- Calcitonin is a 32
amino acid polypeptide hormone that is produced in humans primarily by
the Parafollicular (also known as C) cells of the thyroid, and in many
other animals in the ultimobranchial body. It acts to reduce blood
calcium Ca2+, opposing the effects of parathyroid hormone (PTH). It has
been found in fish, reptiles, birds and mammals. Its importance in
humans has not been as well established as its importance in other
animals.
- Calcitonin is formed by
the proteolytic cleavage of a larger prepropeptide which is the product
of the CALC1 gene (CALCA). The CALC1 gene belongs to a superfamily of
related protein hormone precursors including islet amyloid precursor
protein, calcitonin gene-related peptide, and the precursor of
adrenomedullin. The hormone participates in calcium (Ca2+) and
phosphorus metabolism. In many ways, calcitonin has the counter effects
of parathyroid hormone (PTH).
- Oral calcitonin may
have a chondroprotective role in osteoarthritis (OA), according to data
in rats presented last month at the 10th World Congress of the
Osteoarthritis Research Society International (OARSI) in Boston,
Massachusetts. Unlike several other potential disease-modifying OA
drugs, calcitonin also has a “unique analgesic effect on bone pain,
which might relieve at least in part symptoms accompanying joint
disease,” says Dr. Karsdal, adding that this may be an important factor
influencing future drug compliance.
- This medication is used
to treat certain bone problems (e.g., Paget's disease, postmenopausal
osteoporosis) and to reduce high blood levels of calcium. Calcitonin is
a man-made hormone that works by slowing bone loss and maintaining
normal calcium levels in the blood. It may also help to reduce bone pain
in people who have Paget's disease.
- A joint venture between
US-based Unigene Laboratories and China's Shijiazhuang Pharmaceutical
Group will begin selling injectable calcitonin in China for the
treatment of osteoporosis as of 1 April. China is the single largest
osteoporosis market with an estimated 90 million sufferers and more than
15 million fractures per year, the company claimed. According to the
Shanghai Medical Journal and Chinese medical experts, 90 per cent of
Chinese citizens over 60, and virtually all of those over 70, have the
disease. The Chinese government has identified osteoporosis as one of
the top three health priorities in China.
- Unigene's net loss for
the three months ended March 31, 2007 was $244,000, or $.00 per share,
compared to a net loss of $3,243,000, or $.04 per share for the three
months ended March 31, 2006.The three months ended March 31, 2007 and
2006 includes $393,000 and $165,000, respectively, in expenses for
non-cash stock optio compensation. As of March 31, 2007, Unigene had
approximately $697,000 in expenses for non-cash stock option
compensation that remains to be recognized, primarily over the next 12
months.
- US pharmaceutical
company Upsher-Smith Laboratories has been forced into staffing cuts and
a restructuring exercise by delays in the US Food and Drug
Administration's review of its nasal calcitonin product for
osteoporosis. Upsher-Smith licensed the product, called Fortical, from
nasal drug delivery specialist Unigene in 2002. This $10 million (€8.3m)
agreement gave Upsher-Smith exclusive US rights to distribute and sell
the finished product, with Unigene retaining manufacturing
rights.
- An oral formulation of
salmon calcitonin based on Emisphere Technologies' eligen delivery
system has entered Phase III clinical trials for the treatment of
osteoarthritis. According to Emisphere, the system has been used for
oral delivery of a range of molecules varying in size from 500 Daltons
to more than 150,000 Daltons. Oral formulations created with the eligen
technology include tablets, solutions and capsules; Emisphere believes
it is also applicable to controlled-release dosage forms.
- Miacalcic is registered
in 97 countries around the world and it is estimated that it has been
administered for over 3 million patient years since it was first
launched in 1974 in an injectable form. Miacalcic Nasal Spray received
its first approval in 1987. Its first European Union marketing licence
for post-menopausal osteoporosis was obtained in Portugal in 1987,
followed by subsequent approvals in other countries.
