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Project at a Glance Contents on the CD ROM
  • Octamethylcyclotetrasiloxane  (D4) is an odorless, colorless non-oily silicone fluid used primarily to make other silicone materials.
  • During this manufacturing process, virtually all of the material is consumed, with     only   a tiny amount of D4 remaining.
  •  In a small handful of personal care products,D4 can be used as an additive providing certain application-related benefits preferred by consumers.
  • Cyclic dimethylsiloxane     tetramer D4 tetracyclomethicone,   Siloxane,octamethylcyclotetra  Siloxanes and Silicones octamethylcyclotetra Siloxanes octamethylcyclotetra-Octamethylcyclotetrasiloxane Octamethylcyclotetrasiloxane, Cyclo(octamethyl)tetrasiloxane
  • Octamethylcyclotetrasiloxane (OMCTS), a common constituent of household products, triggers the transformation of bismuth to the volatile toxic derivative trimethylbismuth by methanosarcina barkeri,
  • Which is a representative member of the sewage sludge microflora.
  • Comparative studies with the ionophores monensin and lasalocid,
  •  Which induce effects similar to those observed for indicated that the stimulation of bismuth methylation is not specific for the siloxane and suggested that the stimulation observed is mainly due to facilitated membrane permeation of the metal ion
  • The cyclic siloxane octamethylcyclotetrasiloxane   and the linear siloxane hexamethyldisiloxane have numerous industrial and consumer applications and thus have the potential for human exposure.
  • The present study was undertaken to examine potential estrogenic and antiestrogenic activities of D4 and HMDS
  • Octamethylcyclotetrasiloxane or D4  is a low molecular weight siloxane (LMWS) fluid with a low surface tension, low aqueous solubility, high lipid solubility, and low vapor pressure
  • It is present at 40-60% by weight in personal care products such as antiperspirants, cosmetics, and hair care products 
  • Because of its widespread use in these products, a typical woman is exposed to an average daily intake (ADI) of 0.158 mg/kg/day
    (11.1 mg/day) of D4 from daily use of such products bioavailability, breast implant, D4, implantation, inhalation,
  • Octamethylcyclotetrasiloxane, PBPK, physiologically based pharmacokinetic model, risk assessment, silicone
  • Synthetic silicon-containing compounds (silicones) are usedin a variety of consumer products, e.g., skin care products, antiperspirants, antacids, and antiflatulence agents
  • Octamethylcyclotetrasiloxane is a base fluid in a number of personal care products, with excellent spreading and lubrication properties and unique volatility characteristics.
  • Octamethylcyclotetrasiloxane   can be used in bath oils, deodorants, skin creams, lotions, suntan and shaving products, nail polishes.
  • Octamethylcyclotetrasiloxane has faster drying time in low voc formulate in hair sprays
  • There is potential for human exposure to cyclic siloxanes by the respiratory route.
  • To determine the pharmacokinetics of octamethylcyclotetrasiloxane   (D4), a material commonly found in personal care products, the respiratory intake and uptake of D4 were measured in 12 healthy volunteers on two occasions.
  • The deposition in continuous wave (cw) mode was compared with pulsed conditions
  • Bioavailability of octamethylcyclotetrasiloxane
  • Public consultation meeting on proposed measures for octamethylcyclotetrasiloxane
  • Octamethylcyclotetrasiloxane
  • Octamethylcyclotetrasiloxane  compound summary
  • Potential estrogenic and ant estrogenic activity of the cyclic siloxane
  • Octamethylcyclotetrasiloxane description


  • Acute respiratory exposure   human volunteers octamethylcyclotetrasiloxane
  • Appendix of the screening assessment for the challenge
  • Effect of octamethylcyclotetrasiloxane on methylation of bismuth by methanosarcina barkeri
  • 556-67-2 use of octamethylcyclotetrasiloxane(d4)
  • International chemical safety cards
  • Octamethylcyclotetrasiloxane 
    bmse000765 - data
  • Octamethylcyclotetrasiloxane-based, low-permittivity
    organosilicate coatings
  • Route-specific differences in distribution characteristics of octamethylcyclotetrasiloxane in rats analysis using  models


  • Antifoam af
  • Csl 502 / silicone potting and encapsulating sealant
  • Enhance-plus
  • Lotioncrafter lc995
  • Nuflex® 302 high temperature gasket making silicone sealant
  • 3c85-0
  • Octamethylcyclotetrasiloxane
  • Dow corning(r) 244 fluid
  • Siltech s-701
  • Ges waterford plant
    260 hudson river rd
  • Silco incorporated
  • Waterford plant
    260 hudson river rd
    waterford ny 12188
  • Momentive performance material
    260 hudson river
  • Octamethylcyclotetrasiloxane spectrum
  • Scientific committee on consumer products
  • Specialty cleanerproducts


