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  • Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor.
  • Lamivudine is administered orally, and it is rapidly absorbed with a bio-availability of over 80%. Some research suggests that lamivudine can cross the blood-brain barrier.
  • Lamivudine is often given in combination with zidovudine, with which it is highly synergistic.
  • Lamivudine treatment has been shown to restore zidovudine sensitivity of previously resistant HIV.
  • Several mutagenicity tests show that lamivudine should not show mutagenic activity in therapeutic doses.
  • Lamivudine is an analogue of cytidine.
  • It can inhibit both types of HIV reverse transcriptase and also the reverse transcriptase of hepatitis B. It needs to be phosphorylated to its triphosphate form before it is active.
  •  3TC-triphosphate also inhibits cellular DNA polymerase.
  • Lamivudine is a nucleoside analogue, which was originally licensed for the treatment of HIV.
  • It is now additionally licensed for the treatment of chronic hepatitis B with evidence of viral replication.
  • It is marketed by Glaxo SmithKline with the brand names Zeffix, Heptovir, Epivir, and Epivir-HBV.
  • Transient elastography has demonstrated clinical potential in the noninvasive evaluation of hepatic fibrosis by measurement of liver stiffness in chronic hepatitis C.
  • To determine the mutation of YMDD motif  and codon 528 in chronic HBV patients with lamivudine therapy using PCR-direct sequencing and to investigate the relationship between lamivudine mediated HBV mutation and HBeAg.
  • Urine samples were also obtained from two animals.
  •  The same dose of the racemate  was administered to one animal.
  • The drug was quantitated in CSF and plasma with a reverse-phase high-pressure liquid chromatography technique.
  • Lamivudine has been used for treatment of chronic hepatitis B at a lower dose than for treatment of HIV.
  •  lamivudine is still used widely as it is well tolerated.
  • Lamivudine
  • Lamivudine Information


  • Characterization of Lamivudine Renal Transport
  • Determination of lamivudine by HPLC-UV in pregnant rats
  • Lamivudine plasma levels in chronic hepatitis B patients
  • Preparation and characterization of lamivudine microcapsules using various cellulose polymers
  • Serum hyaluronic acid during lamivudine treatment in chronic hepatitis B

Market & Report

  • New Medicine On the Market
  • Dissolution Profiles of Three Brands of Lamivudine and Zidovudine Combinations in the Nigerian Market
  • Lamivudine in combination with zidovudine, stavudine, or didanosine in patients with HIV-1 infection. A randomized, double-blind, placebo-controlled trial
  • Double-blind placebo-controlled randomised trial of lamivudine in the treatment of acute hepatitis B
  • Report on New Patented Drugs
  • The Reality of Hiv Aids
  • Medicine Procurement of ARVs and Other Essential Medicines in the U.S. Global AIDS Program
  • Basic pharmacology of anti retroviral therapy


  • Efficacy of lamivudine for preventing hepatocellular carcinoma in chronic hepatitis B
  • Effect of Lamivudine on Human T-Cell Leukemia Virus
  • The efficacy & Adverse effects of Gpo-vir in treatment -Naive adult HIV Patents
  • Increased DNA Polymerase Fidelity of the Lamivudine Resistant Variants of Human Hepatitis B Virus DNA Polymerase
  • Lamivudine For Hepatitis B In Liver Transplantation
  • Viral blips during long-term treatment with standard or double dose lamivudine in HBe antigen negative chronic hepatitis B


  • New & Emerging Technology
  • The Changing Landscape in Hepatitis B
  • Detection of Lamivudine-Resistant Mutations of HBV DNA Polymerase Gene Using PCR-Direct Sequencing
  • Pharmacokinetics of Lamivudine and BCH-189 in Plasma and Cerebrospinal Fluid of Nonhuman Primates
  • Quantification of the newly detected lamivudine resistant YSDD variants of Hepatitis B virus using molecular beacons
  • Single Technology Appraisal


  • Consultant from Chicago
  • Consultant from Malaysia
  • Consultant from Nairobi
  • Consultant from US
  • Consultant from Singapore
  • Consultant from USA


  • Suppliers of Lamivudine
  • Lamivudine suppliers
  • Manufacturers of Lamivudine
  • Lamivudine Exporters
  • Distributors of Lamivudine

Company Profiles

  • Company From India
  • Company From New Jersey
  • Company From USA
  • Company From US


  • Safety Data sheet
  • Epzicom
  • Lamivudine
  • Combivir
  • Lamivudine
  • Epivir


  • Anti HIV Triple combination comprising Zidovudine, Lamivudine & Loviride
  • Pharmaceutical Compositions containing  Lamivudine
  • Method for Typing & Detecting HBV
  • Lamivudine containing Pharmaceutical Formulations


  • Lamivudine (Epivir)
  • Lamivudine tablets
  • Zidovudine, Lamivudine & Abacavir Tablets

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