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  • Phytase is an enzyme that can break down the undigestible phytic acid (phytate) part found in grains and oil seeds and thus release digestible phosphorus, calcium and other nutrients. The enzyme phytase is normally produced (endogenous phytase)in ruminants.
  • Phytase has been isolated and characterized from cereals such as triticale, wheat, maize, barley and rice and from beans such as navy beans, mung beans, dwarf beans and California small white beans. Phytase activity has also been detected in white mustard, potato, radish, lettuce, spinach, grass and lily pollen.
  • The pH optimum of phytases vary from 2.2 to 8. Most microbial phytases, especially those of fungal orgin, have a pH optimum between 4.5 and 5.6. In contrast to most fungal phytases, A.fumigatus phytase has a broad pH optimum; at least 80% of the maximal activity is observed at pH values between 4.0 and 7.3. Some bacterial phytases, especially those from Bacillus, have a pH optimum at 6.5 - 7.5. The pH optima of plant seed phytases range from 4.0 to 7.5, most having an optimum between 4.0 and 5.6. The temperature optima of phytases vary from 45 to 77oC.
  • Phytate also reduces the digestibility of proteins, starch and lipids; inhibits enzymes such as a-amylase, trypsin, tyrosinase, etc. This is due to the chelating property of the substrate with the multivalent cations such as Zn2+, Fe2+, Ca2+, Mg2. Thus the presence of phytic acid in animal feeds is generally undesirable. Improved utilization of phosphorus present in phytate by animals can be met by supplementing phytase to the animal feed.
  • Phytase is an acid phosphohydrolase which hydrolyzes phophomonoester bonds from phytate, thereby liberating inorganic phosphates. This improves digestibility and nutritive value of feeds as well as reduces the phosphorus output from animal waste, thus controlling the environmental pollution. Phytases are classified as the family of histidine acid phosphatases and are found primarily in plants and microorganisms.
  • Phytate is known to form complexes with proteins at both acidic and alkaline pH. This interaction may affect changes in protein structure that can decrease enzymatic activity, protein solubility and proteolytic digestibility.
  • Phytase is used as an animal feed supplement to enhance the nutritive value of plant material by liberation of inorganic phosphate from phytic acid (myo-inositol hexakisphosphate) and, thereby, to reduce environmental phosphorus pollution.
    Phytase can be purified from transgenic microbes. Phytase has been produced recently in transgenic canola, alfalfa and rice plants. Phytase can also be massively produced through cellulosic biomass fermentation using genetically modified (GM) yeast.
  • The US is a key market for feed phosphates, a vital feed additive for healthy and strong animals. However, US demand for feed phosphates continues to trend modestly lower due to food health issues, improvements in animal genetics, better use of scientifi c research in formulating feeds, the use of phytase to better utilize nutrients in grain and rising availability of DDGS  , a by-product of ethanol production.
  • The industrial enzyme market is divided into three application segments: technical enzymes, food enzymes, and animal feed enzymes. The growth of animal feed enzymes is somewhat higher, expected to be close to 4% AAGR, helped in large part by increased use of phytase enzyme to fight phosphate pollution.
  • The phytase market is estimated to be worth more than $200 million, growing at a rate of over 5% per annum. Danisco Animal Nutrition entered this market 4 years ago with a new generation phytase - Phyzyme XP, developed under a strategic alliance with Diversa Corporation. Phyzyme XP is proven to be substantially more effective in the animal than traditional phytases.
 General Information
  • Phytase
  • Alfalfa Phytase
  • Phytase a Natural Enzyme
  • Phytase Fact Sheet
  • Phytic Acid

Production and Processing

  • Production of the Enzyme Phytase from Bacillus
  • Survey of Microorganisms for the Production of Extracellular Phytase
  • Novel Phytase from Bacillus subtilis
  • Submerged and Solid-State Phytase Fermentation
    by Aspergillus niger
  • Production of Phytase in a Low Phosphate Medium by a Novel Yeast Candida
  • Production of Two Types of Phytase from Aspergillus oryzae
  • Production Process of Phytase
  • Influence of Three Phytase Preparations in Broiler Diets Based on Wheat or Corn

Functions and Properties

  • Phytase: Basics of Enzyme Function
  • Functional Properties of Enzyme
  • Biophysical Characterization of Fungal Phytases
  • Properties of  Phytase
  • Properties of Wheat Bran Properties
  • Purification and Properties of Extracellular Phytase
    from Bacillus
  • Effects of Microbial Phytase Supplementation on Feed Consumption
  • Effect of Phytase and Zinc Supplementation on Palm Kernel Cake Toxicity in Sheep

