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  • Nalidixic acid is the basis for quinolone antibiotics.
  • Nalidixic acid occurs as white to light yellow crystals or crystalline powder and it is odorless.
  • Nalidixic acid is sparingly soluble in chloroform and in N,N-dimethyl formamide, very slightly soluble in ethanol and in diethyl ether and practically insoluble in water.
  • Nalidixic acid, which was introduced into clinical use in 1967, was the first member of the quinolone group of antimicrobials. It is a specific inhibitor of bacterial DNA gyrase.
  • Nalidixic acid is bactericidal against Enterobacteriaceae, including many strains of Shigella spp.
  • Nalidixic acid has been used to interrupt DNA synthesis in exponentially growing cultures of E. coli.
  • The antibiotic, nalidixic acid (NAL), is a relatively specific inhibitor of DNA synthesis in Bacillus subtilis, leading to "unbalanced growth" in which cells continue to elongate and to synthesize RNA and protein.
  • The kinetics of loss of the chloroplast-associated DNA and the sensitivity of chloroplast replication to ultraviolet light was followed during treatment with nalidixic acid.
  • Nalidixic acid is effective against both gram-positive and gram-negative bacteria. In lower concentrations, it acts in a bacteriostatic manner; that is, it inhibits growth and reproduction. In higher concentrations, it is bactericidal, meaning that it kills bacteria instead of merely inhibiting their growth.
  • Nalidixic acid rapidly and specifically inhibits DNA synthesis in E. coli. Upon removal of the acid, DNA synthesis resumes rapidly and proceeds at a higher-than-normal rate.
  • Nalidixic and oxolinic acids inhibit DNA gyrase activity and induce formation of a relaxation complex analogue.
  • Nalidixic acid is especially used in treating urinary tract infections, caused, for example, by Escherichia coli, Proteus, Shigella, Enterobacter, and Klebsiella.
  • Nalidixic acid is also a tool in studies as a regulation of bacterial division and it is selectively and reversibly blocks DNA replication in susceptible bacteria.
  • Nalidixic acid and related antibiotics inhibit a subunit of DNA gyrase and induce formation of relaxation complex analogue.
  • The effect of nalidixic acid on pulse-labeled protein patterns was analyzed by sodium dodecyl sulfate-polyacrylamide slab gel electrophoresis.
  • Nalidixic acid also inhibits the nicking dosing activity on the subunit of DNA gyrase that release the positive binding stress on on the supercoiled DNA.
  • Nalidixic acid an antibacterial drug with a narrow spectrum is used mainly for urinary and intestinal infections.
  • Nalidixic acid resistance has been used as a selective marker for studies of pathogen-inoculated
    fruits and vegetables.
  • In past years, the use of the nalidixic acid screening test was recommended by the Clinical and Laboratory Standards Institute for the detection of invasive Salmonella isolates.
  • Nalidixic acid was the earliest introduced in India about two decades back followed by Norfloxacin in 1988 and later Ciprofloxacin was introduced for clinical use.
  • About nalidixic acid
  • Information about nalidixic acid
  • Nalidixic acid information
  • General information about nalidixic acid


  • Action of Nalidixic Acid on Chloroplast Replication in Euglena gracilis
  • Bactericidal Action of Nalidixic Acid on Bacillus subtilis
  • Mechanism of Action of Nalidixic Acid on Escherichia coli
  • Mechanism of action of nalidixic acid: Purification of Escherichia coli nalA gene product and its relationship to DNA gyrase and a novel nicking-closing enzyme
  • Nalidixic Acid-Induced Protein Alterations in Escherichia coli
  • Synchronous Reinitiation of Chromosome Replication in E. coli B/r after Nalidixic Acid Treatment

Company Profiles

  • Company from California
  • Company from Hungary
  • Company from India
  • Another company from India
  • Company from Japan
  • Company from Maharashtra

Consultants & Project

  • Consultant from Florida
  • Consultant from India
  • Another consultant from India
  • Consultant from USA
  • Consultant from Mumbai
  • Consultant from Woerden
  • The carcinogenetic potency project on nalidixic acid

