Pentetic Acid - DTPA
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  • Pentetic acid or diethylene triamine pentaacetic acid (DTPA) is a polyamino carboxylic acid consisting of a diethylenetriamine backbone with five carboxymethyl groups. The molecule can be viewed as an expanded version of EDTA and it is used similarly.
  • DTPA is a calcium (Ca-DTPA) or zinc salt (Zn-DTPA) that is used to perform medical imaging of the brain, kidneys, and lungs. It is can also be used to remove certain radioactive materials, except uranium or neptunium, from a person’s body.
  • The conjugate base of DTPA has a high affinity for metal cations. Thus, the penta-anion DTPA5- is potentially an octadentate ligand. In contrast, EDTA possesses 6 centres to form coordination bonds with metals. The formation constants for its complexes are about 100 greater than those for EDTA.
  • DTPA is capable of binding to certain radioactive materials and speed up the release of these materials in the urine, thus reducing the amount of internal contamination.
  • As a chelating agent, DTPA wraps around a metal ion by forming up to eight bonds. Transition metals, however, usually have a limited coordination capacity and can form less than eight coordination bonds with ligands. So, after forming a complex with a metal, DTPA still has the ability to bind to other reagents, as is shown by its derivative pendetide.
  • Like the more common EDTA, DTPA is mainly used for sequestering metal ions that otherwise decompose hydrogen peroxide, which is used to bleach pulp in paper making. Several million kilograms are produced for this purpose annually.
  • DTPA is only available by injection and is not available in an oral (by mouth) form.
  • DTPA may be injected directly into a vein in the arm or dripped into a vein from a bag (intravenously [IV]). Injection and IV drip are good ways of treating people who might have been internally contaminated by eating, drinking, or inhaling radioactive materials or who have contaminated wounds.
  • In-CHX-A0-DTPA-labeled hu3S193 diabody and F(ab9)2 was also evaluated using a BALB/c nude mouse breast carcinoma xenograft model to ascertain their potential in targeting expressing solid tumors.
  • CHX-A0-DTPA was added in a molar excess of 3:1 and incubated at room temperature overnight, protected from light.
  • Excess unbound antibody was removed by dialysis for 8 h with 20 mM sodium acetate buffer containing 0.15 M NaCl (pH 6.4).
  • The pathophysiology and altered alveolar transfer to Tc-99m-DTPA radioaerosol in the acute and chronic phase of BLM-injured lungs have been well characterized.
  • Chelating agents, such as diethylenetriamine penta-acetic acid (DTPA), provide an indirect means of measuring total body storage iron.
  • A close and apparently specific relationship was found between DTPA- chelatable body iron and
    mobilizable storage iron in patients with iron excess, enabling the size of the stores to be reliably predicted.
  • Pentetic acids salts may be useful for enhancing removal of cobalt, einsteinium, lanthanum, nickel, promethium, scandium, strontium, ytterbium and yttrium but data are lacking and most of the data
    is from animal studies.


  • Diethylene triamine penta acetate
  • Description of Diethylene triamine penta acetate
  • Ingredients - Diethylene triamine penta acetic acid
  • Technetium 99m radiopharmaceuticals
  • Evaluation of Pentetic acid
  • Diethylene triamine penta acetate facts
  • DTPA factsheet
  • GSK vaccines key growth drives


  • Compositions for radiolabeling diethylenetriaminepentaacetic acid(dtpa)-dextran
  • Process for the manufacture of 117Sn diethylenetriamine pentaacetic acids
  • Formulation for Tin-117m /diethylenetriamine pentaacetic acids
  • Metal chelates of diethylenetriaminepentaacetic acid partial esters for NMR imaging
  • Photographic developers with titanous diethylenetriaminepentaacetic acid
  • Substituted DTPA monoamides of the central carboxylic acid group and their metal complexes
  • Oral DTPA for radionuclide chelation
  • Process for the production of DTPA-bis anhydride
  • Gadolinium-DTPA complex containing carborane unit, intermediates thereof and method of synthesizing them
  • Regioselective synthesis of DTPA derivatives


