Etoposide - Injections, Uses, Technology, Capsules, Process, Patent, Consultants, Treatments, Suppliers, Report

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Etoposide is a chemotherapy drug that is usually given to treat lung, ovarian and testicular cancer. Etoposide is a colourless fluid. It is also available as 50mg and 100mg pale pink capsules. Etoposide can cause a rash, which may be itchy. Etoposide is one of the most widely used antineoplastics. Etoposide is often incorrectly referred to as a topoisomerase inhibitor in order to avoid using the term "poison" in a clinical setting. Etoposide forms a ternary complex with DNA and the topoisomerase II enzyme, preventing re-ligation of the DNA strands. Etoposide must not be given by intra-cavity injection. Etoposide is contraindicated in patients with severe hepatic and/or renal dysfunction or in those patients who have demonstrated hypersensitivity to etoposide, podophyllotoxin, podophyllotoxin derivatives or any other component of this preparation. Etoposide is given by an intravenous (IV) infusion (a slow drip through a needle into your port or through a vein in your arm or hand) or infused intraperitoneal (IP; into your abdominal cavity by a special port placed in your abdominal wall), and it is also available in a pill form. Etoposide or etoposide phosphate may be used intravenously as a component of various chemotherapeutic regimens for the treatment of refractory testicular tumours in patients who have already received appropriate surgery, chemotherapy, and radiation therapy. The apoptotic process is induced by either etoposide or hydroxyurea in DA-1 lymphoma cells. The study of the apoptotic process in the murine cell line is of interest because of its sensitivity to the action of antitumor and toxic compounds. Etoposide microparticles containing poly(hydroxybutyrate-co-hydroxyvalerate) and poly( - caprolactone) were prepared by an emulsion/solvent evaporation process. Kinetic analysis of etoposide catechol formation by recombinant P450s was conducted using a highly sensitive, specific method based on liquid chromatography-tandem mass spectrometry (LC/MS/MS). Dexrazoxane pre-treatment significantly reduced the etoposide-induced MN formation, chromosomal aberrations and also the suppression of erythroblast proliferation in bone marrow cells of mice. A synthesized prodrugs of etoposide, a drug widely used to treat this cancer in humans. Etoposide is being used increasingly in the treatment of a variety of malignant conditions and in conjunction with autologous bone marrow transplantation. A semisynthetic derivative of podophyflotoxin, etoposide is also called Vepesid. A novel drug-development technology called the engineered peptide compound (EPiC) platformthat exploits the endogenous LRP-1 receptor-mediated transcytosis system. Etoposide-incorporated tripalmitin nanoparticles with negative (ETN) and positive charge (ETP) were prepared by melt emulsification and high-pressure homogenization techniques. Techniques such as chemotherapeutic peritoneal perfusion of anticancer agents have been used with little success, 2 , 3 and such techniques complicate the therapy by decreasing patient compliance. It is reported that to present a case of ovarian ectopic pregnancy successfully treated with laparoscopy-assisted local injection of etoposide. The use of adenovirus as a means of DNA transfer into cells has become a common technique in cell culture systems (1,2). While adenoviral-mediated gene transfer is more effective than traditional transfection techniques (e.g., liposome formation or calcium phosphate precipitation), infection of some cell types remains inefficient. The use of low doses of etoposide as a means to increase adenoviral gene expression without increasing cytotoxicity or apoptosis in cultured cells. Oral etoposide is an active single agent in small-cell lung cancer (SCLC) and is widely prescribed as first-line treatment as an alternative to intravenous combination chemotherapy in patients with extensive disease.	General Information About Etoposide Etoposide in combination with cisplatin, and bleomycin Etoposide FAQ Etoposide Injection Oral Etoposide Etoposide product characteristics Information for children and families Etoposide Process Dose enhancement effect of anticancer drugs associated with increased temperature in vitro Quantitation of Apoptosis Induction by Etoposide or Hydroxyurea in Mouse Interleukin 3-dependent Lymphoma Cells Etoposide Exposure Data Differentiation of U-937 promonocytic cells by etoposide and ICRF-193, two antitumour DNA topoisomerase II inhibitors with different mechanisms of action Primary WWOX phosphorylation and JNK activation during etoposide induces cytotoxicity in HEK293 cells Etoposide-Loaded Microparticles Prepared with Poly (Hydroxybutyrate- Co-Hydroxyvalerate) and Poly(ε-Caprolactone) Blends: Formulation, Characterization and in vitro Drug Release Discovery of Atg5/Atg7-independent alternative macroautophagy