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  • Trimethoprim is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections.
  • Trimethoprim was commonly used in combination with sulfamethoxazole, a sulfonamide antibiotic, which inhibits an earlier step in the folate synthesis pathway (see diagram above). This combination, also known as co-trimoxazole, TMP-sulfa, or TMP-SMX, results in an in vitro synergistic antibacterial effect by inhibiting successive steps in folate synthesis.
  • Trimethoprim, combined with a sulfonamide (sulfadiazine or sulfamethoxazole), is an antibiotic used to treat respiratory, urinary tract, skin, and gastrointestinal infections, and infections with coccidia.
  • Trimethoprim, an antibacterial drug, is a bacterial dihydrofolate reductase inhibitor used as a prophylactic or to treat various bacterial infections particularly urinary tract infections such as Proteus mirabilis.
  • The method involves for the determination of the antibiotics enrofloxacin, oxytetracycline, and trimethoprim in aquatic samples is  solid-phase extraction (SPE) and preconcentration of the antibiotics, separation by thin-layer chromatography (TLC) and quantification by video densitometry.
  • Cotrimoxazole, a combination of sulfamethoxazole(SMZ) and trimethoprim (TMP), is widely used for the treatment of not only urinary tract infections, but also infections of the respiratory tract, septicemia, and gonorrhea .
  • Trimethoprim-sulfamethoxazole(TMP-SMX), a drug regarded to be the most efficient forthe chemoprophylaxis of Pneumocystis carinii pneumonia
    (PCP) in patients with HIV infection (5, 10, 18), stands outbecause of its wide use.
  • Trimethoprim, 2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine(TMP), widely used in conjunction with sulfamethoxazole(SMX), is an effective antimicrobial agent used, for example, in the treatment of urinary tract infections and as a powerful bacteriostatic agent, because the antimicrobial activity is greater than that when the sulfa-drug is used alone.
  • Trimethoprim is often used in combination with sulfamethoxazole to treat a wide variety of aerobic gram-positive and gram-negative infections.
  • The manufacture of Trimethoprim involves three distinct stages;starting from Gallic Acid which is converted into 3, 4, 5 Trimethoxy benzaldehyde and which in turn is converted into Trimethoprim.
  • Manufacture of 3, 4, 5 Trimethoxy benzaldehyde commences with methoxylation of Gallic Acid with Dimethyl sulphate to obtain the intermediate product 3, 4, 5 Trimethoxy benzoic acid.
  • The minimum inhibitory concentrations of sulfamethoxazole and trimethoprim against 105 strains of Bacteroides spp. were determined by an agar dilution Technique.
  • The assays are suitable for pharmacokinetic studies and have been applied to determination of trimethoprim concentrations in serum and urine during therapy with Co-trimoxazole, a sulfonamide/ trimethoprim preparation.
  • It is recognized that the disk diffusion technique is not the best method for determining the susceptibility of anaerobes to some antibiotics, it appears to be commonly used in Australia.
  • Nuclear magnetic resonance (NMR) techniques is used to examine a trimethoprim (TMP)/E. coli dihydrofolate reductase (DHFR) complex in its lyophilized, partially hydrated, polycrystalline, and ammonium sulfate-precipitated states.
  • The combination of SCX-SPE clean-up coupled with LC-MS technology is a suitable procedure for the screening and confirmatory analysis of trimethoprim in muscle of swine.
  • The anti-infectives market is forecast to expand at a CAGR of 4.8% , driven largely by gains in the anti-bacterial and anti-viral classes.
  • Tamiflu, an established product was the strongest performing brand in Roche’s anti-infectives portfolio, with sales of $637.7m, on the back of increased demands for the product as a treatment for avian influenza.
  • The highest growth rate in the global anti-bacterials drug class was reported by the beta-lactams class of drugs which registered a growth rate of 12.8% representing sales of $1,512m.
General Information
  • Trimethoprim and Sulfamethoxazole(TMP/SMX) Fact Sheet
  • Trimethoprim FAQ
  • Trimethoprim - Product Information
  • Trimethoprim/Sulfadiazine and Trimethoprim / Sulfamethoxazole (Tribrissen)
  • About Trimethoprim
  • Trimethoprim

Company Profiles

  • Company from USA
  • Company from West China
  • Company from China
  • Indian Company from Hyderabad
  • Company from Karachi Pakistan
  • Company from US
  • China Company from Shandong


  • Synthesis and Antibacterial Activity of new trimethoprim analogue
  • Characterization of a Staphylococcal Trimethoprim Resistance Gene and Its Product
  • Hydrogen-bonded supramolecular motifs in trimethoprim-terephthalate-terephthalic acid
  • Mechanism of the antimicrobial drug trimethoprim revisited
  • Rapid antibiotic sensitivity testing and trimethoprim-mediated filamentation of clinical isolates of the Enterobacteriaceae assayed on a novel porous culture support
  • Leucopenia Associated with Trimethoprim- Sulphamethoxazole after Renal Transplantation
  • Trimethoprim Process


