Piperonyl butoxide
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  • Piperonyl butoxide (PBO) is an organic compound used as pesticide synergist, especially for pyrethroids and rotenone.
  • It does not by itself have pesticidal properties. However, when added to insecticide mixtures, typically pyrethrin, pyrethroid, and carbamate insecticides, their potency is increased considerably.
  • It is a semisynthetic derivative of safrole.
  • Piperonyl butoxide is a colorless to pale yellow liquid. It is practically insoluble in water and is stable to hydrolysis and ultraviolet irradiation.
  • Researchers consider piperonyl butoxide to be noncorrosive.
  • Piperonyl butoxide is a potent inhibitor of cytochrome P450 enzymes, which detoxify insecticides for many pests.
  • Therefore, inhibiting the P450s allows higher unmetabolised systemic concentrations of the insecticide (such as pyrethroid) to remain within the target animal for a longer period.
  • PBO is frequently used,especially in aerosol products and mosquito sprays, to increase the potency of pyrethrin and synthetic pyrethroids, as well as other types of insecticides.
  • Many different formulations of insecticide products contain
    PBO. These include dusts, sprays, foggers, repellents and pediculicides (lice killers); garden, lawn, ornamental plant, and,
    agricultural pesticides; mosquito abatement products, termite
    treatments, veterinary pesticides; and insecticides for human clothing, bedding, and mattresses.
  • According to surveys by the Environmental Protection Agency (EPA), PBO is one of the most commonly used ingredients in insecticides. It is currently found in approximately 1600 to 1700 registered pest control products.
  • On labels, PBO is sometimes listed as an active ingredient, but may also be considered an inert ingredient and not listed. PBO may also be listed as Butacide, Pybuthrin, ENT – 14250, and CAS Reg. No. 51-03-6.
  • Because of its widespread use, PBO is prevalent in the residential environment.
  • Exposure to an insecticidal synergist like PBO may make a person temporarily vulnerable to a variety of toxic insults that could otherwise be tolerated.
  • Not only does PBO kill organisms, it is known to interfere with the reproduction of many types of wildlife at much lower concentrations than those required for mortality.
  • PBO also inhibits the breakdown of toxic chemicals in wildlife and the soil, increasing the concentrations of other, more acutely potent, pesticides.
  • Although EPA maintains that the risk from chronic dietary and water exposure to PBO is very low, it is in dozens of products widely used in the home and community and not fully evaluated for synergistic effects.
  • It is commonly sprayed in insecticide formulations by municipalities as part of mosquito abatement. Children’s exposure to PBO is of concern because of their special vulnerability.
  • There was 127,500 kg of pyrethroids used in California agriculture in 2003, but only 2,700 kg of PBO, so it is clear that most of the agricultural pyrethroids are applied without a PBO synergist.
  • PBO acts as a hepatocarcinogen in rats fed a diet containing 1.2% PBO for two years and induces histopathological changes, such
    as hepatocellular enlargement, anisonucleosis, and single-cell
    necrosis, in the livers of imprinting control region (ICR) mice
    administered a diet containing 0.9% PBO for twenty days.
  • Although the mechanism of PBO induced hepatocarcinogenesis is not completely known, this compound is classified as a nongenotoxic carcinogen.
  • Introduction
  • Piperonyl butoxide
  • Pyrethrins and Piperonyl Butoxide
  • Safety of Pesticides used to control adult mosquitoes
  • Lice, Scabies and Pregnancy
  • The impossible gene
  • Types of Pesticides


  • Piperonyl Butoxide (PBO)
  • Lindane Alternatives: Health and Environmental Effects
  • Piperonyl Butoxide
    (Technical Fact Sheet)
  • Insecticide synergist factshet Piperonyl butoxide
  • Lice Killing Shampoo
  • McKesson Lice Killing Shampoo Drug Facts


  • Butacide
  • Drione
  • Drione MSDS
  • Kicker
  • Piperonyl butoxide MSDS
  • MSDS - Piperonyl butoxide
  • Pyrenone
  • Scourge
  • Sunivo
  • Piperonyl butoxide SC
  • Piperonyl butoxide tech 90%
  • Zoecon


