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  • Mannitol or hexan-1,2,3,4,5,6-hexol (C6H8(OH)6) is an osmotic diuretic agent and a weak renal vasodilator. It is a sorbitol isomer. It was originally isolated from manna, and may also be referred to as Mannite and Manna Sugar. Chemically, mannitol is a sugar alcohol, or a polyol; it is similar to xylitol or sorbitol. However, mannitol has a tendency to lose a hydrogen ion in aqueous solutions, which causes the solution to become acidic.
  • Mannitol can also be used to open the blood-brain barrier by temporarily shrinking the tightly coupled endothelial cells that make up the barrier. This makes mannitol indispensable for delivering various drugs directly to the brain (e.g. in the treatment of Alzheimer's disease).
  • Mannitol is also used as a sweetener for people with diabetes. Since mannitol has a negative heat of solution, it is used as a sweetener in "breath-freshening" candies, the cooling effect adding to the fresh feel. In doses larger than 20g, mannitol acts as a laxative, and is sometimes sold as a laxative for children.It is sometimes used as an adulterant or cutting agent for heroin, methamphetamines or other illicit drugs. In popular culture, when it is used in this manner, it is often referred to as baby laxative.
  • Mannitol is commonly used in the circuit prime of a heart lung machine during cardiopulmonary bypass (CPB)The presence of mannitol preserves renal function during the times of low blood flow and pressure, while the patient is on bypass. The solution prevents the swelling of endothelial cells in the kidney, which may have otherwise reduced blood flow to this area and resulted in cell damage.
  • Mannitol is also being developed by an Australian pharmaceutical company as a treatment for cystic fibrosis and bronchiectasis and as a diagnostic test for airway hyperresponsiveness. The mannitol is orally inhaled as a dry powder through what is known as an osmohaler. The critical component of the mannitol being the particle size distribution (PSD). The company has marketing approval for its diagnostic in Austalia and Europe and is currently applying for approval from the FDA.
  • Global sales of food additives are estimated to be worth around USD22bn a year. Based on growth rates in the different sectors across
    the market, it is estimated that the total additives market grew at a rate of around 2.4% per annum between 2001 and 2004. Flavours remains the most important additive category, with sales at an estimated USD6bn in 2004.
  • Value growth in certain areas is being affected by price cuts as cheaper Asian products flood the international market and this is holding value growth back to a greater or lesser extent for vitamins, sweeteners and acidulants.
  • In terms of market growth since 2001, the most significant value increases per annum were seen in fat replacers (up 6.8% per annum), emulsifiers (up 5.6%), antioxidants (up 3.7%) and hydrocolloids (up 3.2%). However, within the additives market, price changes are particularly prevalent, and were largely responsible for the much lower growth in vitamins, sweeteners, and acidulants, despite continued healthy volume growth in all of these categories.
 General Information
  • Mannitol
  • Mannitol Ingredients
  • China Mannitol
  • Characteristics of Mannitol
  • Manna from heaven
  • Mannose Alcohol

Production and Processing

  • Production of Mannitol
  • Metabolic Engineering of Mannitol Production in Lactococcus lactis
  • Production of the Hexitol D-Mannitol by Cryptococcus neoformans
  • Overproduction of Heterologous Mannitol 1-Phosphatase
  • Production of D-Mannitol and Glycerol by Yeasts
  • Production Process of Mannitol

Company Profiles

  • Cargill
  • Enco Engineering GMBH
  • Guangxi Nanning Chemical Pharmaceutical Co., Ltd
  • Lianyungang zhongda seaweed industrial Co,.Ltd
  • Marker Gene Technologies, Inc
  • Palatinit
  • Roquette's Pharmaceutical & Cosmetics Business Unit
  • ABS Food Technology
  • Corn Products Specialty Ingredients
  • Zhejiang Huakang Enterprises Co., Ltd
  • Jasmin Corporation
  • Zuchem Inc
  • SPI Pharma

Consultants and Project

  • Cpl Business Consultants
  • Polyols Information Source
  • David Graham Patriquin
  • Experts in Mannitol
  • Fellman, John Keegan
  • Fred F. Telischi
  • Hector E. James
  • Jack G. Kleinman
  • Michael L. McManus
  • Stefan K. Piechnik
  • Mannitol production by lactic acid bacteria
  • Manitol as a treatment to clear airway mucus
  • Mannitol Project

Applications

  • Uses of Mannitol
  • Production of NADPH Using Mannitol
  • Uses of Mannitol for Monitoring Gill Permeability
    Changes in the Rainbow Trout
  • Manufacturing of Aspirin Using Mannitol
  • Medicinal Uses of Mannitol
  • Mannitol used for the Cultivation of Slow-growing Rhizobium
  • Mannitol for Resuscitation in Acute Head Injury
  • Effects of mannitol on the postreperfusion syndrome during orthotopic liver transplantations

Products

  • Mannogem 2080 Granular Mannitol
  • Mannitol Medication
  • Osmitrol
  • Mannitol Products
  • Mannitol Vitamin B12
  • Vitamin B-12
Technology and Patent 
  • Process Development For Mannitol Production
    by Lactic Acid Bacteria
  • Water Stress Induced by Mannitol and Sodium Chloride in Soybean Cultivars
  • Process for the production of mannitol
  • Fermentative production of mannitol
  • Novel monoglyceride lipase and its production process
  • Method for making mannitol with Lactobacillus intermedius
  • Manufacturing Process of Hard Coating Preparation
  • Lyophilized Beads Containing Mannitol
  • Method and Installation for the Crystallization of Mannitol
  • Powdered Mannitol
  • Process for Production D-Mannitol
  • Production of Mannitol
  • Process for Preparing Pulverulent Mannitol
  • Separation of Mannitol from Galactitol
  • Use of Mannitol

Market

  • SPI Pharma Market
  • Global GM Market about Mannitol
  • Mannitol Global Trends and Developments
  • Pharma Mail Market
  • United Kingdom Sugar Market
  • Mannitol method to slash price for low cal sugar replacer
  • China Market for Mannitol

Material Safety Data Sheet

  • Mannitol
  • Isotol
  • Mannitol Injection
  • D-Mannitol
  • Mannitol Reagent
  • Mannitol  Reagent A.C.S
  • Safety data for mannitol
  • Science Lab DataSheet

Report

  • ZuChem launches first mannitol sweetener
  • New manufacturing process can double HIV vaccine production
  • CRC Mannitol Annual Report
  • Roquette patents mannitol excipient
  • Quarterly Report to Shareholders
  • SPI Pharma responds to Roquette's patent

Manufacturers, Suppliers and Buyers

  • A.B.Enterprises
  • Mannitol Exporters
  • LYG Sodium Alginate Co., Ltd
  • Manufacturers of Mannitol
  • Sellers of Mannitol
  • Selling Leads of Mannitol
  • Suppliers of Mannitol
  • Trade Leads of Mannitol
  • Mannitol Buyers List

 Safety and Guides

  • Precaution Method of Mannitol
  • Guidelines of Mannitol
  • Side Effects of Mannitol
  • Warning to Use Mannitol

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