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Contents on the CD Rom

  • BOTOX® is a drug known most widely for its ability to temporarily smooth out facial wrinkles, though it also has several medical applications. Both its cosmetic and medical applications relate to Botox’s ability to block muscle contractions.
  • Botox belongs to a class of products known as biologics—physiologically active substances produced naturally by organisms (in this case bacteria) or synthetically in the laboratory
  • Botulinum toxin is a neurotoxin protein produced by the bacterium Clostridium botulinum. It is one of the most poisonous naturally occurring substances in the world, and it is the most toxic protein. It is sold commercially under the brand names Botox and Dysport for this purpose. The terms Botox and Dysport are trade names and are not used generically to describe the neurotoxins produced by the clostridia species.
  • Botox blocks signals from the nerves to the muscles. The injected muscle can no longer contract, which causes the wrinkles to relax and soften. It is most often used on forehead lines, crow's feet (lines around the eye) and frown lines. Wrinkles caused by sun damage and gravity will not respond to Botox.
  • The market trend for BOTOX® injection rates are up 31%, while alternatives such as chemical peels are down 31%, and collagen injections, once very popular, have dropped by 46%. The consumer can pay $5000 for a facelift to remove lines and wrinkles now, or as an alternative can undertake twelve BOTOX® injections over time.
  • Consumers are avid for non-invasive alternatives to Botox and cosmetic surgery, driving a "cosmeceuticals" market destined to grow 8.5% to $5.1 billion by 2007.
  • The increase in popularity of nonsurgical procedures like Botox injections for wrinkles is due to people becoming satisfied with less drastic measures to remove wrinkles. From 2002 to 2003, the demand for Botox injections for wrinkles resulted in a 153 percent increase, accounting for more than 887,000 procedures. 
  • Costs for botox can vary significantly based on how much an individual needs and wishes to get, and based on who is administering it. Some skin care centers advertise low prices for botox on a "cost per area" basis, advertising prices of $200-$300 for one area.
  • The first rule of Botox safety is that the procedure is perform only by a board certified plastic surgeon who has experience with all aspects of the Procedure. 
  • Botox is approved by the U.S. Food and Drug Administration (FDA) to treat several medical conditions (its “therapeutic” applications):
    • Cervical Dystonia – involuntary movement and prolonged muscle contraction of the neck, • Blepharospasm – involuntary forcible closure of the eyelids, • Strabismus – crossed eyes, • Hyperhidrosis – excessive sweating, • Dynamic muscle contracture in pediatric cerebral palsy patients (approved as an orphan drug) – an abnormality of motor function usually acquired at a young age.
  • Botox has been approved for cosmetic applications in the following countries: Canada (2001), New Zealand (2001), United States (2002), Australia (2002), Switzerland (2002), Taiwan (2002), Singapore (2002), and France. 
  • Botulinum toxin type A, brand name Botox®, is an effective preventative therapy for headache and Migraine pain in chronic sufferers, according to the largest study performed to date, presented at the 45th Annual Scientific Meeting of the American Headache Society (AHS) in June.
  • Botox is approved by the Food and Drug Administration (FDA) for treatment of blepharospasm (eyelid spasm), strabismus (crossed eyes), cervical dystonia (painful neck spasms) and wrinkles between the eyebrows, but not for headache or Migraine. Studies to obtain FDA approval for that use are proceeding
 General Information
  • Botulinum toxin
  • Mini botox
  • Botox alternatives
  • Botulinum Toxin
  • Botulinum Toxin Primer
  • Botulinum Toxin: Its Nature            and role in CP
  • The Quick Fix: Botox
  • Toronto Botox
  • BOTOX® Fact Sheet

Production Process

  • Manufacturing Process of Botox
  • Growth of and Toxin Production by Nonproteolytic Clostridium botulinum in Cooked Pure´ed Vegetables at Refrigeration Temperatures 
  • Effects on Growth and Toxin Production of Exposure of Spores of Clostridium botulinum Type F to Sublethal Doses of Gamma Irradiation 
  • Clostridium botulinum toxin development in refrigerated reduced oxygen packaged Atlantic croaker 
  • Physiology of Toxin Production by Clostridium Botulinum                 Types A and B 
  • The Effects of Modified Atmosphere Packaging on Toxin Production by Clostridium botulinum in Raw Aquacultured Flounder Fillets and Fully Cooked Breaded and Battered Pollock Portions 
  • Refinement and Reduction in Botulinum Toxin Testing

