Ceramide
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Project at a Glance Contents on the CD ROM
  • Ceramides (pronounced ser-A-mid OR seramide) are a family of lipid molecules. A ceramide is composed of sphingosine and a fatty acid.
  • Ceramides are found in high concentrations within the cell membrane of cells. They are one of the component lipids that make up sphingomyelin, one of the major lipids in the lipid bilayer.
  • The most well-known functions of ceramides as cellular signals include regulating the differentiation, proliferation, programmed cell death (PCD), and apoptosis (Type I PCD) of cells.
  • There are three major pathways of ceramide generation. The sphingomyelinases
    pathway uses an enzyme to break down sphingomyelin in the cell membrane and
    release ceramide. The de novo pathway creates ceramide from less complex molecules.
  • Ceramide generation can also occur through breakdown of complex sphingolipids that
    are ultimately broken down into sphingosine, which is then reused by reacylation to form ceramide. This latter pathway is termed the Salvage pathway.
  • Ceramides are formed as the key intermediates in the biosynthesis of all the complex sphingolipids, in which the terminal primary hydroxyl group is linked to carbohydrate, phosphate etc.
  • The distinctive ceramides in the skin are derived mainly from glucosylceramide
    synthesized in specific organelles termed 'lamellar bodies' in the epidermal cells.
  • As a bioactive lipid, ceramide has been implicated in a variety of physiological functions including apoptosis, cell growth arrest, differentiation, cell senescence, cell
    migration and adhesion.
  • Ceramides are also produced during the catabolism of the complex sphingolipids, for example by the action of one or other of the sphingomyelinases or of phospholiphase on sphingomyelin in animal tissues as part of the sphingomyelin cycle.
  • Ceramides, like other lipid second messengers in signal transduction, are produced rapidly and transiently in response to specific stimuli in order to target specific proteins.
  • Because of its apoptosis-inducing effects in cancer cells, ceramide has been termed the "tumor suppressor lipid".
  • Several studies have attempted to define further the specific role of ceramide in the events of cell death and some evidence suggests ceramide functions upstream of the mitochondria in inducing apoptosis.
  • The lipid ceramide is widely recognized as being central for the mediation of the cellular stress response and the regulation of apoptosis in many cells. Ceramide has been demonstrated to be required for the cellular response to stress stimuli such as ionizing radiation, UVA-light, heat, and TNF receptor ligation.
 General
  • Ceramide.
  • Structure Biosynthesis and Function.
  • Ceramide- Its Cycles and Physiological Actions.
  • Ceramide-1 Phosphate.

MSDS

  • Ceramide Complex MSDS.
  • MSDS of Ceramide VI.
  • C-8 Ceramide Safety sheet.
  • Material safety sheet of Ceramide III.
  • Nervonic Ceramide MSDS.
  • Ceramide -C6 Msds.

Products

  • Ceramide-1-Phosphate .
  • Anti Ceramide MAb.
  • Ceramides.

Process

  • Preparation of Ceramide and sphingosine by chemical and biochemical methods.
  • Enzymatic production of Ceramide.

Toxicity

  • A New take on Ceramide.
  • Alzheimer's Disease, involving lipid toxicity.
  • Functional modulation of mitochondria by Eicosapentaenoic Acid provides protection against Ceramide Toxicity.

Patent

  • Ceramide  Cosmetic Compositions.
  • Ceramide 3 derivatives based on monounsaturated fatty acids.
  • Delivery system for high concentration of ceramide.
  • Combinations of ceramide and chemotherapeutic agents for inducing cell death.
  • Barley malt oil containing Vegetable ceramide.
  • Amino Ceramide-like compounds and therapeutic methods of use.
  • Ceramide Emulsions.
  • Topical Ceramide Compositions .
  • Enzymatic Synthesis of Ceramides.
  • Hair care compositions comprising ceramide.
  • Ceramide Dispersion.
  • Ceramide Precursor for improving natural epidermis.
  • Ceramides, process and their applications in the cosmetic.
  • Ceramide formulations suitable for oral administration.
  • Compositions related to inhibition of ceramide synthesis.
  • Topical application of Ceramides.
  • Methods for maintaining or increasing ceramide levels in skin.
  • Un-natural ceramide related compounds.

Technology

  • Omega Ceramide Technology.

Suppliers

  • Supplier from China.
  • Supplier from Japan.
  • Supplier from Korea.
  • List of Suppliers.
  • Supplier List1.
  • Supplier List2.
  • Supplier from UK.

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Company profiles

  • Company from USA.
  • Company from Singapore.
  • Company from South Korea.

Consultancy

  • Online Consultancy.
  • Consultancy from New York.
  • Consultancy from UK.

Report

  • Wheat germ-derived Ceramides.
  • Ceramides and Sphingosines.
  • Ceramide in malignant tumors.
  • Structure of a New Ceramide.
  • Ceramides-a new player in the inflammation-insulin resistance paradigm.
  • Ceramide Production in human retinal pigment epithelial cells.
  • Tips for maintaining an effective epidermal barrier.
  • Ceramide-A messenger of cell death.
  • Quantitation of free ceramides in human platelets.

Study

  • Ceramide accumulation is independent of camptothecin.
  • Ceramide synthesis and metabolism as a target for cancer therapy.
  • Apoptotic signal of Fas is not mediated by ceramide.
  • Ceramide and activated Bax act synergistically to permeablilize the mitochondrial outer membrane.
  • Radiation & ceramide-induced apoptosis.
  • Regulation of ceramide production.
  • Perturbation of sphingolipids metabolism and ceramide production.
  • Ceramide-mediated transport of chloride and bicarbonate across phospholipid membranes.
  • Lipid sorting by ceramide and consequences for membrane proteins.
  • Inverse relationship between ceramide synthesis and clinical severity in patients with psoriasis.
  • Ceramide induces Caspase-Dependent.
  • Ceramide signaling in Fenretinide-induced endothelial cell apoptosis.
  • Role of Sphingolipids and Ceramide in pulmonary inflammation in cystic fibrosis.
  • Ceramide-induced formation of ROS and ATP depletion.
  • Sphingomyelin hydrolysis to ceramide during the execution phase of apoptosis results.
  • Cannabinoids and ceramide: Two lipids acting hand-by-hand.
  • Visualization of Ceramide channels by transmission electron microscopy.
     

Uses

  • Application of skin-identical Ceramide3 for enhanced skin moisturization.
  • Detergent-resistant, ceramide-enriched domains in ceramide bilayers.
  • Synthetic Ceramide Analogues as Skin Permeation Enhancers.

 

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