  • Use of diethylenetriamine penta-acetic acid (D.T.P.A.) in the clinical assessment of total body iron stores
  • Resistance of diethylenetriamine pentaacetic acid to anaerobic
  • Prospective Study of Simultaneous Orthoiodohippurate and Diethylenetriaminepentaacetic Acid Captopril Renography
  • Micro-SPECT/CT–Based Pharmacokinetic Analysis of 99mTc-
    Diethylenetriaminepentaacetic Acid in Rats with Blood–Brain Barrier Disruption Induced by Focused Ultrasound
  • Measurement of iron stores in cirrhosis using diethylenetriamine penta-acetic acid
  • Identification of the Soluble in Vivo Metabolites of Indium-111-Diethylenetriaminepentaacetic Acid-D-Phe1-Octreotide
  • Effect of captopril on 99mTc-diethylenetriaminepentaacetic acid renograms in two-kidney, one clip hypertension
  • Chitosan modified with gadolinium diethylenetriaminepentaacetic acid
    for magnetic resonance imaging of DNA/chitosan nanoparticles
  • Amine-Reactive Forms of a Luminescent Diethylenetriamine pentaacetic Acid Chelate of Terbium and Europium


  • Oral Ca-and Zn-DTPA: A Novel Tablet Formulation with Improved Decorporation of Americium-241
  • EPR of powers, crystals, clays of MRI contracts agents
  • EDTA and DTPA functionalized silica gel and chitosan adsorbents for the removal of heavy metals from aqueous solutions
  • DTPA forward placement project in New mexico
  • Prodrugs of DTPA as Radionuclide Decorporation Agents


  • Manufacturers of DTPA
  • Suppliers of DTPA
  • Exporters of DTPA
  • DTPA Suppliers
  • List of Suppliers

Company & Consultancy

  • Company1 from China
  • Company2 from China
  • Company from Michigan
  • Company1 from Mumbai
  • Company2 from Mumbai
  • Consultancy from Australia
  • Consultancy from U.K


  • Diethylenetriaminepentaacetic Acid, Pentasodium Salt
  • Diethylenetriaminepentaacetic acid MSDS
  • Diethylenetriaminepentaacetic acid
  • Diethylenetriaminepentaacetic acid datasheet
  • MSDS - Diethylenetriaminepentaacetic acid
  • Diethylene triamine penta acetic acid, 97%
  • Pentetic acid
  • Dissolvine D-FE-6


  • Tc-99m DTPA
  • Diethylenetriamine pentaacetate
  • Chelating agents
  • Diethylenetriamine pentaacetic Acid (DTPA)
  • Diethylenetriaminepentaacetic Acid basic information
  • D.T.P.A. Tc-99 labeling kit


  • Uptake of gadolinium-ethoxybenzyl-diethylenetriaminepentaacetic acid in metastatic adrenal tumour from hepatocellular carcinoma
  • Selective modification of NMR relaxation time in human colorectal
    carcinoma by using gadolinium diethylenetriamine pentaacetic acid
    conjugated with monoclonal antibody
  • Radioimmunotherapy with A-Particle Emitting 213Bi-CFunctionalized trans-Cyclohexyl-Diethylenetriamine pentaacetic Acid-Humanized 3S193 Is Enhanced by Combination with Paclitaxel Chemotherapy
  • Quantitative measurement of iron stores with diethylene triamine penta-acetic acid
  • Optical spectroscopy of neodymium(III) complexes with diethylenetriamine pentaacetic acid in solution and in [C(NH2)3]2[Nd(dtpa)(H2O)]P7H2O single crystal
  • Indium-111-Diethylenetriamine pentaacetic Acid-Octreotide Is Delivered in Vivo to Pancreatic, Tumor Cell, Renal, and Hepatocyte Lysosomes
  • Biodistribution Properties of 111Indium-labeled Diethylenetriaminepentaacetic Acid
  • Altered Clearance of Gadolinium
    Diethylenetriaminepentaacetic Acid Aerosol from Bleomycin-injured Dog Lungs
  • Adsorption characteristics of Ni2+ ion onto the diethylenetriaminepentaacetic acid-melamine / polyvinylidene fluoride blended resin

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