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Information @ a Glance

Contents on the CD Rom

  • Peptides are the family of short
    molecules formed from the linking, in a defined order, of various α-amino acids. The link between one amino acid residue and the next is an amide bond and is sometimes referred to as a
    peptide bond. The major classes of
    peptides are Ribosomal Peptides,
    Nonribosomal peptides, Digested
    peptides, Peptones, Peptide
  • Peptides have received prominence in molecular biology in recent times for several reasons. The first and most important is that peptides allow the creation of antibodies in animals without the need to purify the protein of interest. One can simply make
    antigenic peptides of sections of the protein of interest. These will suffice in making antibodies in a rabbit or mouse against the protein.
  • At the heart of the production
    technology is a solution-phase
    process, based on extensive use of
    persilylated amino acids. Free amino acids are undoubtedly the least expensive components with which peptide synthesis is performed. Since they are only soluble in water, they are not compatible with most coupling methods. Upon conversion to a fully silylated derivative, they
    become highly soluble in organic
    solvents. Trimethylsilylester offers the required protection and the reactivity of the trimethyl -silylamino function is sufficiently high to permit peptide bond formation.
  • Since the purity of the peptide
    obtained from the synthesis is
    sequence dependent, purification to >95% will be performed upon request. Major impurities can range from 10% to 50% by weight. They consist of small water soluble molecules, salts and protecting groups from the cleavage reaction, deletion peptides created due to incomplete coupling during synthesis, and modified peptides created during the cleavage.
    These species can be removed using reversed phase HPLC.
  • Hydrolysis of a peptide bond is slow but does occur. Store peptides as dry as possible at -20C or -70C. Desiccate if possible. Remember that hydrophobic peptides bind avidly to glass. Cysteinecontaining peptides will oxidize over time, even when stored at -20C. Long term storage of peptides in solution is not recommended regardless of the temperature.
  • Peptide mapping is an identity test for proteins, especially those obtained by r-DNA technology. It involves the chemical or enzymatic treatment of a protein resulting in the formation of peptide fragments followed by separation and identification of the fragments in a reproducible manner. It is a powerful test that is capable of identifying single amino acid changes resulting from events such as errors in the reading of complementary DNA (cDNA) sequences or point mutations.
  • The company recently introduced Amberchrom™ HPR10 Resin designed for therapeutic peptide or protein manufacture using
    recombinant DNA technology. There are several chromatography steps designed to isolate the product and establish its purity. This starts first with capture-concentration, and is followed by one or more intermediate purification steps, and is completed with final polishing.
  • Peptides have recently been used in the study of protein and function. For example, synthetic peptides can be used as probes to see where protein-peptide interactions occur. Inhibitory peptides are also used in clinical research to examine the effects of peptides on the inhibition of cancer proteins and other diseases.
  • Peptides are widely used in creating medicines where the total market size for peptide medicine is estimated to be approximately 10 billion USD. There are currently many types of manufacturing processes. These conventional synthetic methods require complicated steps for protection and deprotection of a protecting group in the amino acid and produce a high level of impurities
    and existence of the racemic mixtures. Standard purification procedures are very expensive and become impossible to meet this expanded demand for peptides easily with conventional peptide synthesis methods.
  • Avecia spin-out Reaxa has launched a new peptide coupling technology based on 2-mercaptobenzothiazole (2-MBT), which it claims offers major
    operational and cost benefits in both small and large scale solid-phase peptide synthesis.In addition to sub-licensing 2-MBT technology to peptide manufacturers, Reaxa offers a range of specialist services to support peptide drug discovery and process development - based largely on stakeholder Avecia's expertise in Fmoc solid-phase peptide synthesis.
  • Although peptide drugs have been on the market for decades - insulin being the most prominent example - it was not until 10 to 15 years ago that the pharmaceutical industry really started to work seriously on the development of a new generation of peptide-based
    therapeutics, prompted by advances in the understanding of the genetics of disease. But initial enthusiasm was soon dampened by the realisation that drug delivery technologies at that
    time were not up to the task of getting these relatively large compounds into the body effectively, while production
    could be complex and expensive.
 General Information
  • Peptide
  • Structure of peptide
  • Peptide design
  • Peptide synthesis
  • Essentials of Peptide Synthesis
  • Nomenclature and Symbolism for Amino Acids and Peptides