  • Double Blind Comparison Study of Sulphonamide- Trimethoprim Combinations in Urinary Tract Infections in the University of Santo Tomas Hospital
  • A Comparison of the Efficacy of Trimethoprim- Sulfamethoxazole (Bactrim) and Chloramphenicol in the Treatment of Typhoid fever
  • Two Distinct Types of Trimethoprim-resistant Dihydrofolate Reductase Specified by R-Plasmids of Different Compatibility Groups
  • Preparation and application of a trimethoprim ion-selective piezoelectric sensor
  • Solid-Phase Extraction and TLC Quantification of Enrofloxacin, Oxytetracycline, and Trimethoprim in Wastewater
  • Absence of Effect of Trimethoprim-Sulfamethoxazole on Pharmacokinetics of Zidovudine in Patients Infected with Human Immunodeficiency Virus
  • Genetic Characterization of Trimethoprim Resistance in Haemophilus influenzae


  • Assayfor Trimethoprimin Serumand Urineby Meansof Ion-Pair Chromatography
  • TrimethoprimInterferes with Serum MethotrexateAssaybythe Competitive ProteinBinding Technique
  • Agar Dilution Susceptibility of Bacteroides spp. to Sulfamethoxazole and Trimethoprim: Correlation with a Disk Diffusion Technique
  • An Improved Technique for Isolation of Environmental Vibrio cholerae with Epidemic Potential: Monitoring the Emergence of a Multiple- Antibiotic–Resistant Epidemic Strain in Bangladesh
  • Electrospray LC-MS Determination of Trimethoprim in Muscle of Swine
  • The effect of hydration on the dynamics of trimethoprim bound to dihydrofolate reductase A deuterium NMR study

Material Safety Data Sheet

  • Safety data for trimethoprim
  • Trimethoprim
  • Sulfamethoxazole and Trimethoprim Injection
  • Trimethoprim Crystalline
  • Gonococci Selective Supplement
  • TECRAÒ Campylobacter Selective Supplement
  • Tribrissen Piglet Suspension
  • Septrin Adult Suspension


  • Alprim
  • Bactrim
  • Polytrim
  • Proloprim Tablet
  • Sulfamethox With Trimethoprim
  • Tucoprim
  • Zotrim
Consultant & Project
  • Consultant from US
  • Public Health and Clinical Bacteriology Consultant
  • At what level of Trimethoprim resistance would another treatment for cystitis become more cost effective
  • Molecular Epidemiology and Antibiotic-resistance of Bacterial Infections in Georgia
  • Occurrence of Antibiotics in Wastewater Effluents and Their Mobility in Soils
  • Pharmaceutical and Microbiological Pollution
  • Survey of the New York City Watershed for the Presence of Pharmaceuticals


  • Soft Contact Lens Ambient Temperature Disinfectant and Rinsing Solution and Method
  • Method for Enhancing Solubility  of Trimethoprim with sodium sulfacetamide and synergistic pharmaceutical compositions derived therefrom
  • Palatable Trimethoprim oral Solution
  • Solution Containing Trimethoprim , Sulfacetamide and Polymyxin
  • Method and Composition for treating pneumocystic carini infections

Health and Safety Issues

  • Sulfamethoxazole and Trimethoprim Tablets, USP and Phenazopyridine Hydrochloride Tablets, USP
  • Sulfonamide and Trimethoprim Combination (Oral Route, Parenteral Route)
  • Trimethoprim (eg in Bactrim, Septra, Septrin): Martindale on side-effects
  • Trimethoprim Sulfa
  • Sulfamethoxazole / Trimethoprim
  • Nottingham University Hospital NHS Trust  Patient Group Direction for Trimethoprim

Properties & Function

  • Chemical data sheet for Trimethoprim
  • Correlation of Trimethoprim and Brodimoprim Physicochemical and Lipid Membrane Interaction Properties with Their Accumulation in Human Neutrophils
  • Trimethoprim Properties
  • Failure to Demonstrate a Consistent In Vitro Bactericidal Effect of Trimethoprim-Sulfamethoxazole against Enterococci
  • Effects of Sulfamethoxazole and Trimethoprim on Human Neutrophil and Lymphocyte Functions In Vitro: In Vivo Effects of Co-Trimoxazole
  • The Effect of Trimethoprim on Macromolecular Synthesis in Escherichia coli
  • Trimethoprim effect on deoxycytidine analog renal clearance
  • The Effect of Trimethoprim / Sulfamethoxazole on Friend Erythroleukemia Cells
  • The effect of hydration on the dynamics of trimethoprim bound to dihydrofolate reductase
  • Trimethoprim resistance in Haemophilus influenzae is due to altered dihydrofolate reductase(s)

Report & Market

  • Trimethoprim-Induced Hyperkalemia in a Patient with AIDS
  • Fusarium Keratitis: a Case Report
  • Trimethoprim-Induced Aseptic Meningitis in an Adolescent Male
  • Recurrent pancreatitis after trimethoprim sulfamethoxazole rechallenge
  • Reduction in the rate of customs duty on trimethoprim
  • Refractory Hyperkalaemia Due to Trimethoprim, Successfully Treated with Fludrocortisone
  • The Global Anti-infectives Market Outlook to 2011


  • Trimethoprim Supplier
  • Trimethoprim Traders
  • Suppliers of Trimethoprim
  • Trimethoprim Selling leads
  • Exporters of Trimethoprim
  • Trimethoprim Manufacturer / Suppliers
  • Trimethoprim Suppliers Directory
  • Trimethoprim Supplier list


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