Glybenclamide
Technology,  Process, Patent, Application, Reports, Material safety Data sheet

Primary Information Services 

Home. Ordering Information. Contact    

Information @ a Glance

Contents on the CD Rom

  • Glibenclamide, also known as glyburide, is an anti-diabetic drug in a class of medications known as sulfonylureas, used in the treatment of type II diabetes.
  • Glyburide is in a class of drugs called sulfonylureas.
  • It is used to help control blood sugar levels.
  • Treatment with glyburide may increase the risk of death from cardiovascular disease compared to treatment of diabetes with diet alone or diet plus insulin.
  • The drug works by inhibiting ATP-sensitive potassium channels in pancreatic beta cells.
  • This inhibition causes cell membrane depolarization, opening of voltage-dependent calcium channels, thus triggering an increase in intracellular calcium into the beta cell which stimulates insulin release.
  • Inhibition of ATP-sensitive K channels  by an increase in cytosolic ATP4 or a decrease in Mg ADP and the resultant depolarization are essentially involved in the physiological mechanisms that lead to insulin secretion from pancreatic-cells.
  • To identify among women with gestational diabetes mellitus  the patient characteristics that predict treatment failure with glyburide.
  • Glyburide was more likely to fail in women diagnosed earlier in pregnancy, of older age and multiparity, and with higher fasting glucoses, suggesting that earlier glucose intolerance and a reduced capacity to respond to an insulin secretagogue may distinguish this group.
  • The whole-cell patch-clamp technique was used in adult mouse ventricular myocytes at 22°C to study the transient outward current and its sensitivity to the antimycotics miconazole and clotrimazole, as well as to glybenclamide.

Introduction

  • Glibenclamide
  • Glibenclamide
  • Glyburide

Process

  • Differential Effects of Glucose and Glyburide on Energetics and Na+ Levels of HC9 Cells
  • Preparation of nano crystals of glyburide by high energy controlled salting out  process and their characterization
  • Rosiglitazone, But Not Glyburide, Reduces Circulating Proinsulin and the Proinsulin
  • Effects Of The Sulfonylurea Glyburide On Catalase Activities in Streptozotocin-Induced Diabetic Rat Muscle
  • Synthesis of benzoic acid  and its analoguous labeling precursor

Application

  • Effect of glyburide and w3 fatty acid dietary supplements on glucose and lipid metabolism in patients with non- insulin dependent diabetes mellitus
  • Effects of the Combination of a Dipeptidyl Peptidase IV Inhibitor and an Insulin Secretagogue on Glucose and Insulin Levels in Mice and Rats
  • Mesenteric Arterial Relaxation to Calcitonin Gene-Related Peptide Is Increased During Pregnancy and by Sex Steroid Hormones1
  • A New Generation of Hypoglycemics
  • Stimulation of Bile Duct Epithelial Secretion by Glybenclamide in Normal and Cholestatic Rat Liver

Msds

  • Glyburide
  • Safety data for glyburide
  • Glyburide Msds
  • Glybenclamide

Report

  • ATP-binding Cassette Transporter A1  Functions as a Cholesterol Efflux Regulatory Protein
  • Effect of indomethacin on electrical field stimulation-induced contractions of isolated transverse and longitudinal rat gastric fundus strips
  • Glucose-dependent, mediated ATP efflux from Saccharomyces cerevisiae
  • Separately Inherited Defects in Insulin Exocytosis and -Cell Glucose Metabolism Contribute to Type 2 Diabetes
  • Predictors of Glyburide Failure in the Treatment of Gestational Diabetes
  • Role of K+ATP channels in coronary vasodilation during exercise

Patent & Technology

  • Glyburide composition
  • Synergistic effect of glyburide and milrinone
  • Composition and method for treating diabetes
  • Spray-dried lactose formulation of micronized glyburide
  • Pharmaceutical compositions for oral use, containing, in combination, met formin and glyclazide
  • Suppression of Transient Outward Potassium Currents in Mouse Ventricular Myocytes by Imidazole Antimycotics and by Glybenclamide
  • 31P and 23Na NMR Spectroscopy Demonstrate Glyburide Effects on Bioenergetics and Na+ Transport in Pancreatic Beta-HC9 Cells

Order the CD ROM Today

Primary Information Services
 21 Murugappan St, SwamyNagar Ext2, 
Ullagaram, Chennai - 600091, India.
 Phone: 91 44 22421080 
Email : informer@eth.net
Mobile numbers:9940043898, 9444008898  Fax : 91 44 22423753