Company Profiles

  • AB Enzymes
  • Biocon
  • Equichem International, Inc
  • GuangZhou Wisdom Feed Technology Co., Ltd
  • Maps
  • Novozymes
  • Specialty Enzymes and Biochemicals Co.
  • Sunson Industry Group Co., Ltd
  • Advanced Enzyme Technologies Ltd

Consultants

  • Mark Eric Cook
  • Joaquim Brufau De Barbera
  • James S. Diana
  • Maykay Orgill
  • Vegard Denstadli
  • CPL Business Consultants
  • Jane Emily Hill

Applications

  • Phytase for Food Application
  • Application of microbial phytase in fish feed
  • Application of Bacterial Phytase
  • Dietary Phytase: An ideal approach for a cost
    effective and low-polluting aquafeed
  • Nutrient Use of Phytase in Broiler Chicks
  • Uses of Phytase Hydrolyzing Enzyme in Animal Food
  • Uses of Phytase in Paultry Manure and Manure-Amended Soils
  • Adding Phytase Proves Positive for Poultry, Swine Diet
  • Use of Phytase in Pig and Poultry Feed to Reduce Phosphorus Excretion
  • Practical Use of Feed Enzymes for Turkeys and Broilers
  • Efficacy of an E. coli phytase in yeast for releasing phytate-boundphosphorus in young chicks and pigs
  • Phytase application in Poultry Feed

Product and Material Safety Data Sheet

  • Quantum™ Phytase
  • Ronozyme
  • Nutri-Phytase-2000
  • Smizyme
  • Phytic Acid
  • Phytase
Technology
  • Industrial Enzyme Technology
  • Phytase Fermentation Technology
  • New Phytase Enzyme to Benefit the Environment, Natural Resources, and Nutrition
  • ARS Technology Transfer
  • Nutrition Technology  for Animal Feed Production Solutions

Patent 

  • Phytase
  • Modified phytases
  • Phytase variants
  • Phytase and gene encoding said phytase
  • Peniophora phytase
  • Phytase polypeptides
  • Fermentation with a phytase
  • Thermotolerant phytase for animal feed
  • Phosphatases with improved phytase activity
  • Production Process of Phytase
  • Phytase enzymes, nucleic acids encoding phytase enzymes
  • Recombinant phytases and uses thereof

Project

  • Alkaline phytase from lily pollen
  • Evaluate and Optimize Dietary Phytase Enzymes Production and Utilization in Animal Nutrition
  • Thermostable phytase production by Thermoascus aurantiacus in submerged fermentation
  • Influence of the addition of phytase to a diet on bone in growing and pregnant pigs
  • Microbial phytase and its impact on protein and energy utilisation in pigs and poultry
  • Phytase production from Pseudomonas putida harbouring Escherichia coli
  • Fate of Microbial Phytase in the Gastrointestinal Tract

Market

  • Feed Market Analysis Report
  • Global Market for Industrial Enzymes to Reach $2.4 Million by 2009
  • Danisco Animal Nutrition and Diversa  Granted FDA Approval for New Phytase
  • JBS United Launches New Product For Pork, Poultry Producers
  • New generation phytases help minimize feed costs and the environmental impact of swine production
  • New coating technology offers unrivalled phytase thermostability and performance
  • Phytase Current Market Situation

Report

  • Syngenta Agricultural News
  • Summary of Phytase
  • Phytase Demand for Animal Feed
  • Summary of Phytase Studies for Channel Catfish
  • Phytase Annual Report
  • Effect of Citric Acid, Phytase, and Their Interaction on Gastric pH
  • The Value of Improving Phosphorous Retention
  • Substitution of Phytase for Inorganic Phosphorous for Turkey Hens
  • Dietary Phosphorus Levels For Market Pigs
  • Phytase Sources
  • Phytase Can Replace Trace Mineral Premix

Manufacturers, Suppliers and Buyers

  • Trade Leads of Phytase
  • Manufacturers of Phytase
  • Nutritek
  • Phytase Exporters
  • Selling Leads of Phytase
  • Suppliers of Phytase
  • Exporters of Phytase
  • Phytase Buyers List 

 Safety and Guides

  • Tri-State Swine Nutrition Guide
  • Industry Guidelines for the Use of Enzymes in  Dietary Supplements
  • List of Safety and Guidelines of Phytase

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