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Project at a Glance Contents on the CD ROM
  • The isosorbide is a heterocyclic compound obtained from reaction of the double dehydration of sorbitol , which is itself derived from the reaction of hydrogenation of glucose.
  • Isosorbide is a diol derived from agricultural resources, non toxic, biodegradable and thermally stable.
  • The isosorbide is a monomer that can be inserted into the macromolecular chains of type polymers
  •  It is also used for the synthesis of derivatives such as diesters, diethers, dinitrates.
  • The isosorbide is a white solid soluble in water, alcohols and ketones and almost insoluble in hydrocarbons , the ethers and  esters.
  • The isosorbide is very hygroscopic , that is to say, it tends to absorb moisture from environmental absorption or adsorption.
  • The isosorbide is non-toxic and heat stable. This molecule does not break down that from 270 C in the absence of oxygen.
  • Isosorbide is a used as a diuretic used mainly to treat hydrocephalus and is also used to treat glaucoma.
  • Other medications are derived from isosorbide, including isosorbide dinitrate and isosorbide mononitrate, are used to treat angina pectoris. Other isosorbide-based medicines are used as osmotic diuretics and for treatment of esophageal varices.
  • Isosorbide is used to prevent or treat chest pain (angina). It works by relaxing the blood vessels to the heart, so the blood and oxygen supply to the heart is increased.
  • Isosorbide is a polmer component or additive that can significantly improve the performance characteristics of plastics.
  • The advantage of isosorbide is that it can raise the use temperature and performance for moldable plastics.
  • Isosorbide has been demonstrated to be a very
    effective monomer for raising the glass transition
    temperature of polymers. The major applications are as a copolymer with PET for the use in bottle production.
  • The use of biobased isosorbide as a polymer additive has the potential to reduce the amount of petroleum feedstocks used in the polymer industry, lower emissions (e.g., carbon dioxide), and offer a higher value-added alternative for corn growers and other agribusinesses.
  • Isosorbide can be substituted for other diols in order to create new polyesters,
    polycarbonates etc,.
General Information
  • Isosorbide General Info
  • Isosorbide Information
  • Isosorbide Dinitrate
  • Isosorbide Mononitrate
  • Isosorbide Information
  • Isosorbide facts
  • Isosorbide Mononitrate

Company

  • Company from USA
  • Company from China
  • Company from India
  • Company from China
  • Company from UK
  • Company from China
  • Company from USA

Plant

  • Plant from India
  • Plant from USA
  • Plant from India

Consultancy

  • Consultancy from USA
  • Consultancy from India
  • Consultancy from China

Data Sheet

  • Isosorbide
  • Isosorbide, 98%
  • Isordil
  • D-Isosorbide
  • Isosorbide Dinitrate
  • Isosorbide Mononitrate
  • Isosorbide Dinitrate Sublingual Tablets
  • Isosorbide Dinitrate Hard Gelatin Capsules
  • D-Isosorbide
  • Polysorb Isosorbide

Product

  • Isosorbide Dinitrate 10mg and 20mg Tablets
  • BiDil
  • Isordil
  • Isosorbide-5-mononitrate
  • Isosorbide-5-nitrate 20 mg tablet
  • Isosorbide Dinitrate
  • Isosorbide mononitrate

Process

  • Catalysts for Isosorbide - production
  • Continuous Isosorbide Production from Sorbitol using Solid Acid Catalysis

Toxicity

  • Determination of Isosorbide Dinitrate and Metabolites in Human Plasma Using Negative Ion ESI-LC/MS/MS
  • Nephrotoxicity of Isosorbide Dinitrate and Cholestasis in Rat: The Possible Role of Nitric Oxide
  • Plasma concentrations of Isosorbide Dinitrate and its metabolites after chronic high oral dosage in man

Report & Market

  • Fueling the Economy
  • FDA approval for generic Isosorbide Dinitrate
  • Isosorbide general Opinion
  • Biochemical and Products Peer Review
  • New Industrial production of Isosorbide
  • Addition of Biobased Isosorbide to polyethylene terephthalate increases strength and rigidity of polyethylate tetephthalate
  • Catalytic application in the production of next generation biofuels and bio-based chemicals
  • Isosorbide as sustainable diol from the C6 platform

Application

  • Isosorbide: A Sustainable and
    Non-Toxic Diol for Polymers
  • Isosorbide as a New Green Building Block for Polymers & Plasticizers
  • In vivo three-dimensional EPR imaging of nitric oxide production from isosorbide dinitrate in mice
  • Isosorbide, a green diol for polymers
  • Isosorbide as a novel polar head derived from renewable resources.
    Application to the design of short-chain amphiphiles with hydrotropic properties

Functions

  • Effectiveness of isosorbide dinitrate and nitroglycerin in relieving angina pectoris
  • Isosorbide in treatment of infantile hydrocephalus
  • Dilatation of coronary artery stenoses after isosorbide dinitrate in man
  • Effect of a combined treatment with propranolol and Isosorbide-5- Mononitrate on Doppler Ultra sound Parameters in Patients with cirrhosis and portal Hypertension
  • Effectiveness of Isosorbide Dinitrate and hydralazine in Racial /Ethnic subgroups with Heart Failure
  • Inhibition of angiogenesis, tumour growth and metastasis by the
    NO-releasing vasodilators, isosorbide mononitrate & dinitrate
  • Isosorbide-5-mononitrate in the treatment of pulmonary hypertension
  • Potentiation of Radiation-Induced regrowth delay by Isosorbide dinitrate in Fsaii Murine tumors

Patent

  • Isosorbide derivatives
  • Process to produce polyesters which incorporate isosorbide
  • Use of isosorbide ethers in detergents and cleaners
  • Sheets formed from polyesters including isosorbide
  • Purification of isosorbide
  • Method for making isosorbide containing polyesters

Analysis

  • Isosorbide-based aspirin prodrugs
    II. Hydrolysis kinetics of isosorbide diaspirinate
  • Chemical oxygen demand(COD) reduction of Aqueous Active
    Pharmaceutical Ingredient of Isorobide 5-mononitrate waste water streams by Advanced Oxidation-Fenton process
  • A comparison between the effects of diltiazem and isosorbide dinitrate on digoxin pharmacodynamics and kinetics in the treatment of patients with chronic ischemic heart failure
  • Effect of  Timing and Dose of Isosorbide Dinitrate Administration
  • Isosorbide based chiral poly urethanes: optical and thermal studies

Synthesis

  • Isosorbide Polyesters from Enzymatic Catalysis
  • Isosorbide Esters: Enantiopure alcohols derived from Glucose
  • Synthesis, hydrolysis kinetics and anti-platelet effects of isosorbide
    mononitrate derivatives of aspirin

Suppliers

  • Suppliers for Isosorbide
  • Isosorbide Suppliers
  • Isosorbide Suppliers from India
  • Suppliers for Isosorbide

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