Pharmacokinetically guided dosing of carboplatin and etoposide during peritoneal dialysis and haemodialysis Kinetics and regulation of cytochrome p450-mediated etoposide metabolism Uses In vivo activity in a catalytic antibody-prodrug system: Antibody catalyzed etoposide prodrug activation for selective chemotherapy The effect of etoposide on human CFU-GM Inhibitory Effect of Polyunsaturated Fatty Acids on Apoptosis Induced by Etoposide, Okadaic Acid and AraC in Neuro2a Cells Etoposide (VP-16-213)-induced gene alterations: Potential contribution to cell death Etoposide causes illegitimate V(D)J recombination in human lymphoid leukemic cells Histopathological changes in the brain of mouse fetuses by etoposide-administration MSDS Etoposide 10Mm Etoposide Soft Gelatin Capsules Etoposide Etoposide 20mg/ml Concentrate for Solution for Infusion Toposar  Etoposide Injection USP Technology Influence of Dexrazoxane on Etoposide-Induced Chromosomal Instability in Mice New Angiopep-Modified Doxorubicin (ANG1007) and Etoposide (ANG1009) Chemotherapeutics With Increased Brain Penetration Etoposide-incorporated Tripalmitin Nanoparticles With Different Surface Charge: Formulation, Characterization, Radiolabeling, and Biodistribution Studies Tumoricidal Effects of Etoposide Incorporated Into Solid Lipid Nanoparticles After Intraperitoneal Administration in Dalton ’s Lymphoma Bearing Mice Identi¢cation of the genes responsive to etoposide-induced apoptosis: application of DNA chip technology Treatments Adenoviral transgene expression enhanced by cotreatment with etoposide in cultured cells Caspase Activation in MCF7 Cells Responding to Etoposide Treatment Ifosfamide/Etoposide combination in the treatment of recurrent malignant solid tumors of childhood The Course of Etoposide-induced Apoptosis from Damage to DNA and p53 Activation to Mitochondrial Release of Cytochrome Inhibition of etoposide-induced apoptosis with peptide aldehyde inhibitors of proteasome Five-Day Oral Etoposide Treatment for Advanced Small-Cell Lung Cancer: Randomized Comparison With Intravenous Chemotherapy Topotecan Increases Topoisomerase IIa Levels and Sensitivity to Treatment with Etoposide in Schedule-dependent Process The most reliable cancer treatment information	Capsules Etoposide Luscpoe Cisplatin/Etoposide SCLC (Oral) Vepesid® Vepesid 50 mg, 100mg Capsules Injections DBL® Etoposide Injection Etopophos Etosid ToposarTM Etoposide Etoposide 100mg Santop Consultant Consultant from America Consultant from Canada Consultant from Netherlands Consultant from USA Consultant from Texas Function Etoposide Induces Protein Kinase C - and Caspase-3- Dependent Apoptosis in Neuroblastoma Cancer Cells Effects of camptothecin, etoposide and Ca2+ on caspase-3 activity and myofibrillar disruption of chicken during postmortem ageing Etoposide induces chimeric Mll gene fusions High-dose tamoxifen as an enhancer of etoposide cytotoxicity. Clinical effects and in vitro assessment in p-glycoprotein expressing cell lines Hydrolytically activated etoposide prodrugs inhibit MDR-1 function and eradicate established MDR-1 multidrug-resistant T-cell leukemia Effects of prednisone and genetic polymorphisms on etoposide disposition in children with acute lymphoblastic leukemia A Role for the Interleukin 1 Receptor in the Synergistic Antitumor Effects of Human Interleukin 1 a and Etoposide against Human Melanoma Cells Report Management of a Type I Hypersensitivity Reaction to IV Etoposide in aWoman with a Yolk Sac Tumor: A Case Report Possible Role for p34cdc2 Kinase in Etoposide-induced Cell Death of Chinese Hamster Ovary Cells Global Analysis of Cellular Transcription Following Infection with an HIV-Based Vector Successful treatment of ovarian pregnancy with laparoscopy-assisted local injection of etoposide Trial of vindesine, etoposide and cisplatin in patients with previously treated, advanced stage, non-small bronchogenic carcinoma Etoposide sensitizes CT26 colorectal adenocarcinoma to radiation therapy in BALB/c mice Patent Etoposide oral dosage form Etoposide preparations Etoposide solutions Etoposide soft capsules Process of preparing etoposide phosphate and etoposide Use of etoposide Prodrugs of etoposide and etoposide analogs Acylated derivatives of etoposide Studies Etoposide Delivery to Tumour Cells using Biopolymer Nano-carriers Effects of P-glycoprotein Modulators on Etoposide Elimination and Central Nervous System Distribution Modulatory effect of quercetin on DNA damage, induced by etoposide in bone marrow cells and on changes in the activity of antioxidant enzymes in rats Efficacy and toxicity of mitoxantrone and oral etoposide in the treatment of hormone-refractory prostate cancer: pilot study Feasibility of intraventricular administration of etoposide in patients with metastatic brain tumours Suppliers Etoposide Suppliers Etoposide Sellers Etoposide Selling leads Etoposide Manufacturer & Suppliers Etoposide Exporters Order the CD-ROM Today
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