate Multiplex Cytokine Assay Developed with VeraCode® Technology


  • Cytokine Stabilization buffer
  • CellGro® GMP Cytokines
  • SOCS-3 (human) (rec.) (His)
  • Cytokine Data Sheet
  • Human Cytokine 30-Plex
  • MACS GMP Cytokines
  • TaqMan® Cytokine Gene
    Expression Plate I

Material Safety Data Sheet

  • Product Line BExxxxx
    Cytokines / Adhesion Molecules ELISA
  • Cytokine Stabilization Buffer
  • Cytokine Genotyping Products
  • Evidence Cytokine Array IV Test Kit
  • Pharmacology of Cytokines
  • Cytokine Array III (Evidence)


  • Behavioral Effects of Cytokines
  • Effects of cytokines and infections on brain neurochemistry
  • Differential Cytokine Effects on Primitive (CD34+CD38 -)
    Human Hematopoietic Cells
  • Effects of cytokines on mycobacterial phagosome maturation
  • Complex cytokine effects in a complex autoimmune disease
  • Effects of growth factors and
    cytokines on osteoblast


  • Executive Summary
  • Cytokines and Growth Factors: A Market Study
  • What’s fueling the biotech engine—2009–2010
  • Positive Study Results with Drug Compound MP1031 Promise New Therapeutic Options
  • Chemical Synthesis and Engineering of
    Cytokines of Potential Therapeutic Interest
  • An evaluation of cytokine capture nanoparticle technology: Stepping from bench space in to potential markets


  • Connecting cytokines and brain -current issues
  • Modulation of Cytokine Expression by Traditional Medicines
  • Cytokines and Cognition
  • Cytokines and CNS Development
  • A Pilot Study of Combined Suicide/Cytokine Gene
    Therapy in Two Patients with End-Stage Anaplastic
    Thyroid Carcinoma
  • Cytokine Signalling functions of human soluble IgE receptors in peripheral blood mononuclear cells from normal and hyper allergic individuals and in B-Lymphoblastoid and monocytic cell
  • Seventh WHO informal consultation on standards for cytokines, growth factors and endocrinological substances
  • Cytokine Therapies
    and Inhibitors: A Vibrant Pipeline and Active
    Approved Market


  • Suppliers of cytokines
  • Cytokines Selling Leads

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