Teniposide                                                                     Products , Market, Manufacturing Process, Plants Used, Suppliers, Company Profile, Reports, Equipment                                              Primary Information Services                                                   Home. Ordering Information. Contact

Project at a Glance

Contents on the CD Rom

  • Teniposide is a cancer (antineoplastic) medication. Teniposide interferes with the growth of cancer cells and slows their growth and spread in the body.
  • Teniposide is a white to off-white crystalline powder with the empirical formula C 32 H 32 O 13 S and a molecular weight of 656.66.
  • Teniposide is insoluble in water and ether. It is slightly soluble in methanol and very soluble in acetone and dimethylformamide.
  • Teniposide is FDA approved in combination with other anticancer agents for the treatment of childhood acute lymphoblastic leukemia that has stopped responding to standard therapies.
  • Teniposide produces its anti-cancer effects by inhibiting an enzyme, topoisomerase, which is responsible for maintaining structural function and integrity of DNA. By inhibiting the normal activity of topoisomerase, teniposide inhibits proper DNA synthesis, ultimately causing cellular death.
  • VUMON® (teniposide injection) (also commonly known as VM-26), is supplied as a sterile nonpyrogenic solution in a nonaqueous medium intended for dilution with a suitable parenteral vehicle prior to intravenous infusion.
  • Teniposide is a semisynthetic podophyllotoxin derived from the root of Podophyllum peltatum.
  • The American mayapple (Podophyllum peltatum L.; Berberidaceae) is a rhizomatous perennial species found throughout eastern North America.
  • Podophyllotoxin is an important plant compound that has found its way into different therapies. Up to the present the only source for podophyllotoxin is the Podophyllum plant, which is mainly collected from the wild.
  • Podophyllotoxin inhibits the formation of the microtubules. In vitro it binds to tubulin dimers giving podophyllotoxin-tubulin complexes.
  • Mandrake has a large brown root (like a parsnip), running 3 to 4 feet into the ground. The root is thick and is frequently forked like two legs.
  • Teniposide can reduce the production of white blood cells by the bone marrow, making you more prone to infection. Teniposide can reduce the production of platelets, which help the blood to clot.
  • Signs of an allergic reaction include skin rashes and itching, a high temperature, shivering, redness of the face, dizziness, headache, breathlessness and anxiety.
  • Teniposide is carcinogenic, fetotoxic, embryotoxic, and teratogenic and should not be used in pregnancy. It causes infertility.
Teniposide and its Products
  • Teniposide - Drug Dictionary
  • Teniposide - Drug Guide
  • Origins Origins of Pharmacology
  • Teniposide
  • Teniposide - drug
  • Teniposide - Monograph
  • Teniposide - Chemical Database
  • Vumon
  • Consumer Medicine Information
  • Teniposide Injection
  • HerbMedPro

Herbs Used

  • Propagule Type and Planting Time for Field-established Mayapple
  • The American Mayapple and its Potential for Podophyllotoxin Production
  • Podophyllum peltaturn
  • Growing Mandrakes Under Shoplights
  • Mandragora officinarum
  • Mandrake - Description
  • Mayapple
  • Podophyllum peltatum
  • Podophyllum
  • Podophyllum hexandrum
  • Podophyllum versipelle
  • Podophylli Rhizoma
  • Podophyllum Resin
  • Podophyllum resin MSDS
  • Podophyllam - Salicylic Acid - Cantharidin Mixture

Herb Suppliers

  • Suppliers Directory
  • S.S Herbals
  • