Octamethylcyclotetrasiloxane
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Octamethylcyclotetrasiloxane (D4) is an odorless, colorless
non-oily silicone fluid used primarily to make other silicone
materials.
- During this
manufacturing process, virtually all of the material is consumed,
with only a tiny amount of D4
remaining.
- In a small
handful of personal care products,D4 can be used as an additive
providing certain application-related benefits preferred by
consumers.
- Cyclic
dimethylsiloxane tetramer D4
tetracyclomethicone, Siloxane,octamethylcyclotetra
Siloxanes and Silicones octamethylcyclotetra Siloxanes
octamethylcyclotetra-Octamethylcyclotetrasiloxane
Octamethylcyclotetrasiloxane, Cyclo(octamethyl)tetrasiloxane
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Octamethylcyclotetrasiloxane (OMCTS), a common constituent of
household products, triggers the transformation of bismuth to the
volatile toxic derivative trimethylbismuth by methanosarcina
barkeri,
- Which is a
representative member of the sewage sludge microflora.
- Comparative studies
with the ionophores monensin and lasalocid,
- Which induce
effects similar to those observed for indicated that the stimulation
of bismuth methylation is not specific for the siloxane and
suggested that the stimulation observed is mainly due to facilitated
membrane permeation of the metal ion
- The cyclic siloxane
octamethylcyclotetrasiloxane and the linear siloxane
hexamethyldisiloxane have numerous industrial and consumer
applications and thus have the potential for human exposure.
- The present study was
undertaken to examine potential estrogenic and antiestrogenic
activities of D4 and HMDS
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Octamethylcyclotetrasiloxane or D4 is a low molecular weight
siloxane (LMWS) fluid with a low surface tension, low aqueous
solubility, high lipid solubility, and low vapor pressure
- It is present at
40-60% by weight in personal care products such as antiperspirants,
cosmetics, and hair care products
- Because of its
widespread use in these products, a typical woman is exposed to an
average daily intake (ADI) of 0.158 mg/kg/day
(11.1 mg/day) of D4 from daily use of such products bioavailability,
breast implant, D4, implantation, inhalation,
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Octamethylcyclotetrasiloxane, PBPK, physiologically based
pharmacokinetic model, risk assessment, silicone
- Synthetic
silicon-containing compounds (silicones) are usedin a variety of
consumer products, e.g., skin care products, antiperspirants,
antacids, and antiflatulence agents
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Octamethylcyclotetrasiloxane is a base fluid in a number of personal
care products, with excellent spreading and lubrication properties
and unique volatility characteristics.
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Octamethylcyclotetrasiloxane can be used in bath oils,
deodorants, skin creams, lotions, suntan and shaving products, nail
polishes.
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Octamethylcyclotetrasiloxane has faster drying time in low voc
formulate in hair sprays
- There is potential for
human exposure to cyclic siloxanes by the respiratory route.
- To determine the
pharmacokinetics of octamethylcyclotetrasiloxane (D4), a
material commonly found in personal care products, the respiratory
intake and uptake of D4 were measured in 12 healthy volunteers on
two occasions.
- The deposition in
continuous wave (cw) mode was compared with pulsed conditions
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General
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Bioavailability of
octamethylcyclotetrasiloxane
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Public consultation meeting
on proposed measures for octamethylcyclotetrasiloxane
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Octamethylcyclotetrasiloxane
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Octamethylcyclotetrasiloxane compound summary
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Potential estrogenic and ant
estrogenic activity of the cyclic siloxane
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Octamethylcyclotetrasiloxane
description
Uses
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Acute respiratory exposure
human volunteers octamethylcyclotetrasiloxane
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Appendix of the screening
assessment for the challenge
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Effect of
octamethylcyclotetrasiloxane on methylation of bismuth by
methanosarcina barkeri
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556-67-2 use of
octamethylcyclotetrasiloxane(d4)
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International chemical
safety cards
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Octamethylcyclotetrasiloxane
bmse000765 - data
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Octamethylcyclotetrasiloxane-based, low-permittivity
organosilicate coatings
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Route-specific differences
in distribution characteristics of octamethylcyclotetrasiloxane in
rats analysis using models
MSDS
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Antifoam af
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Csl 502 / silicone potting
and encapsulating sealant
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Enhance-plus
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Lotioncrafter lc995
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Nuflex® 302 high temperature
gasket making silicone sealant
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3c85-0
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Octamethylcyclotetrasiloxane
sc-250610
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Dow corning(r) 244 fluid
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Siltech s-701
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Ges waterford plant
260 hudson river rd
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Silco incorporated
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Waterford plant
260 hudson river rd
waterford ny 12188
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Momentive performance
material
260 hudson river
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Octamethylcyclotetrasiloxane
spectrum
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Scientific committee on
consumer products
sccp
opinion
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Specialty cleanerproducts
Patent
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Process for producing
octamethylcyclotetrasiloxane
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Method of polymerizing
silicone fluid
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Treated silica for oil
absorption
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Methods for preparing
decamethyl cyclopentasiloxane
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Cosmetic composition
comprising at least two volatile linear alkanes and at least one
nonprotein cationic polymer
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Octamethylcyclotetrasiloxane
azeotropes
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Silicones for power
treatment powers having surface treated with said silicones and
cosmetic materials containing said powers
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Cosmetic composition
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Preparation of triethyl
dimethyl siloxalane
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Cosmetic material
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Method for wash-protecting
the color of artificially dyed keratin fibers
Study
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Bioavailability of ctamethylcyclotetrasiloxane (d4) after
exposure to silicones by inhalation and implantation
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Environmental risk assessment report:
octamethylcyclotetrasiloxane
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Identification of metabolites of octamethylcyclotetrasiloxane (d4)
in rat urine
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Microbial degradation of octamethylcyclotetrasiloxane
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Percutaneous absorption studies of octamethylcyclotetrasiloxane
using the human skin/nude mouse model.