  • Aerothor
  • Anvil
  • Avian
  • Ear drops
  • Epest solutions
  • Piperonyl butoxide
  • Piperonyl butoxide pharma grade GMP
  • Product list
  • Pyrethrins and piperonyl butoxide shampoo
  • Horse Shampoo FIEHSHP16
  • Pyrethrin and Piperonyl Butoxide Topical
  • Repel-X® Fly Spray
  • Piperonyl butoxide Information
  • Lice killing shampoo

Product labels

  • Aquapy
  • CVS
  • Excite
  • Good
  • Leader
  • McKesson
  • Pronto
  • Wallgreen


  • Use of piperonyl butoxide to protect plants
  • Cyclodextrin inclusion complex of piperonyl butoxide
  • Synergistic compositions comprising pesticidal 5-amino-4-ethylsulfinyl-1-arylpyrazoles and piperonyl butoxide
  • Propellent insecticide comprising o-cyclohexylcyclohexenone, pyrethrins and piperonyl butoxide
  • Insecticidal composition comprising ddt, pyrethrins, and piperonyl butoxide
  • Insecticidal Polymer Matrix Comprising PBO and DM
  • Insecticidal compositions containing 1-naphthyl-n-methylcarbamate and piperonyl butoxide as a synergist therefor
  • Paint composition
  • Arthropodicidal compositions


  • Piperonyl butoxide toxicity
  • Piperonyl butoxide chemical safety card
  • Piperonyl butoxide-ecological toxicity
  • Piperonyl butoxide with pyrethrins poisoning
  • Toxicity Profile for Piperonyl butoxide
  • Piperonyl Butoxide (PBO)
    Beyond Pesticides Rating: Toxic
  • Human Health Risk Assessment
  • FAO specifications and evaluations for agricultural pesticide: Piperonyl butoxide
  • Suppliers of Piperonyl butoxide
  • Manufacturers of Piperonyl butoxide
  • Selling leads of Piperonyl butoxide
  • Piperonyl butoxide Suppliers
  • Exporters of Piperonyl butoxide
  • Piperonyl butoxide Suppliers list
  • Indian supplier
  • Chinese supplier
  • Piperonyl butoxide exporters
  • Supplier from Pennsylvania
  • Trading leads
  • List of suppliers
  • Exporters list

Raw material suppliers

  • Butyldiglycol
  • Paraformaldehyde
  • Safrole
  • Sassafras oil

Company profiles

  • Company1 from China
  • Company2 from China
  • Company3 from China
  • Company4 from China
  • Company from Hangzhou
  • Company from India
  • Company from Italy


  • Consultancy from Belgium
  • Consultancy from Florida
  • Consultancy from U.S.A
  • Online Consultancy


  • Pesticides being proposed for Aerial spraying over south sacramento county among the most toxic
  • Duke Study Confirms Toxicity of Widely Used Pesticide Ingredient
  • Aerial spraying against mosquitoes may be used more quickly this year in Mass
  • Rhodia and Endura join forces for the production of eco-friendly Piperonyl Butoxide
  • Aerial Mosquito Spraying For West Nile Virus Criticized By Health And Environmental Advocates
  • Mass. DPH holds public hearing on mosquito policies in Raynham


  • Center for drug evaluation and research
  • Effect of Piperonyl butoxide on permethrin toxicity in the Amphipod Hyalella azteca
  • Environmental concentrations, Fate and Risk assessment of Pyrethrins and Piperonyl butoxide
  • Cytochrome P-450 mediates tissue-damaging hydroxyl radical formation during reoxygenation of the kidney
  • Bioassay of Piperonyl butoxide for possible carcinogenicity
  • Environmental exposures to Pyrethrins and Pyrethroids in the United states


  • Toxicological and biochemical studies on spinosad and synergism with piperonyl butoxide
  • Studies on the Inheritance of Carbamate-resistance in the housefly
  • Release of Piperonyl butoxide and Permethrin from synergized ear tags
  • Mechanistic Study on Hepatocarcinogenesis of Piperonyl Butoxide in Mice
  • Impact of Prenatal Exposure to Piperonyl Butoxide and Permethrin on 36-Month Neurodevelopment
  • Effects of Piperonyl Butoxide and Tetramethrin Combinations on Biological activities of Selected Synthetic Pyrethroid Insecticides against Different Housefly
  • Piperonyl butoxide report

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