Production process

  • Innovative peptide production
  • Endogenous Production of Antimicrobial Peptides
  • Insulin C-peptide production in cell spheroids
  • Novel manufacturing process for the peptide production
  • Clinical batch production of peptide-loaded nanoparticles
  • Parathyroid Hormone-Related Peptide Production
  • Production of "ectopic" vasoactive intestinal peptide-like and neurotensin-like immunoreactivity
  • Calpain Inhibitor I Increases b-Amyloid Peptide Production
  • Oral delivery and recombinant production of peptide hormones
  • Reproducible Production of a PEGylated Dual-Acting Peptide


  • Peptide Synthesis
  • Peptide synthesis: from amino acids to function
  • Fluorous Peptide Synthesis
  • Strategy of peptide synthesis
  • Solid Phase Peptide Synthesis
  • Peptide synthesis reagents
  • Synthesis of peptides by transamination
  • Accelerated chemical synthesis of peptides and small proteins
  • Synthesis of antimicrobial peptides in the skin of Rana esculenta
  • Synthesis of peptide-oligonucleotide conjugates
  • Nonribosomal peptide synthesis in Aspergillus fumigatus and other fungi
  • Peptide Library Synthesis
  • Individually addressable parallel peptide synthesis on microchips
  • Nonribosomal Peptide Synthesis and Toxigenicity of Cyanobacteria
  • Peptide templated synthesis of oligosaccharides
  • Synthesis and Properties of Novel Peptide Nucleic Acids

Company Profiles

  • Affymax
  • American Peptide Company
  • Asubio Pharmaceuticals
  • Chinese Peptide Company
  • Digilab
  • GL Biochem (Shanghai) Ltd
  • Medicon Valley
  • Orpegen Pharma
  • TPI
  • United Biomedical


  • Jan Lipfert
  • Jon D. Stewart
  • Victor J. Hruby
  • James Joseph Cheetham
  • Michal Lebl
  • Experts in peptide synthesis
  • Bioprocess Technology Consultants
  • Indian Peptide Society


  • Peptide characterization
  • Hypothalamic control of energy balance
  • Molecular dynamics simulations of helical antimicrobial peptides in SDS micelles
  • Inhibition of Cell Cycle Progression by a Synthetic Peptide
  • Mechanisms of Antimicrobial Peptide Action and Resistance
  • Characterization of Precipitated from a Multiply Phosphorylated Peptides Selectively Pancreatic Casein Digest
  • Histidine-rich amphipathic peptide antibiotics promote efficient delivery of DNA into mammalian cells
  • Yeast Mitochondrial Leader Peptide Functions in Vivo as a Dual Targeting Signal


  • Unique Mucin Immunoenhancing Peptide with Antitumor Properties
  • Enzymatic Properties of Escherichia coli Peptide Deformylase
  • Properties of a Heparin-binding Peptide Derived from Bovine Lactoferrin
  • Novel properties of antimicrobial peptides
  • Prediction of signal peptide functional properties
  • Properties and Structures of the Influenza and HIV Fusion Peptides on Lipid Membranes
  • Surface Activity and Related Functional Properties of Peptides Obtained from Whey  Proteins
  • Functional Properties of Two Bombesin-Like Peptide Receptors
  • Structural properties of the chloroplast stromal processing peptidase

Material Safety Data Sheet

  • Peptide
  • C-peptide
  • ProteoHook
  • Peptide Pool “Classic”
  • Tau Peptide Series
  • CE – Peptide – Pool HLA-A24
  • Peptide Pool “Plus”
  • Calypte HIV-1 BED Incidence EIA
  • Double Antibody C-Peptide Urinary Diluent
  • Flu-P1 (Lyophilized)


