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  • Furosemide (INN) or frusemide (former BAN) is a loop diuretic.
    It is most commonly marketed by Sanofi-Aventis under the brand name Lasix.
  • The name of lasix is derived from lasts six (hours) -- referring to its duration of action.
  • Furosemide is a noncompetitive subtype-specific blocker of GABA-A receptors.
  • Furosemide is odorless white to slightly yellow crystalline powder.
  • Furosemide is a diuretic which is an anthranilic acid derivative.
    It is practically insoluble in water, sparingly soluble in alcohol, freely soluble in dilute alkali solutions and insoluble in dilute acids.
  • Furosemide may undergo hydrolysis at sufficiently low pH.
    The spherical agglomeration process is used to delay the dissolution of furosemide.
  • Hyperprostaglandin E syndrome/antenatal Bartter syndrome (HPS/aBS), a salt-losing tubulopathy of the furosemide type , is clinically characterized by polyhydramnios leading to premature delivery, hypoisosthenuria with marked polyuria, and severe hypercalciuria resulting
    in nephrocalcinosis.
  • Pre-systemic metabolism of frusemide is carried out by the intestine while systemic clearance of frusemide is mainly performed by the kidneys with contributions from the intestine and the liver.
  • The improving of the solubility and UV stability of furosemide, a poorly water soluble diuretic can be done by complexation with ▀-cyclodextrin.
  • A sensitive, selective and efficient micellar liquid chromatographic (MLC) procedure was developed for the determination of furosemide (4-chloro-N-furfuryl-5-sulfamoylanthranilic acid) in urine samples by direct injection and UV detection.
  • Furosemide improves medullary oxygenation by reducing oxygen consumption rather than by increasing regional blood flow.
  • Frusemide is commonly used in conditions such as heart failure, where the pumping mechanism of the heart is less effective.
  • Frusemide is frequently used to facilitate fluid and electrolyte management of acute renal failure in many institutions.
    Furosemide increases water content in renal tissue.
  • Urinary-system elimination of 18F-FDG can be mistaken for pathologic uptake. Furosemide helps eliminate this artifact.
  • Chronic subcutane-ous infusion of furosemide, with concomitant salt and water substitution, was used to examine the isolated effect of prolonged inhibition of NaCl transport in the cTALH/macula densa cells on expression of COX-2 in rat kidney cortex.
  • Frusemide has significant bronchodilatory effect when given through inhaled route but less effective than salbutamol.
  • NIR spectroscopy technique was used to evaluate 48 different formulations of furosemide tablets.
  • The short-term effects of intravenous administration of furosemide on key functions in the kidney cortex has been evaluated using magnetic resonance imaging (MRI) technique.
General Information
  • Chemical data sheet for Furosemide
  • Furosemide Injection
  • Furosemide
  • About Furosemide (Frusemide)

Company Profiles

  • Company from California
  • Company from China
  • Company from Germany
  • Company from India
  • Indian Company from Mumbai
  • Company from Jordan
  • Company from Syria
  • Company from USA
  • Company from Vadadora

Process

  • Controlled release of Furosemide from Spherical Agglomerates prepared by an oil agglomeration process
  • Biotransformation of Furosemide in Kidney Transplant Patients
  • Further errors in polymorph identification: furosemide and finasteride
  • Evaluation of furosemide regimens in neonates treated with extracorporeal membrane oxygenation
  • Meta-analysis of frusemide to prevent or treat acute renal failure
  • Dominant Role of Prostaglandin E2 EP4 Receptor in Furosemide-Induced Salt-Losing Tubulopathy: A Model for Hyperprostaglandin E Syndrome / Antenatal Bartter Syndrome
  • Pharmacokinetic study of frusemide in healthy and cirrhotic indian subjects
  • Synthesis and Characterization of Furosemide complexes in β-cyclodextrin
  • Determination of furosemide in urine samples by direct injection in a micellar liquid chromatographic system

Application

  • Using Furosemide as a Pre-contest Diuretic
  • Continuous-Dose Furosemide Attenuates TNF Levels in Acute Respiratory Distress Syndrome (ARDS)
  • An evaluation of the interaction of meloxicam with frusemide in patients with compensated chronic cardiac failure
  • A Furosemide - Sensitive Cotransport of Sodium plus Potassium in the Human Red Cell
  • Furosemide increases water content in renal tissue
  • Intravenous Furosemide Injection During 18F-FDG PET Acquisition
  • Furosemide-Sensitive Cl Transport in Bovine Retinal Pigment Epithelium
  • Rapid Oral Desensitization to Furosemide in a Patient with Sulfonamide Allergy
  • Furosemide stimulates macula densa cyclooxygenase-2 expression in rats
  • The Role of Inhaled Frusemide in Management of Bronchial Asthma

Material Safety Data Sheet

  • Safety data for furosemide
  • Furosemide
  • Disal (Furosemide) Injection Nada
  • Lasix Tablets
  • Disal (Furosemide) Tablets
  • Furosemide Injection, USP

Patent

  • Furosemide Modulators of HM74
  • Process for the preparation of Furosemide
  • Furosemide Salts
  • Furosemide as tinnitus suppressant
  • Urapidil/Furosemide compounds compositions and uses
Technology
  • Changes in Intra-Renal oxygenation post furosemide as evaluated by BOLD MRI : Effect of age and Inhibition of prostaglandin synthesis
  • Influence of hypertonic-hyperoncotic solution and furosemide on canine hydrostatic pulmonary oedema resorption
  • Furosemide-Loaded Microspheres were prepared by the ionic cross linking technique : Morphology and Release Characteristics
  • Novel Spectrophotometric estimation of Frusemide using hydrotropic Solubilization phenomenon
  • Process Analytical Technology (PAT) Tools: Chemometric Evaluation of Furosemide Tablet Formulations
  • Furosemide-augmented Intravenous Urography: Results in Essential Hypertension

Consultant & Project
  • Consultant from USA
  • Consultant from New Jersey
  • Frusemide Infusion for the Prevention of Deterioration in Renal Function Post Cardiac Surgery
  • Mechanism of Transport Regulation in the Kidney
  • The Carcinogenic Potency Project - Furosemide

Product

  • Frusemide BC
  • Frusem 40
  • FUSID«
  • LASIX«
  • Furosemide Oral Solution

Function

  • Effect of Intravenous Administration of Frusemide on the Blood Sugar and Alloxan Diabetic Rabbits
  • Dilatory Effect of Furosemide on Rat Tracheal Arterioles and Venules
  • Effects of acute hypovolaemia by furosemide on tracheal transepithelial potential difference and mucus in dogs
  • Inhaled frusemide does not affect lung mucociliary clearance in healthy and asthmatic subjects
  • Effects of Furosemide on Distortion Product Otoacoustic Emissions and on Neuronal Responses in the Anteroventral Cochlear Nucleus
  • The effect of Frusemide on Indomethacin Plasma Levels

Report

  • Furosemide in the Long-Term Management of Heart Failure
  • Furosemide responsiveness, non-adherence and resistance during the chronic treatment of heart failure: a longitudinal study
  • Report of Case: Partial Ureteral Obstruction Masked by Diuretics During Intraoperative Cystoscopy
  • Furosemide-induced bullous pemphigoid: case report and review of literature
  • Effects of cyclic AMP, ouabain and furosemide on ion transport in isolated canine gastric mucosa
  • Differential effect of frusemide on renal medullary and cortical blood flow in the anaesthetised rat

Suppliers

  • Suppliers of Furosemide
  • Selling leads of Furosemide
  • Exporters of Furosemide

 

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