Labetalol Hydrochloride                                                            
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Project at a Glance Contents on the CD ROM
  • Labetalol Hydrochloride is an adrenergic receptor blocking agent that has both selective alpha1- and nonselective beta-adrenergic receptor blocking actions in a single substance.
  • Labetalol Hydrochloride is a racemate, chemically designated as 5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl) amino] ethyl] salicylamide monohydrochloride.
  • Labetalol (Normodyne, Trandate, fixed combination with hydrochlorothiazide: Normozyde) is a mixed alpha/beta adrenergic antagonist, which is used to treat high blood pressure.
  • Labetalol HCl is a white or off-white crystalline powder, soluble in water.
  • Labetalol Hydrochloride Injection is used to lower high blood pressure, also
    called hypertension.
  • Labetalol Hydrochloride has a particular indication in the treatment of pregnancy-induced hypertension which is commonly associated with pre-eclampsia.
  • Labetalol Hydrochloride is also used to treat chronic and acute hypertension of pheochromocytoma and hypertensive crisis.
  • Labetalol blocks beta receptors that are found in the heart. This reduces the action of adrenaline and noradrenaline on the heart, causing it to beat more slowly and with less force. In turn, this reduces the pressure at which the blood is pumped out of the heart and around the body, which helps to reduce blood pressure.
  • Labetalol's action in slowing the rate and force of the heartbeat also reduces the energy used by the heart to pump blood
    around the body. This reduces the heart's need for oxygen, which means that labetalol can also be used in the management of
    angina. Angina is chest pain that occurs because the heart does not get enough oxygen to meet demand, for example during exercise.
  • Labetalol HCl Injection is contraindicated in bronchial asthma, overt cardiac failure, greater than first degree heart block, cardiogenic shock, severe bradycardia, other conditions associated with severe and prolonged hypotension.
  • Labetalol is considered a pregnancy Category C medicine by the U.S. Food and Drug Administration (FDA), which means that it might not be safe for use during pregnancy, although the full risks are currently unknown.
  • Labetalol was quicker and more efficient at controlling blood pressure, having a beneficial effect on renal functions and causing fewer side effects compared with methyldopa.
General Information
  • Labetalol basic Information
  • Labetalol Hydrochloride Information
  • Uses for Labetalol Hydrochloride
  • Labetalol Hydrochloride general information
Company Profiles
  • Company from India
  • Company from Australia
  • Company from China
  • Company from India
  • Company from Hong Kong

MSDS

  • Labetalol Hydrochloride
  • Trandate (labetalol hydrochloride) Tablets
  • Labetalol HCl Injection USP, 5mg/mL
  • Labetalol Injection 5mg/mL (20mL & 40mL)
  • Labetalol Hydrochloride Injection, USP
  • Labetalol Hydrochloride Injection, USP from USA
  • Labetalol Hydrochloride Injection, USP from USA

Product

  • Labetalol Hydrochloride Injection, USP
  • Gravidol, Labetalol Hydrochloride 100 mg Tablet
  • Labetalol Hydrochloride Injection, USP from USA
  • HYBLOC, Labetalol hydrochloride 50 - 400 mg Tablets
  • Labetalol Hydrochloride Injection, USP from Canada
  • 5mg/mL Labetalol Hydrochloride Injection
  • Presolol (active ingredient labetalol hydrochloride)
  • Trandate (labetalol hydrochloride) Injection
  • TRANDATE (labetalol hydrochloride) Tablets
  • Trandate Injection
  • Trandate Tablets
  • Trandate Injection from New Zealand
Patent
  • Sustained release labetalol tablets
  • Stable injectable labetalol formulation

Toxicity

  • Labetalol Hydrochloride Side Effects
  • Overview of Labetalol Side Effects

Suppliers

  • Suppliers  for Labetalol Hydrochloride
  • Labetalol Hydrochloride Suppliers
  • Suppliers and Manufacturer for Labetalol Hydrochloride
  • Suppliers  for Labetalol Hydrochloride

 

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Application

  • The use of oral labetalol in the treatment of  arrhythmias associated with the long QT syndrome.
  • Uses Of labetalol Hydrochloride
  • Labetalol in the treatment of patients with hypertension and renal functional impairment

Analysis

  • The α- and β-adrenoceptor blocking activities of labetalol and
    its RR-SR (50: 50) stereoisomers
  • Comparative Effects of Esmolol and Labetalol to Attenuate
    Hyperdynamic States After Electroconvulsive Therapy
  • Evaluation of IV cardene and Labetalol use in the Emergency Department
  • Optimization of Gastro Retentive drug delivery system of Labetalol hydrochloride using simplex centroid design
  • Propranolol versus Labeltalol : Interesting differences in efficacy
  • Voltammetric Determination of Labetalol in Pharmaceuticals and
    Spiked Human Urine
  • Formulation Development and Evaluation of Buccoadhesive tablets of Labetalol Hydrochloride

Effect

  • Effect pf Labetalol and propranolol on histamine-Induced bronchoconstriction in normal subjects
  • Electrophysiological effects of labetalol on canine atrial, cardiac Purkinje fibres and ventricular muscle
  • Effect of labetalol on the uptake of   [H]-(-)- Noradrenaline into the isolated vas deferens of the rat
  • Study of effects of post compression curing on Kollidon SR based floating tablets

Report

  • Approval for Labetalol Hydrochloride
  • Cost effectiveness of labetalol and propranolol the treatment of hyper- tension among blacks
  • Food and Drug Administration -  Labetalol Hydrochloride Tablets
  • Design and Development of Buccal Drug Delivery System for Labetalol using Natural polymer
  • Rapid development of pharmacy prepared labetalol injection
    as the solution for Trandate drug discontinuity
  • Sagent Pharmaceuticals announces FDA approval of LABETALOL Hydrochloride

Technology

  • Determination of Labetalol Hydrochloride by Kinetic Spectrophotometry Using Potassium Permanganate as Oxidant
  • Determination of Labetalol Hydrochloride in Drug Formulations by Spectrophotometry
  • Improved Liquid Chromatograhic Assay of Labetalol in Plasma
  • Spectrofluorimetric Determination of Labetalol in
    Pharmaceutical Preparations and Biological Fluids

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