  • BCN peptides production plants
  • Bioview system
  • Multi-products and multi-scale " launch plant"
  • Polypeptide Laboratories production plants
  • Synthetic tools and accessories
  • Neomps-peptide production plants
  • Amino acids
  • C-peptide
  • Resins
  • Biologically active peptides
  • Biologically active proteins
  • Carbohydrates and Conjugates
  • CLEAR resin
  • Eternox peptide repair creme
  • Enzyme inhibitors
  • Enzyme substrates and related compounds
  • Lists of inhibitors and substrates
  • Peptide antisera
  • Peptide Reagents
  • Peptide coupling reagents
  • Japanese Encephalitis Vaccine


  • Peptides
  • Peptide esterification
  • Peptide composition
  • Synthesis of peptides
  • Oxidation of peptides
  • Peptide vector
  • Pesticidal peptides
  • Process for synthesizing peptides or peptide derivatives
  • Peptides and processes for producing cyclic peptides
  • Therapeutically useful peptides and peptide fragments


  • Peptide mapping
  • Advancement in intermediate opioid peptide production in an enzymatic membrane reactor
  • Accelerated Analysis of peptide hydrolysates in less than 30 mins.
  • Apolipoprotein (apo) E4 enhances amyloid peptide production in cultured neuronal cells
  • Splicing of unnatural amino acids into proteins
  • Determination of Trifluoroacetic Acid (TFA) in Peptides
  • Novel resin technology for purification of peptides
  • Blocking with immunizing peptide protocol
  • Tamapin, a Venom Peptide from the Indian Red Scorpion


  • Peptide-immobilized nanoporous alumina membranes for enhanced osteoblast adhesion
  • Use of B-Type Natriuretic Peptide (BNP) in Practice
  • Uses of peptide in cosmetics
  • From Production of Peptides in Milligram Amounts for Research to Multi-Tons Quantities for Drugs of the Future
  • A New Treatment for Chemotherapy-Induced Enteritis
  • Industrial application of coupling reagents in peptides
  • Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal disorders1
  • Peptide therapy for anti-D replacement treatment
  • PepSets and their Applications


  • Peptide Ion Fragmentation for Proteomics Applications
  • 2 and 3 Peptide Cocktail Projects
  • Analysis of peptides in pig and mouse brain for the Peptidome database
  • Peptide Technology
  • Bio-based Functional materials from Engineered Self-Assembling Peptides
  • European union concerted action on peptide sensitisation
  • In Vivo Assessment of Anti-telomerase Peptide Nucleic Acids as a Novel Cancer Therapeutic Strategy
  • Synthesis of heterocyclic analogs of amino acids and peptides


  • The kindness of cows’ milk
  • Advion Biosciences and applied biosystems/MDS sciex to co-market automated chip-based nanoelectrospray to life science market
  • Peptide therapeutics market grows in fits and starts for drug firms and contract manufacturers
  • Indian drug cos prepare a peptide mix
  • Reaxa launches new peptide coupling agent
  • Peptide market finally ripening
  • Therapeutic Peptides under the Spotlight


  • Interpreting the Results of Peptide Analysis
  • Biotech desk catalog 2006-2007
  • Biologically functional peptides
  • Using Structural Biology to Combat Neglected Tropical Diseases
  • Market analysis of peptide
  • Mini-PEG report
  • TAG Copenhagen custom peptide modifications Price list
  • Peptide Competition Assay (PCA) report
  • Peptides International report
  • Soluta PSD delivers innovation in peptide chemistry
  • Peptide synthesis order
  • Custom Peptide Quotation Form
  • The abc's of peptide sequencing
  • Recent development of peptide coupling reagents in organic synthesis

Manufacturers and Suppliers

  • Peptide suppliers directory
  • Sell offers of peptides
  • Peptide sellers
  • Peptide synthesis reagent and peptide suppliers
  • Selling leads of peptide
  • Peptide station
  • Peptide wholesalers


  • Peptide: Handling and Storage recommendations
  • Low-priced peptides: affordable
  • General Guidelines for Cleaved PepSets
  • Peptide Pricing Guide
  • Peptide conjugation guidelines

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