Technical consultant
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An
overview of volatile methylsiloxane (vms)* fluids
in the environment
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Proposed risk management approach for cyclotetrasiloxane, octamethyl-(d4)
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Disposition of radioactivity in fischer 344 rats after single and
multiple inhalation
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Dongyue chemical group
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Neural network modelling of the equilibrium
anionic polymerization of cyclic
siloxanes
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Induction of hepatic xenobiotic metabolizing enzymes in female
fischer-344 rat following
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Suppliers
- Suppliers of China
- Suppliers of China 1
- Suppliers of China 2
- Suppliers list of
China
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Octamethylcyclotetrasiloxane Suppliers
- Suppliers of Usa
- Suppliers of Usa
1
Company
profiles
- Company from China
- Company from
China 1
- Company from
China 2
- Company from
China 3
- Company from Usa
- Company from Usa 1
Market
- 2009-2010 chinese
octamethylcyclotetrasiloxane industrial special investigation
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Octamethylcyclotetrasiloxane cas556-67-2 research report 2012
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Octamethylcyclotetrasiloxane 556-67-2)
- China market report of
octamethylcyclotetrasiloxan
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Octamethylcyclotetrasiloxane (d4) market
- Global market report
of octamethylcyclotetrasiloxane
Mapping of chemical substances in consumer products
Report
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Consultation document
octamethylcyclotetrasiloxane
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Engo consolidated report on
public consultation meeting on proposed risk management
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An overview of volatile
methylsiloxane fluids in the environment
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Human health effects
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Physiological modeling
reveals novel pharmacokinetic behavior for inhaled octamethylcyclo
tetrasiloxane in rat
Process
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Biological process
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Bis(trifluoromethane)
sulfonimide initiated ring-opening polymerization of
octamethylcyclotetrasiloxane
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Octamethylcyclotetrasiloxane
catabolic process to dimethylsilanediol
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Dose-response modeling of
cytochrome p450 induction in rats by octamethylcyclotetrasiloxane
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Removal process of
octamethylcyclotetrasiloxane from biogas
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Screening
assessment for the challenge
Toxity
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A two-generation
reproductive toxicity study of octamethylcyclotetrasiloxane in rats
exposed by whole-body vapor inhalation.
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Acute respiratory exposure
of human volunteers to octamethylcyclotetrasiloxane
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Evaluation of
octamethylcyclotetrasiloxane as an induce of rat hepatic microsomal
cytochrome p450
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Genetic toxicity evaluation
of octamethylcyclotetrasiloxane.
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Modeling of human dermal
absorption of octamethylcyclotetrasiloxane
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Quantitative exposure of
humans to an octamethylcyclotetrasiloxane
Properties
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Composition and functional
properties of organosilicon plasma polymers from
hexamethyldisiloxane and octamethylcyclotetrasiloxane
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Properties of current molecule
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Octamethylcyclotetrasiloxane chemical
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Octamethylcyclotetrasiloxane 0310
Product
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Octamethylcyclotetrasiloxane
basic information
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Scientifique france co.ltd
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Octamethylcyclotetrasiloxane
98% 25 g
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Octamethylcyclotetrasiloxane
98% 100 g
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Octamethylcyclotetrasiloxane: sc-250610
Equipments suppliers
- Apsd4
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Dimethylsiloxane cyclic tetramer
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Information suppliers of
octamethylcyclotetrasiloxane
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Jamson
Pharama chem technology
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Alfa aesar
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Screening assessment for the challenge
octamethylcyclotetrasiloxane
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Sarchem laboratories, inc
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Shandong dongyue
silicone material co., ltd
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