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  • Atorvastatin is a member of the drug class known as statins, used for lowering blood cholesterol.
  • This lowers the amount of cholesterol produced which in turn lowers the total amount of LDL cholesterol.
  • HMG-CoA reductase catalyzes the reduction of 3-hydroxy-3-methylglutaryl-coenzyme A  to mevalonate, which is the rate-limiting step in hepatic cholesterol biosynthesis.
  • Inhibition of the enzyme decreases de novo cholesterol synthesis, increasing expression of low-density lipoprotein receptors on hepatocytes.
  • This increases LDL uptake by the hepatocytes, decreasing the amount of LDL-cholesterol in the blood.
  • Like other statins, atorvastatin also reduces blood levels of triglycerides and slightly increases levels of HDL-cholesterol.
  • A statistically significant negative correlation between market share and mean dose was found for atorvastatin and a positive correlation was found for fluvastatin (P<0.01).
  • Atorvastatin and cerivastatin consistently gained share at the expense of the other four brands over the two year period.
  •  HDL-C (good cholesterol) levels increased by up to 37% in combination drug-treated animals, while LDL-C (bad cholesterol) levels were
    further reduced by up to 24% with the combination, as opposed to atorvastatin alone.
  • Atorvastatin is indicated as an adjunct to diet for the treatment of dyslipidemia, specifically hyper cholesterol aemia.
  • It has also been used in the treatment of combined hyperlipidemia.
  • It is used for lowering blood cholesterol.
  •  Atorvastatin inhibits the rate-determining enzyme located in hepatic tissue that produces mevalonate, a small molecule used in the synthesis of cholesterol and other mevalonate derivatives.
  • Atorvastatin
  • Statins


  • Active Metabolite of Atorvastatin Inhibits Membrane Cholesterol Domain Formation by an Antioxidant Mechanism
  • Development of an efficient, scalable, aldolase-catalyzed process for enantioselective synthesis of statin intermediates
  • Effect of atorvastatin on apolipoprotein B100 containing lipoprotein metabolism in type 2 diabetes
  • Summary of Facts and Submissions
  • Prolonged inhibition of cholesterol synthesis explains the efficacy of atorvastatin
  • Immunoregulatory effects of atorvastatin on experimental autoimmune myocarditis in Lewis rats


  • Application of isolated perfused rat liver (IPRL) and in vivo rat studies following oral and intravenous administration
  • Atorvastatin Lowers C-Reactive Protein and Improves Endothelium-Dependent Vasodilation in Type 2 Diabetes Mellitus
  • Inhibition of Laser-Induced Choroidal Neovascularization by Atorvastatin by Downregulation of Monocyte Chemotactic Protein-1 Synthesis in Mice
  • Atorvastatin Improves the Course of Ischemic Acute Renal Failure in Aging Rats


  • Background for the December 17, 2002 Carcinogen Identification Committee Meeting Agenda Item
  • Modulation of the inflammatory process by statins
  • Phosphagenics reports superior pre-clinical cholesterol results from APA-01 and atorvastatin combination
  • An Assessment of Statin Safety
  • Statin pharmacology may have important clinical implications


  • Consultant From USA
  • Consultant From US
  • Consultant From USA
  • Consultant From US
  • Consultant From Israel

Technology & Patent

  • Atorvastatin inhibits angiotensin converting enzyme induction in differentiating human macrophages
  • Application of UV-Spectro photometry and RP-HPLC for Simultaneous Determination of Atorvastatin Calcium and Ezetimibe in Pharmaceutical Dosage Form
  • Polymorphic form of atorvastatin calcium
  • Process for the preparation of amorphous atorvastatin calcium
  • Preparation of atorvastatin
  • Pharmaceutical composition containing a combination of a statin and aspirin and method
  • Combination dosage form containing individual dosage units of a cholesterol-lowering agent, an inhibitor of the renin-angiotensin system, and aspirin


  • Managed Care Trends in Statin Usage
  • Polymorphic form of atorvastatin calcium
  • Phosphagenics reports superior pre-clinical cholesterol results from APA-01 and atorvastatin combination
  • Can Growth Be Sustained as Statin Patents Expire.
  • The Stain Drugs


  • Suppliers of Atorvastatin
  • Atorvastatin Suppliers
  • Manufacturers of Atorvastatin
  • Exporters of Atorvastatin

Company Profile

  • Company From India
  • Company From China
  • Company From India
  • Company From New Jersey

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