- Lysergol, is an
alkaloid of the ergoline family that occurs in various species of vines
of the Convolvulaceae and some species of fungi. As the minor alkaloid
in the hallucinogenic seeds of Rivea corymbosa (ololiuhqui), Argyreia
nervosa (Hawaiian baby woodrose) and Ipomoea violacea.
- Lysergol is
uncontrolled in the USA, but possession and sale may be illegal under
the Federal Analog Act because of its relationship to LSD and ergine,
which are controlled substances.
- A series of simple
O-acylated derivatives of the naturally occurring clavine alkaloids
lysergol and dihydrolysergol-I were synthesized and tested in-vitro for
their ability to interact with 5-HT2A receptors in rat tail artery,
5-HT2C receptors in piglet choroid plexus, 5-HT1B receptors in
guinea-pig iliac artery and alpha1-adrenergic receptors in rat
aorta.
- Lysergol and its
N(1)-unsubstituted derivatives were found to be partial agonists (alpha
of 0.2-0.4) for 5-HT2C receptor-mediated inositol phosphate accumulation
in piglet choroid plexus
- It is concluded that
O-acylated derivatives of the clavine alkaloids lysergol and
dihydrolysergol-I mimic therapeutically relevant ergolines due to the
complexity of their pharmacological profile as partial agonists and
antagonists at 5-HT2A, 5-HT2C and 5-HT1B receptors, and at
alpha1-adrenergic receptors.
- In terms of market
cost, lysergol is much cheaper than ergonovine and lysergic acid
derivatives while ergonovine is the most costly among all the alkaloids
assayed, thereby indicating the economic importance of these
advantageous changes in the spectra of alkaloids with the use of the
SSF(Solid State Fermentation) system.
- In the examination
of relative and potential transport of ergoline and ergopeptine
alkaloids across isolated gastric tissues in vitro, Ergot alkaloids used
were a mixture of lysergol, lysergic acid, ergonovine, ergocryptine, and
ergotamine tartrate. Lysergol, lysergic acid, and ergonovine were
selected because they represent the alcohol, acid, and amide forms of
the ergoline alkaloids, respectively.
- A strategy has been
suggested to prevent the fescue toxicosis by preventing the absorption
of the alkaloids rather than trying to block their etabolic effect once
they are in the circulatory system. Lysergic acid, lysergol, and
ergonovine have exhibited the greatest absorption potential compared to
the ergopeptine alkaloids that have been the main toxins implicated in
fescue toxicosis.
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General
- Lysergol
- Lysergol -
Alkaloid
- Simple O-acylated derivatives of lysergol and
dihydrolysergol-I
- Crystal structure of
1-hydroxymethyl-10
-methoxy-9,10-dihydrolysergol,
C18H24N2O3
Products and
MSDS
- Argyreia
Nervosa
- Lysergol
MSDS
- Lysergol
Process and
Technology
- Detection of
lysergic acid in ruminal fluid, urine, and in endophyte infected tall
fescue using high-performance liquid chromatography
- Indirect
enzyme-linked immunosorbent assay for
the quantitative estimation of
lysergic acid diethylamide in urine
- Solid Substrate
Mediated Changes in Ergot Alkaloid Spectra in Solid State Fermentation
System
- Analysis of Ergot
Alkaloids by HPLC
- Semiquantitative determination of ergot alkaloids in seed,
straw, and digesta samples using a competitive enzyme-linked
immunosorbent assay
- Synthesis
- Potential of solid
state fermentation for production of ergot alkaloids
Patent
- Process for
Preparing Lysergol Derivatives
- 1-t-butyl ergolines
useful in the treatment of cerebral insufficiency and senile
dementia
- Immunoassay reagents
and methods for determination of LSD and LSD metabolites
- Process for the
Preparation of Polyhydroxylated Steroids, Lysergol and Ergolinic
Alkaloid
- Process for
Preparing N-Methyl Derivatives of Lysergol
- 1 Substituted
Lysergol
- Antibiotic
pharmaceutical composition with lysergol as bio-enhancer and method of
treatment
Projects
- Enhancing Soil -
Water - Nutrient Processes in Souther Piedmont Pasture and Crop
Systems
- The Role of Anerobic
Ruminal Microbes in the Degradation of Ergopeptide Alkaloids
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Application
- Chiral
Separations Using Capillary Electrophoresis
- Studies
Towards the Total Synthesis of Condylocarpine and Studies Towards the
Enantioselective Synthesis of (+)-Methyl Lysergate
- Effect of Alkaloids
of Ololiuqui in Man
- The Ergot
Alkaloids
- Glycosides in
Medicine: "The Role of Glycosidic Residue in Biological
Activity"
- Simple and selective
one-pot replacement of the N-methyl group of tertiary amines
- Cycloalkanecarboxylic Esters Derived from Lysergol,
Dihydrolysergol-I, and
Elymoclavine as Partial Agonists and
Antagonists at Rat 5-HT2A Receptors
Company
Profile
- Company in
Kolkata
- Company in
India
- Company in
Mumbai
- Company in Himachal
Pradesh
- Company in
Gujarat
- Company in
Maharashtra
- Another Company in
Mumbai
- Company in Madhya
Pradesh
Suppliers
- Lysergol
Manufacturers
- Suppliers
- Exporters
- Selling
Leads
Reports
- Effects of ergot on
health and performance of ruminants and carry over of the ergot
alkaloids into edible tissue
- Pharmacologic
Management of Acute Attacks of Migraine and Prevention of Migraine
Headache
- Ergot alkaloid
transport across ruminant gastric tissues
- The Magical and
Ritual Use Of Herbs
- The Effects of
Traditional Endophyte, Endophute - Free, and Novel Endophyte Jesup
Tall Fescue Hay Consumption on Digestion and Nitrogen Retention in
Steers
- The Psychedelic
view
- Modulation of
Plant Ethylene Levels by the Bacterial Enzyme ACC
Deaminase
- Vaccination Against
Ergot Alkaloids and the Effect of Endophyte-Infected Fescue Seed-Based
Diets on Rabbits
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