- Trimethoprim is a
bacteriostatic antibiotic mainly used in the prophylaxis and treatment
of urinary tract infections.
- Trimethoprim was
commonly used in combination with sulfamethoxazole, a sulfonamide
antibiotic, which inhibits an earlier step in the folate synthesis
pathway (see diagram above). This combination, also known as
co-trimoxazole, TMP-sulfa, or TMP-SMX, results in an in vitro
synergistic antibacterial effect by inhibiting successive steps in
folate synthesis.
- Trimethoprim, combined
with a sulfonamide (sulfadiazine or sulfamethoxazole), is an antibiotic
used to treat respiratory, urinary tract, skin, and gastrointestinal
infections, and infections with coccidia.
- Trimethoprim, an
antibacterial drug, is a bacterial dihydrofolate reductase inhibitor
used as a prophylactic or to treat various bacterial infections
particularly urinary tract infections such as Proteus mirabilis.
-
The method involves for the determination of the
antibiotics enrofloxacin, oxytetracycline, and trimethoprim in aquatic
samples is solid-phase extraction (SPE) and preconcentration of
the antibiotics, separation by thin-layer chromatography (TLC) and
quantification by video densitometry.
- Cotrimoxazole, a
combination of sulfamethoxazole(SMZ) and trimethoprim (TMP), is widely
used for the treatment of not only urinary tract infections, but also
infections of the respiratory tract, septicemia, and gonorrhea .
- Trimethoprim-sulfamethoxazole(TMP-SMX), a drug regarded to
be the most efficient forthe chemoprophylaxis of Pneumocystis carinii
pneumonia
(PCP) in patients with HIV infection (5, 10, 18), stands
outbecause of its wide use.
- Trimethoprim,
2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine(TMP), widely used in
conjunction with sulfamethoxazole(SMX), is an effective antimicrobial
agent used, for example, in the treatment of urinary tract infections
and as a powerful bacteriostatic agent, because the antimicrobial
activity is greater than that when the sulfa-drug is used alone.
- Trimethoprim is often
used in combination with sulfamethoxazole to treat a wide variety of
aerobic gram-positive and gram-negative infections.
- The manufacture of
Trimethoprim involves three distinct stages;starting from Gallic Acid
which is converted into 3, 4, 5 Trimethoxy benzaldehyde and which in
turn is converted into Trimethoprim.
- Manufacture of 3, 4, 5
Trimethoxy benzaldehyde commences with methoxylation of Gallic Acid with
Dimethyl sulphate to obtain the intermediate product 3, 4, 5 Trimethoxy
benzoic acid.
-
The minimum inhibitory concentrations of sulfamethoxazole
and trimethoprim against 105 strains of Bacteroides spp. were determined
by an agar dilution Technique.
-
The assays are suitable for pharmacokinetic studies and
have been applied to determination of trimethoprim concentrations in
serum and urine during therapy with Co-trimoxazole, a sulfonamide/
trimethoprim preparation.
-
It is recognized that the disk diffusion technique is not
the best method for determining the susceptibility of anaerobes to some
antibiotics, it appears to be commonly used in Australia.
-
Nuclear magnetic resonance (NMR) techniques is used to
examine a trimethoprim (TMP)/E. coli dihydrofolate reductase (DHFR)
complex in its lyophilized, partially hydrated, polycrystalline, and
ammonium sulfate-precipitated states.
-
The combination of SCX-SPE clean-up coupled with LC-MS
technology is a suitable procedure for the screening and confirmatory
analysis of trimethoprim in muscle of swine.
- The anti-infectives
market is forecast to expand at a CAGR of 4.8% , driven largely by gains
in the anti-bacterial and anti-viral classes.
- Tamiflu, an established
product was the strongest performing brand in Roche’s anti-infectives
portfolio, with sales of $637.7m, on the back of increased demands for
the product as a treatment for avian influenza.
- The highest growth rate
in the global anti-bacterials drug class was reported by the
beta-lactams class of drugs which registered a growth rate of 12.8%
representing sales of $1,512m.
