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- Polyanhydrides are a
class of biodegradable polymers characterized by anhydride bonds
that connect repeat units of the polymer backbone chain.
- Their main application
is in the medical device and pharmaceutical industry. In vivo,
polyanhydrides degrade into non-toxic diacid monomers that can be
metabolized and eliminated from the body.
- Owing to their safe
degradation products, polyanhydrides are considered to be
biocompatible.
- Over the past two
decades, polyanhydrides have been investigated for short-term
controlled delivery of the bioactive agents because they exhibit
rapid degradation in vivo and have limited mechanical properties .
- Polyanhydrides are the
hydrophobic polymers with hydrolytically labile anhydride linkages,
in which the degradation rate can be manipulated by varying polymer
composition.
- Polyanhydrides are
known to undergo surface erosion, a desired property to attain near
zero-order drug
release profile .
- Recently, due to their
biocompatibility and biodegradability, the Food and Drug
Administration has approved the use of the polyanhydride derived
from sebacic acid and 1,3-bis(p-carboxyphenoxy) propane as the
carrier of antitumor agents for the treatment of brain cancer .
- One drawback of
polyanhydrides is that most of them have to be stored at frozen
state under the anhydrous condition
because of the hydrolytic instability of the anhydride bond.
- The main advantage of
using polyanhydrides for medical applications is that they gradually
degrade into nontoxic, small molecular weight products after their
intended use in drug delivery, obviating the need for retrieval.
- The most widely used
tech- nique for polyanhydride synthesis is melt polycondensation,
which occurs in two steps.
- In the first step,
dicarboxylic acid monomers react with excess acetic an- hydride to
form acetyl-terminated anhydride prepolymers with a degree of
polymerization.
- The activated monomers
are then polymerized at an elevated temperature (if necessary) under
vacuum to yield polyanhydrides
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General
- Introduction
- Polyanhydrides
- Drug delivery systems
- Synthesis,
Characterization and properties study on Novel Fluorescence
Polyanhydrides
MSDS & Products
- Polysebacic anhydride
- Zemac E60
- Ricon 131MA20
- Polyazelic
polyanhydride
- Hysol ES1301
- Cytec - product
- Gliadel - product
Patent
- Polyanhydrides with
therapeutically useful degradation products
- Polyanhydrides
- Aromatic
polyanhydrides
- Unsaturated
polyanhydrides
- Branched
polyanhydrides
- Fatty acid terminated
polyanhydrides
- Styrene-grafted
polyanhydride copolymer
- Thermosettable
epoxide-polyanhydride compositions
- Polyanhydrides with
biologically active degradation products
- Controlled drug
delivery high molecular weight polyanhydrides
Company profiles
- Company from China
- Company from New
Jersey
- Company from P.R.China
- Company from Texas
- Company from U.S.A
- Another Company from
U.S.A
Consultancy
- Consultancy from
Florida
- Consultancy from North
America
- Consultancy from U.K
- Online Consultancy
- List of Experts
- Experts list
Synthesis
-
Synthesis and
characterization of novel polyanhydrides with tailored erosion
mechanisms
-
Polyanhydride synthesis
techniques
-
Synthesis and erosion
properties of PEG containing polyanhydrides
-
Synthesis and degradation
characteristics of salicylic acid derived polyanhydride esters
-
Synthesis and cytotoxicity
of salicylate based polyanhydride esters
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Raw
material & Polyanhydride suppliers
- Acetic anhydride
- Dicarboxylic acid
- Suppliers of
Polyanhydrides
- Suppliers list
Report
- Xenogenics received
rights to Polyanhydride compounds drug delivery patent
- Biodegradable polymers
- Polyanhydrides
- Small angle X-ray
scattering to discern microstructure of semicrystalline
polyanhydrides for drug delivery
- A review of
photocrosslinked polyanhydrides in situ forming degradable networks
- Poly(ester-anhydride):
poly(amino ester) micro and nanospheres
- Photocrosslinked
polyanhydrides for spinal fusion
- Erosion and release
from biodegradable polyanhydrides
- Degradable polymer
microspheres for controlled drug delivery
- Crosslinked amino acid
containing polyanhydrides for controlled drug release applications
- Bioerodible
polyanhydrides for controlled drug delivery
Study
- Toxicological studies
of Polyanhydride nanoparticles for oral drug delivery
- Surface and bulk
modifications to photocrosslinked polyanhydrides to control
degradation behaviour
- Erosion kinetics of
hydrolytically degradable polymers
- Encapsulation,
stabilization and release of BSA-FITC from polyanhydride
microspheres
- Crosslinked
polyanhydrides for use in orthopedic applications
- Controlled release of
polypeptides from polyanhydrides
- Polyanhydride blends
as drug delivery matrices to control biofilms, bone and nerve
regenerations
- Biodegradable polymers
for microencapsulation of drugs
- Study on the
degradation rate of polyanhydride for potential drug delivery and
tissue engineering
- Analysis of fatty acid
anhydrides and polyanhydrides
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