Functions and Properties

  • Effects of Botulinum Toxin Type D on Secretion of Tumor Necrosis Factor from Human Monocytes 
  • Functional Evaluation and Treatment of Muscle Overactivity 

  • Botulinum Toxin Type B Pharmacology and Biochemistry

  • Properties and Use of Botulinum Toxin and Other Microbial Neurotoxins in Medicine 

Company Profiles

  • Nova Medical Skin Care
  • Accolade Pharmaceuticals Pte Ltd
  • Allergan, Inc
  • EpiTan Ltd.
  • Obagi Medical Products Inc


  • Gerry E.Conti
  • Fauquier ENT Consultants
  • List of Consultants
  • London Pain Consultants
  • K-T Solutions
  • South Shore Medical Beauty Consultants


  • Bioprocess for the production of recombinant anti-botulinum toxin antibody
  • Botulinum toxin production method
  • Leucine-based motif and clostridial neurotoxins
  • Cosmetic use of botulinum toxin for treatment of downturned mouth
  • Method for treating hyperhidrosis in mammals
  • Lipotox

Products and  Material Safety Data Sheet

  • Botox Purified Neurotoxin Complex
  • Botox Injections
  • Myobloc
  • Botulinum Toxin Type A
  • Botox Products List
  • Anti Wrinkle 55
  • Botox Cosmetic
  • Botox Skin Care Products
  • BIOX Intensive Anti-Aging Serum 
  • Data Sheet for Purified Neurotoxin Complex


  • Botox® injections combined with surgery for migraine treatment
  • New Uses Emerge for Light-Emitting Diode Technology
  • Botulinum toxin type B micromechanosensor
  • The Technology of Beauty


  • Application of botulinum toxin to reduce the saliva in patients with amyotrophic lateral sclerosis 
  • Low-Dose Efficacy of Botulinum Toxin A for Axillary Hyperhidrosis
  • Botulinum Toxin Type A For Treatment of Cervical Dystonia 
  • Botulinum Toxin for Myofascial Pain
  • Botulinum Toxin as a Biological Weapon
  • Contraindications and Complications With the Use of Botulinum Toxin 

  • Growing Old Disgracefully: The Cosmetic Use of Botulinum Toxin
  • Application of Botox® for Pedal Hyperhydrosis
  • Botox : Correct Wrinkles


  • BOTOX® Alternatives
  • Exploring the Botox Fad
  • Botox In A Bottle: Driving Cosmeceutical Growth
  • Botox Injections for Wrinkles
  • Botox: How food poisoning was tamed to make people look young
  • Hotly contested market for wrinkle removers


  • Allergen Annual Report 2006
  • The Latest Buzz: About Botox
  • Botox: Medical Officer's Review
  • Summary of the NIAID Expert Panel on Botulinum Toxins
  • Allergen's Botox not the cause of Botulism in Florida Patients
  • Botox
  • Botox Down Under
  • Botox for Head Pain, Largest Study Yet
  • Is Any Cosmetic Better Than Botox?


  • Allergan Botox Ireland
  • The effect of multi-level botulinum toxin
  • Evaluate the potential of a quail embryo bioassay to replace the mouse bioassay for the assessment of Botulinum toxin activity
  • Regulation of Botulinum Neurotoxin Expression
  • Botox for the brain
  • The Compliance of the use of Botulinum Toxins in BHR Trust against Local and National Standard

Suppliers and Buyers

  • Broadway Botox
  • Botox Selling Leads
  • Jingmen Ever-Young Biotechnology Co., Ltd
  • Botox Suppliers
  • Westgate Distributors
  • Botox Buyers List

Hazards and  Risks

  • Inhalational Poisoning by Botulinum Toxin and Inhalation Vaccination with Its Heavy-Chain Component
  • Botulism Poisoning 
  • Botox risks

Safety Issues

  • Botox Safety
  • Safety and Efficacy of Botox® Cosmetic
  • Botox Cosmetic Safety
  • Efficacy and Safety of Botox
  • Botox Safety Procedures


  • Frequently Asked Questions about Botox
  • A Consumer's Guide to Botox
  • FAQ on Botox Treatment
  • Botox Treatment Cost
  • Guidelines for the use of botulinum toxin (BTX) in the management of spasticity in adults
  • Botulinum Toxin Injections Clinical Guideline
  • Botulism Exposure Guidelines
  • Information on Botox Injections

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