  • Process for producing octamethylcyclotetrasiloxane
  • Method of polymerizing silicone fluid
  • Treated silica for oil absorption
  • Methods for preparing decamethyl cyclopentasiloxane
  • Cosmetic composition comprising at least two volatile linear alkanes and at least one nonprotein cationic polymer
  • Octamethylcyclotetrasiloxane azeotropes
  • Silicones for power treatment powers having surface treated with said silicones and cosmetic materials containing said powers
  • Cosmetic composition
  • Preparation of triethyl dimethyl siloxalane
  • Cosmetic material
  • Method for wash-protecting the color of artificially dyed keratin fibers


  • Bioavailability of  ctamethylcyclotetrasiloxane (d4) after exposure to silicones by inhalation and implantation

  • Environmental risk assessment report:

  • Identification of metabolites of octamethylcyclotetrasiloxane (d4) in rat urine

  • Microbial degradation of octamethylcyclotetrasiloxane

  • Percutaneous absorption studies of octamethylcyclotetrasiloxane using the human skin/nude mouse model.

Technical consultant

  • An overview of volatile methylsiloxane (vms)* fluids in the environment
  • Proposed risk management approach for cyclotetrasiloxane, octamethyl-(d4)
  • Disposition of radioactivity in fischer 344 rats after single and multiple inhalation
  • Dongyue chemical group
  • Neural network modelling of the equilibrium
    anionic polymerization of cyclic siloxanes
  • Induction of hepatic xenobiotic metabolizing enzymes in female fischer-344 rat following
  • Suppliers of China
  • Suppliers of China 1
  • Suppliers of China 2
  • Suppliers list of China
  • Octamethylcyclotetrasiloxane Suppliers
  • Suppliers of Usa
  • Suppliers of  Usa 1

Company profiles

  • Company from China
  • Company  from China 1
  • Company  from China 2
  • Company  from China 3
  • Company from Usa
  • Company from Usa 1
  • 2009-2010 chinese octamethylcyclotetrasiloxane industrial special investigation 
  • Octamethylcyclotetrasiloxane cas556-67-2 research report 2012
  • Octamethylcyclotetrasiloxane 556-67-2)
  • China market report of octamethylcyclotetrasiloxan
  • Octamethylcyclotetrasiloxane (d4) market
  • Global market report of octamethylcyclotetrasiloxane
    Mapping of chemical substances in consumer products


  • Consultation document
  • Engo consolidated report on public consultation meeting on proposed risk management
  • An overview of volatile methylsiloxane  fluids in the environment
  • Human health effects
  • Physiological modeling reveals novel pharmacokinetic behavior for inhaled octamethylcyclo tetrasiloxane in rat


  • Biological process
  • Bis(trifluoromethane) sulfonimide initiated ring-opening polymerization of octamethylcyclotetrasiloxane
  • Octamethylcyclotetrasiloxane catabolic process to dimethylsilanediol
  • Dose-response modeling of cytochrome p450 induction in rats by octamethylcyclotetrasiloxane
  • Removal process of octamethylcyclotetrasiloxane from biogas
  • Screening assessment for the challenge


  • A two-generation reproductive toxicity study of octamethylcyclotetrasiloxane in rats exposed by whole-body vapor inhalation.
  • Acute respiratory exposure of human volunteers to octamethylcyclotetrasiloxane
  • Evaluation of octamethylcyclotetrasiloxane as an induce of rat hepatic microsomal cytochrome p450
  • Genetic toxicity evaluation of octamethylcyclotetrasiloxane.
  • Modeling of human dermal absorption of octamethylcyclotetrasiloxane
  • Quantitative exposure of humans to an octamethylcyclotetrasiloxane


  • Composition and functional properties of organosilicon plasma polymers from hexamethyldisiloxane and octamethylcyclotetrasiloxane
  • Properties of current molecule
  • Octamethylcyclotetrasiloxane chemical
  • Octamethylcyclotetrasiloxane 0310


  • Octamethylcyclotetrasiloxane basic information
  • Scientifique france co.ltd
  • Octamethylcyclotetrasiloxane
    98% 25 g
  • Octamethylcyclotetrasiloxane
    98% 100 g
  • Octamethylcyclotetrasiloxane: sc-250610

Equipments suppliers

  • Apsd4
  • Dimethylsiloxane cyclic tetramer
  • Information suppliers of octamethylcyclotetrasiloxane
  • Jamson Pharama chem technology
  • Alfa aesar
  • Screening assessment for the challenge
  • Sarchem laboratories, inc
  • Shandong dongyue silicone material co., ltd


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