|
General
Information
- Trimethoprim and
Sulfamethoxazole(TMP/SMX) Fact Sheet
- Trimethoprim FAQ
- Trimethoprim - Product
Information
- Trimethoprim/Sulfadiazine and Trimethoprim / Sulfamethoxazole
(Tribrissen)
- About Trimethoprim
- Trimethoprim
Company
Profiles
- Company from USA
- Company from West
China
- Company from
China
- Indian Company from
Hyderabad
- Company from Karachi
Pakistan
- Company from US
- China Company from
Shandong
Process
- Synthesis and
Antibacterial Activity of new trimethoprim analogue
-
Characterization of a Staphylococcal
Trimethoprim Resistance Gene and Its Product
- Hydrogen-bonded
supramolecular motifs in trimethoprim-terephthalate-terephthalic
acid
-
Mechanism of the antimicrobial drug
trimethoprim revisited
-
Rapid antibiotic sensitivity testing
and trimethoprim-mediated filamentation of clinical isolates of the
Enterobacteriaceae assayed on a novel porous culture
support
-
Leucopenia Associated with
Trimethoprim- Sulphamethoxazole after Renal
Transplantation
- Trimethoprim
Process
Application
-
Double Blind Comparison Study of
Sulphonamide- Trimethoprim Combinations in Urinary Tract Infections in
the University of Santo Tomas Hospital
-
A Comparison of the Efficacy of
Trimethoprim- Sulfamethoxazole (Bactrim) and Chloramphenicol in the
Treatment of Typhoid fever
-
Two Distinct Types of
Trimethoprim-resistant Dihydrofolate Reductase Specified by R-Plasmids
of Different Compatibility Groups
-
Preparation and application of a
trimethoprim ion-selective piezoelectric sensor
-
Solid-Phase Extraction and TLC
Quantification of Enrofloxacin, Oxytetracycline, and Trimethoprim in
Wastewater
-
Absence of Effect of
Trimethoprim-Sulfamethoxazole on Pharmacokinetics of Zidovudine in
Patients Infected with Human Immunodeficiency Virus
-
Genetic Characterization of
Trimethoprim Resistance in Haemophilus influenzae
Technology
-
Assayfor Trimethoprimin Serumand
Urineby Meansof Ion-Pair Chromatography
TrimethoprimInterferes with Serum
MethotrexateAssaybythe Competitive ProteinBinding
Technique
Agar Dilution Susceptibility of
Bacteroides spp. to Sulfamethoxazole and Trimethoprim: Correlation with
a Disk Diffusion Technique
An Improved Technique for Isolation of
Environmental Vibrio cholerae with Epidemic Potential: Monitoring the
Emergence of a Multiple- Antibiotic–Resistant Epidemic Strain in
Bangladesh
Electrospray
LC-MS Determination of Trimethoprim in Muscle of Swine
The effect of hydration on the
dynamics of trimethoprim bound to dihydrofolate reductase A deuterium
NMR study
Material Safety Data Sheet
- Safety data for
trimethoprim
- Trimethoprim
- Sulfamethoxazole and Trimethoprim
Injection
- Trimethoprim Crystalline
- Gonococci Selective Supplement
- TECRAÒ Campylobacter Selective Supplement
- Tribrissen
Piglet Suspension
- Septrin Adult Suspension
Product
- Alprim
- Bactrim
- Polytrim
- Proloprim Tablet
- Sulfamethox With Trimethoprim
- Tucoprim
- Zotrim
|
Consultant & Project
- Consultant from
US
- Public Health and
Clinical Bacteriology Consultant
-
At what level of Trimethoprim
resistance would another treatment for cystitis become more cost
effective
- Molecular Epidemiology
and Antibiotic-resistance of Bacterial Infections in Georgia
Occurrence of Antibiotics in
Wastewater Effluents and Their Mobility in Soils
Pharmaceutical and Microbiological Pollution
Survey of the New York
City Watershed for the Presence of Pharmaceuticals
Patent
- Soft Contact Lens Ambient Temperature
Disinfectant and Rinsing Solution and Method
- Method for Enhancing Solubility of
Trimethoprim with sodium sulfacetamide and synergistic pharmaceutical
compositions derived therefrom
- Palatable Trimethoprim oral Solution
- Solution Containing Trimethoprim , Sulfacetamide
and Polymyxin
- Method and Composition for treating pneumocystic
carini infections
Health and Safety
Issues
- Sulfamethoxazole and Trimethoprim Tablets, USP
and Phenazopyridine Hydrochloride Tablets, USP
- Sulfonamide and Trimethoprim Combination (Oral
Route, Parenteral Route)
- Trimethoprim (eg in Bactrim, Septra, Septrin):
Martindale on side-effects
- Trimethoprim Sulfa
-
Sulfamethoxazole / Trimethoprim
-
Nottingham University Hospital NHS
Trust Patient Group Direction for Trimethoprim
Properties &
Function
- Chemical data sheet for Trimethoprim
-
Correlation of Trimethoprim and
Brodimoprim Physicochemical and Lipid Membrane Interaction Properties
with Their Accumulation in Human Neutrophils
- Trimethoprim Properties
-
Failure to Demonstrate a Consistent In
Vitro Bactericidal Effect of Trimethoprim-Sulfamethoxazole against
Enterococci
-
Effects of Sulfamethoxazole and
Trimethoprim on Human Neutrophil and Lymphocyte Functions In Vitro: In
Vivo Effects of Co-Trimoxazole
-
The Effect of Trimethoprim on
Macromolecular Synthesis in Escherichia coli
- Trimethoprim effect on deoxycytidine analog
renal clearance
-
The Effect of Trimethoprim /
Sulfamethoxazole on Friend Erythroleukemia Cells
-
The effect of hydration on the
dynamics of trimethoprim bound to dihydrofolate reductase
-
Trimethoprim resistance in Haemophilus
influenzae is due to altered dihydrofolate reductase(s)
Report & Market
- Trimethoprim-Induced Hyperkalemia in a Patient
with AIDS
- Fusarium Keratitis: a Case Report
- Trimethoprim-Induced Aseptic Meningitis in an
Adolescent Male
-
Recurrent pancreatitis after
trimethoprim sulfamethoxazole rechallenge
-
Reduction in the rate of customs duty
on trimethoprim
- Refractory
Hyperkalaemia Due to Trimethoprim, Successfully Treated with
Fludrocortisone
-
The Global Anti-infectives Market
Outlook to 2011
Suppliers
-
- Trimethoprim Traders
- Suppliers of Trimethoprim
- Trimethoprim Selling leads
- Exporters of Trimethoprim
- Trimethoprim Manufacturer / Suppliers
- Trimethoprim Suppliers Directory
- Trimethoprim Supplier list
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