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Project at a Glance

Contents on the CD Rom

  • Lysergol, is an alkaloid of the ergoline family that occurs in various species of vines of the Convolvulaceae and some species of fungi. As the minor alkaloid in the hallucinogenic seeds of Rivea corymbosa (ololiuhqui), Argyreia nervosa (Hawaiian baby woodrose) and Ipomoea violacea.
  • Lysergol is uncontrolled in the USA, but possession and sale may be illegal under the Federal Analog Act because of its relationship to LSD and ergine, which are controlled substances.
  • A series of simple O-acylated derivatives of the naturally occurring clavine alkaloids lysergol and dihydrolysergol-I were synthesized and tested in-vitro for their ability to interact with 5-HT2A receptors in rat tail artery, 5-HT2C receptors in piglet choroid plexus, 5-HT1B receptors in guinea-pig iliac artery and alpha1-adrenergic receptors in rat aorta.
  • Lysergol and its N(1)-unsubstituted derivatives were found to be partial agonists (alpha of 0.2-0.4) for 5-HT2C receptor-mediated inositol phosphate accumulation in piglet choroid plexus
  • It is concluded that O-acylated derivatives of the clavine alkaloids lysergol and dihydrolysergol-I mimic therapeutically relevant ergolines due to the complexity of their pharmacological profile as partial agonists and antagonists at 5-HT2A, 5-HT2C and 5-HT1B receptors, and at alpha1-adrenergic receptors.
  • In terms of market cost, lysergol is much cheaper than ergonovine and lysergic acid derivatives while ergonovine is the most costly among all the alkaloids assayed, thereby indicating the economic importance of these advantageous changes in the spectra of alkaloids with the use of the SSF(Solid State Fermentation) system.
  • In the examination of relative and potential transport of ergoline and ergopeptine alkaloids across isolated gastric tissues in vitro, Ergot alkaloids used were a mixture of lysergol, lysergic acid, ergonovine, ergocryptine, and ergotamine tartrate. Lysergol, lysergic acid, and ergonovine were selected because they represent the alcohol, acid, and amide forms of the ergoline alkaloids, respectively.
  • A strategy has been suggested to prevent the fescue toxicosis by preventing the absorption of the alkaloids rather than trying to block their etabolic effect once they are in the circulatory system. Lysergic acid, lysergol, and ergonovine have exhibited the greatest absorption potential compared to the ergopeptine alkaloids that have been the main toxins implicated in fescue toxicosis.
  • Lysergol
  • Lysergol - Alkaloid
  • Simple O-acylated derivatives of lysergol and dihydrolysergol-I
  • Crystal structure of 1-hydroxymethyl-10 -methoxy-9,10-dihydrolysergol,

Products and MSDS

  • Argyreia Nervosa
  • Lysergol MSDS
  • Lysergol

Process and Technology

  • Detection of lysergic acid in ruminal fluid, urine, and in endophyte infected tall fescue using high-performance liquid chromatography
  • Indirect enzyme-linked immunosorbent assay for
    the quantitative estimation of lysergic acid diethylamide in urine
  • Solid Substrate Mediated Changes in Ergot Alkaloid Spectra in Solid State Fermentation System
  • Analysis of Ergot Alkaloids by HPLC
  • Semiquantitative determination of ergot alkaloids in seed, straw, and digesta samples using a competitive enzyme-linked immunosorbent assay
  • Synthesis
  • Potential of solid state fermentation for production of ergot alkaloids


  • Process for Preparing Lysergol Derivatives
  • 1-t-butyl ergolines useful in the treatment of cerebral insufficiency and senile dementia
  • Immunoassay reagents and methods for determination of LSD and LSD metabolites
  • Process for the Preparation of Polyhydroxylated Steroids, Lysergol and Ergolinic Alkaloid
  • Process for Preparing N-Methyl Derivatives of Lysergol
  • 1 Substituted Lysergol
  • Antibiotic pharmaceutical composition with lysergol as bio-enhancer and method of treatment


  • Enhancing Soil - Water - Nutrient Processes in Souther Piedmont Pasture and Crop Systems
  • The Role of Anerobic Ruminal Microbes in the Degradation of Ergopeptide Alkaloids
  • Chiral Separations Using Capillary Electrophoresis
  • Studies Towards the Total Synthesis of Condylocarpine and Studies Towards the Enantioselective Synthesis of (+)-Methyl Lysergate
  • Effect of Alkaloids of Ololiuqui in Man
  • The Ergot Alkaloids
  • Glycosides in Medicine: "The Role of Glycosidic Residue in Biological Activity"
  • Simple and selective one-pot replacement of the N-methyl group of tertiary amines
  • Cycloalkanecarboxylic Esters Derived from Lysergol, Dihydrolysergol-I, and
    Elymoclavine as Partial Agonists and Antagonists at Rat 5-HT2A Receptors

Company Profile

  • Company in Kolkata
  • Company in India
  • Company in Mumbai
  • Company in Himachal Pradesh
  • Company in Gujarat
  • Company in Maharashtra
  • Another Company in Mumbai
  • Company in Madhya Pradesh


  • Lysergol Manufacturers
  • Suppliers
  • Exporters
  • Selling Leads


  • Effects of ergot on health and performance of ruminants and carry over of the ergot alkaloids into edible tissue
  • Pharmacologic Management of Acute Attacks of Migraine and Prevention of Migraine Headache
  • Ergot alkaloid transport across ruminant gastric tissues
  • The Magical and Ritual Use Of Herbs
  • The Effects of Traditional Endophyte, Endophute - Free, and Novel Endophyte  Jesup Tall Fescue Hay Consumption on Digestion and Nitrogen Retention in Steers
  • The Psychedelic view
  • Modulation of Plant Ethylene Levels by the Bacterial Enzyme ACC Deaminase
  • Vaccination Against Ergot Alkaloids and the Effect of Endophyte-Infected Fescue Seed-Based Diets on Rabbits


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