- The osteoporosis
pharmaceutical market is currently $7 billion and is expected to grow to
$14 billion by 2011. According to IMS, a market research firm, worldwide
sales of an existing Calcitonin-Salmon Nasal Spray were approximately
$389 million in 2003, of which the U.S. accounts for an estimated $240
million.
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General Information
- Calcitonin
- Calcitonin: Discovery
and Early Development
- Calcitonin - Concentrated and Prediluted Polyclonal Antibody
- Calcitonin
Information
Extraction and
Purification
- Oral Delivery and
Recombinant Production of Peptide Hormones
- A Non-calcitonin
Secretory Peptide Derived from Preprocalcitonin
- New Calcitonin Isolated
from the Ray
- Immunoreactive
Calcitonin Production by a Human Promyelocytic Leukemia Cell Line
HL60
-
Purification
of Calcitonin-Like Peptides from Rat Brain and Pituitary
Functions
- The Actions of
Calcitonin on the TM3 Leydig Cell Line and on Rat Leydig Cell-Enriched
Cultures
- Vascular and Renal
Actions of Salmon Calcitonin in Freshwater and Seawater Adapted European
Eels
- Calcitonin Bone
Formation: a Knockout Full of Surprise
- Characterization of rat
calcitonin mRNA
- Calcitonin, an
enigmatic hormone
-
Isolation,
Structure, Synthesis, and Activity of a New Member of the Calcitonin
Gene-related Peptide Family from Frog Skin and Molecular Cloning of Its
Precursor
-
Calcitonin
Gene-Related Peptide Rapidly Downregulates Nicotinic Receptor Function
and Slowly Raises Intracellular Ca21 in Rat Chromaffin Cells In
Vitro
-
Salmon
Calcitonin-Induced Stimulation
-
Calcium
intake by rats: influence of parathyroid hormone, calcitonin, and
1,25-dihydroxyvitamin D
-
Characterization of the Human Calcitonin Gene-Related
Peptide Receptor Subtypes Associated with Receptor Activity-Modifying
Proteins
Company
Profiles
- AnaSpec
- Bachem
- Bam Biotech Co
Ltd
- Nastech Pharmaceutical
Company
- Unigene
- Upsher-Smith
Laboratories, Inc
Consultants
- Andrew Lawrence
Frelinger III, Ph.D.
- David C. Yeomans,
PhD
- Intota
- Graham Young
- John P. Lenihan,
MD
- Peter Petrusz
- William Y.W.AU,
M.D
Patent
- Procedure for preparing
salmon calcitonin
- S-sulfonated calcitonin
derivatives
- Mixtures of calcitonin
drug-oligomer conjugates comprising polyalkylene glycol, uses thereof,
and methods of making same
- Use of calcitonin in
osteoarthritis
- Stabilized calcitonin
pharmaceutical composition
- Human calcitonin
receptor polypeptides
- Use of calcitonin and
calcitonin-like peptides to treat and prevent multiple sclerosis
- Intranasal calcitonin
formulations
- Calcitonin analogue and
use thereof
- Synthetic calcitonin
peptides
Technology
-
Expression
and Localization of Prohormone Convertase PC1 in the
Calcitonin-producing Cells of the Bullfrog Ultimobranchial
Gland
-
Calcitonin Is
a Progesterone Regulated Marker That Forecasts the Receptive State of
Endometrium during Implantation
-
Purification
of a functional competitive antagonist for calcitonin gene related
peptide action from sardine hydrolysates
- Calcitonin Gene-Related
Peptide Immunoreactivity in the Spinal Cord of Man and Eight Other
Species
-
Recent
Developments in Intranasal Drug Delivery Technology are Creating
New Vistas for Peptide and Protein Therapeutics
-
Enhanced
Bioavailability of Calcitonin Formulated with Alkylglycosides following
Nasal and Ocular Administration in Rats
Material Safety Data
Sheet