Patent & Technology

  • 1,2-Ethanediamine salts of nalidixic acid
  • Mechanism of inhibition of DNA gyrase by analogues of nalidixic acid: The target of the drugs is DNA
  • A genomic approach to gene fusion technology
  • Quinolones and False-Positive Urine Screening for Opiates by Immunoassay Technology
  • Use of a MAMA-PCR Method to detect gyrA Mutations in Nalidixic Acid Resistant Clinical Isolates of Escherichia coli


  • Mechanism of phage Mu-I integration: Nalidixic acid treatment causes clustering of Mu-1-induced mutations near replication origin
  • The rheological effects of nalidixic acid on poly caprolactone
  • Effect of Nalidixic Acid on PBS2 Bacteriophage Infection of Bacillus subtilis
  • Pharmacokinetics of nalidixic acid in the dog
  • Photochemical Reaction of Nalidixic Acid in Methanol
  • Nalidixic Acid and Macromolecular Metabolism in Tetrahymena pyriformis: Effects on Protein Synthesis

Manufacturer's - Product information (msds)

  • Nalidixic acid
  • Nalidixic acid material safety data sheet
  • Nalidixic acid MSDS
  • Material safety data sheet for nalidixic acid
  • Safety data for nalidixic acid
  • MSDS for nalidixic acid
  • MSDS - Canada company
Turnkey Project Offer
  • Company in Maharastra
  • Company in Canada
  • Company in Mumbai
  • Company in Gujarat


  • Studies on molecular interactions between nalidixic acid and liposomes
  • Effect of Nalidixic Acid on DNA Replication by Toluene-Treated
    Escherichia coli
  • Novobiocin, Nalidixic Acid, Etoposide, and 4'-(9-Acridinylamino) methanesulfon-manisidide Effects on G2 and Mitotic Chinese Hamster Ovary Cell Progression
  • Some Properties of Subunits of DNA Gyrase from Pseudomonas aeruginosa PAO1 and Its Nalidixic Acid-Resistant Mutant


  • Predictive efficacy of nalidixic acid resistance as a marker of fluoroquinolone resistance in Salmonella enterica var Typhi
  • Nalidixic Acid Resistance Increases Sensitivity of Escherichia coli O157:H7 to Ionizing Radiation in Solution and on Green Leaf Lettuce
  • Specific inhibition of chloroplast replication in euglen a gracilis by nalidixic acid
  • Nalidixic Acid for Enrichment of Auxotrophs in Cultures of Salmonella typhimurium


  • Nalidixic acid ≥98%
  • BBL Todd Hewitt Broth with gentamicin and nalidixic acid
  • Nalidixic acid
  • Nalidixic Acid G.P.
  • Product of Nalidixic acid
  • Nalidixic acid BioChemika, ≥99.0% (T)
  • Ruz- Nalidixic acidŽ 500 MG TAB
  • Nalidixic acid product


  • Emergence of nalidixic acid resistance in shigella sonnei isolated from patients having acute diarrheal disease: Report from eastern province of saudi arabia
  • New Quinolone Resistance Phenomenon in Salmonella enterica: Nalidixic Acid-Susceptible Isolates with Reduced
    Fluoroquinolone Susceptibility
  • An outbreak of nalidixic acid resistant salmonella enterica serovar enteritidis at a nursery school in kitakyushu city, japan
  • Nalidixic acid resistant salmonella enterica serovar typhi with decreased susceptibility to ciprofloxacin caused treatment failure: a report from bangladesh
  • Nalidixic acid
  • Epidemiological Study of Resistance to Nalidixic Acid and Other Antibiotics in Clinical Yersinia enterocolitica O:3 Isolates
  • A Comparative Clinical Trial Between Piromidic Acid And Nalidixic Acid
  • Another 10thYear Anniversary:
    A NARMS Update


  • Toxicological Examinations of Oxolinic Acid and Nalidixic Acidin Ye1lowtail
  • Toxicity of Nalidixic Acid on Candida albicans, Saccharomyces cerevisiae, and Kluyveromyces lactis

Market Information

  • Prices, sellers,Buyer
  • Sourcing company
  • Supplier
  • Selling leads of nalidixic acid
  • India Information

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