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  • Glibenclamide, also known as glyburide, is an anti-diabetic drug in a class of medications known as sulfonylureas, used in the treatment of type II diabetes.
  • Glyburide is in a class of drugs called sulfonylureas.
  • It is used to help control blood sugar levels.
  • Treatment with glyburide may increase the risk of death from cardiovascular disease compared to treatment of diabetes with diet alone or diet plus insulin.
  • The drug works by inhibiting ATP-sensitive potassium channels in pancreatic beta cells.
  • This inhibition causes cell membrane depolarization, opening of voltage-dependent calcium channels, thus triggering an increase in intracellular calcium into the beta cell which stimulates insulin release.
  • Inhibition of ATP-sensitive K channels  by an increase in cytosolic ATP4 or a decrease in Mg ADP and the resultant depolarization are essentially involved in the physiological mechanisms that lead to insulin secretion from pancreatic-cells.
  • To identify among women with gestational diabetes mellitus  the patient characteristics that predict treatment failure with glyburide.
  • Glyburide was more likely to fail in women diagnosed earlier in pregnancy, of older age and multiparity, and with higher fasting glucoses, suggesting that earlier glucose intolerance and a reduced capacity to respond to an insulin secretagogue may distinguish this group.
  • The whole-cell patch-clamp technique was used in adult mouse ventricular myocytes at 22C to study the transient outward current and its sensitivity to the antimycotics miconazole and clotrimazole, as well as to glybenclamide.


  • Glibenclamide
  • Glibenclamide
  • Glyburide


  • Differential Effects of Glucose and Glyburide on Energetics and Na+ Levels of HC9 Cells
  • Preparation of nano crystals of glyburide by high energy controlled salting out  process and their characterization
  • Rosiglitazone, But Not Glyburide, Reduces Circulating Proinsulin and the Proinsulin
  • Effects Of The Sulfonylurea Glyburide On Catalase Activities in Streptozotocin-Induced Diabetic Rat Muscle
  • Synthesis of benzoic acid  and its analoguous labeling precursor


  • Effect of glyburide and w3 fatty acid dietary supplements on glucose and lipid metabolism in patients with non- insulin dependent diabetes mellitus
  • Effects of the Combination of a Dipeptidyl Peptidase IV Inhibitor and an Insulin Secretagogue on Glucose and Insulin Levels in Mice and Rats
  • Mesenteric Arterial Relaxation to Calcitonin Gene-Related Peptide Is Increased During Pregnancy and by Sex Steroid Hormones1
  • A New Generation of Hypoglycemics
  • Stimulation of Bile Duct Epithelial Secretion by Glybenclamide in Normal and Cholestatic Rat Liver


  • Glyburide
  • Safety data for glyburide
  • Glyburide Msds
  • Glybenclamide


  • ATP-binding Cassette Transporter A1  Functions as a Cholesterol Efflux Regulatory Protein
  • Effect of indomethacin on electrical field stimulation-induced contractions of isolated transverse and longitudinal rat gastric fundus strips
  • Glucose-dependent, mediated ATP efflux from Saccharomyces cerevisiae
  • Separately Inherited Defects in Insulin Exocytosis and -Cell Glucose Metabolism Contribute to Type 2 Diabetes
  • Predictors of Glyburide Failure in the Treatment of Gestational Diabetes
  • Role of K+ATP channels in coronary vasodilation during exercise

Patent & Technology

  • Glyburide composition
  • Synergistic effect of glyburide and milrinone
  • Composition and method for treating diabetes
  • Spray-dried lactose formulation of micronized glyburide
  • Pharmaceutical compositions for oral use, containing, in combination, met formin and glyclazide
  • Suppression of Transient Outward Potassium Currents in Mouse Ventricular Myocytes by Imidazole Antimycotics and by Glybenclamide
  • 31P and 23Na NMR Spectroscopy Demonstrate Glyburide Effects on Bioenergetics and Na+ Transport in Pancreatic Beta-HC9 Cells

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