- Thyroid ELISA
Kits
- Calcitonin Gene-Related
Peptide CGRP Receptor
- Mouse Monoclonal
Antibody
- Rabbit Anti-Calcitonin
Gene Related Peptide Polyclonal Antibody
- Double Antibody
Calcitonin
- Calcitonin In-vitro
Diagnostic Test Kit
- Immulite Calcitonin
Control Module
- Peptide-affinity
Purified Polyclonal Antibody to Calcitonin Receptor
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Applications
-
The role of
calcitonin for fracture pain
- Calcitonin Inj
Uses
-
Meta-Analysis
of Calcitonin for the Treatment of Postmenopausal
Osteoporosis
-
A Randomized
Trial of Nasal Spray Salmon Calcitonin in Postmenopausal Women with
Established Osteoporosis
- Use of Calcitonin To
Treat Phantom Limb Pain
-
Osteoporosis
management in day-to-day practice. The role of calcitonin
- Nanomedicines for
Overcoming Biological Barriers: Nanoparticles as Carriers for Intestinal
Drug Absorption
-
Calcitonin
gene-related peptide-induced suppression of luteinizing hormone pulses
in the rat
Products
- Calcitonin Related
Peptides
- Injectable Salmon
Calcitonin
- Calcitonin
Receptor
- Calcitonin related
polypeptide, beta
- Calcitonin Products
List
- Calcitonin &
Calcitonin Receptors/Related Products
Market
- Market Penetration
Ananlysis
- The Women's Health
Resource Center
- Unigene JV launches
calcitonin in China
- Efficacy of calcitonin
in treatment of post-menopausal osteoporosis confirmed by European
regulatory authority
- FDA accepts ANDA filing
for Calcitonin-Salmon Nasal Spray
- Nasal calcitonin delay hits Upsher-Smith
Labs
-
Formulary
Reclassification Calcitonin Nasal Spray
- Novartis receives
European marketing authorization for Aclasta
- Oral calcitonin into Phase III for
osteoarthritis
- Awakening the Silent
Osteoporosis Market
- Unigene Announces
Strong Increase in Revenue and Improved Quarterly Income for First
Quarter 2007
Report
- Calcitonin
Enzyme-Linked ImmunoSorbent Assay
- Calcitonin is expressed
in the chicken pituitary gland
- Role of Calcitonin
Gene-Related Peptide in the Postischemic Anti-inflammatory Effects of
Antecedent Ethanol Ingestion
-
Calcitonin:
characterisation and expression in a teleost fish, Fugu
rubripes
- Calcitonin Test
-
Effects of
pertussis toxin on adenylate cyclase responses to prostaglandin E2 and
calcitonin in human breast cancer cells
- Immunoreactive
Substance P and Calcitonin gene Related Peptide in Rat Milk and in Human
Milk and Infant Formulas
-
Peptidome
project: Analysis of peptides in pig and mouse brain for the Peptidome
database
Suppliers
- Chinese Suppliers
for Calcitonin salmon
- China Suppliers of
Calcitonin
- Indian Suppliers of
Calcitonin
- Selling Leads of
Calcitonin
- Foreign
Exporters & Manufacturers
- Calcitonin
Suppliers
- Calcitonin (Salmon)
Manufacturers
- Exporters of
Calcitonin
- Sellers of
Calcitonin
- Calcitonin
Manufacturers
Buyers
- Foreign
Importers & Buyers of Calcitonin
- Buying Leads of
Calcitonin
- Calcitonin Buyers
List
Equipments
Suppliers
- Diagnostic Systems
Laboratories
- Calcitonin RIA
kit
- Calcitonin Control
Slide Suppliers
- Modern Laboratory
Services
- Calcitonin ris Kit
Suppliers Directory
Safety and
Guides
- Therapeutic or
Pharmacological Classification
-
Calcitonin-Salmon (rDNA origin) Nasal Spray For Intranasal
- Miacalcin - Calcitonin
- Dosage - Side Effects - Drug Interactions
- Frequently asked
Questions about Calcitonin Salmon Injection
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