Paracetamol
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  • Paracetamol is a painkiller, more technically described as a non-opioid analgesic. As a painkiller, it's similar in strength to aspirin, but does not have the anti-inflammatory action of aspirin.
  • Paracetamol is thought to work by blocking the production of chemicals, known as prostaglandins, which are involved in pain transmission. But, unlike aspirin and non steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, it blocks them in the brain not at the source of pain.
  • Paracetamol can be taken in tablet, capsule or liquid form, and is also available as suppositories. Paracetamol can be bought without a prescription from pharmacies and (in packs of up to 16 tablets) from other shops. It's vital that you always take it in the doses recommended on the packet. The recommend dose for adults is 500mg to 1000mg every 4-6 hours (one to two standard tablets), up to a maximum of 4000mg (8 tablets) in 24 hours.
  • Side effects are rare with paracetamol when it is taken at the recommended doses. Skin rashes, blood disorders and acute inflammation of the pancreas have occasionally occurred in people taking the drug on a regular basis for a long time. One advantage of paracetamol over aspirin and NSAIDs is that it doesn't irritate the stomach or causing it to bleed, potential Side effects of aspirin and NSAIDs.
  • Paracetamol is often contained in branded pain relieving products (see list below) and cough and cold remedies. These also often contain other painkillers such as codeine and other ingredients such as caffeine or a decongestant.
  • The early commercial production of paracetamol relied on the nitration of phenol to p-nitrophenol with a reduction step to produce p-aminophenol followed by acetylation with acetic anhydride.
  • In the UK, sales of over-the-counter Paracetamol in pharmacies are restricted to packs of 32 tablets per customer per occasion (only 16 tablets in non-pharmacy stores). In Ireland, the limits are 24 and 12 tablets respectively.
  • Liquid preparations of paracetamol are expensive
  • Tablets are a much cheaper form of paracetamol than liquid preparations, and some brands of paracetamol tablets are very much cheaper than others (the brands listed in the Schedule of Pharmaceutical Benefits tend to be less expensive).
  •  Content Headlines on CD ROM

    General
    • Tylenol
    • Drug Metabolic Interactions
    • Paracetamol Background Information
    • Pharmaceutical Solid Acetaminophen Doped Thermal Behavior
    • Supercritical Fluids

    Products and Tablet Formulations

    • Acetaminophen D.C Grade
    • Paracetamol Powder BP2002/USP26
    • Calpol Six Plus Sugar Free Suspension
    • Paracetamol Products
    • Paracetamol 500
    • Tablet Formulations Compression and Mechanical Properties
    • Pregelatinization of Starch Binders
    • Comparison of Granule and Tablet Properties

    Technology

    • Crystallization
    • Various Paracetamol Manufacturing Technologies
    • Process Analytical Technology Applications
    • Pharmaceutical Technology Report
    • Crystallo-co-Agglomeration Technique
    • Contract Manufacturing
    • Pharmaceutical Patents
    • US Patent:6,028,222

    Guidelines and Regulatory Issues

    • PRODIGY Quick Reference Guide
    • Acetaminophen Overdose
    • Safe Acetaminophen (Tylenol) Use
    • A Dancer's Guide To Pain Relief
    • Acetaminophen Poisoning
    • Alka-Seltzer XS
    • DCGI
    • Paracetamol Regulations

    Projects, Reports and Reviews

    • Paracetamol Project Brief
    • Project of 12500tons/Year of Paracetamol Raw Medicine
    • Granules India Report
    • Oral Liquid Paracetamol-Ireland
    • Project Know how Reports
    • Paracetamol Orthorhombic Polymorph Article
    • Non-Prescription Analgesics Review
    • Paracetamol-Induced Oxidative Stress in Rats
    Equipment, Raw Material and Formulation Manufacturers and Suppliers
    • Paracetamol Cone blender Machine Manufacturers and Suppliers in India
    • Granulator Machinery Manufacturers and Suppliers
    • Powders/Granules Manufacturers and Suppliers-India
    • Powder Manufacturers-China
    • Mass Mixer Machinery Manufacturers and Suppliers
    • Tray Drying Oven Machine Manufacturers and Suppliers-India
    • Pharmaceutical Packaging Machinery Suppliers-China
    • Tabletting Machine Manufacturers and Suppliers-India
    • Strip Packing Machine Suppliers-India
    • TOSC International-Pharmaceutical Formulations Manufacturers
    • Trade Leads
    • Paracetamol Powder Buyers

    Marketing and Cost Estimation

    • Pharmaceutical Sector-India
    • Anti-Dumping Investigations Concerning Import of Paracetamol from China and Taiwan
    • Paracetamol Market Reports
    • Masters Marketing-Price List
    • Drug Costs
    • Pacific Pharma Generics - Price List
    • CNS Market Outlook to 2010

    Company Overview

    • PFI Compresso Brochure
    • Drugs and Pharmaceuticals
      Industry Highlights
    • Formulation Challenges
    • Power Handling
    • Röhm Pharma Polymers
    • Global Channel
    • Rochem International

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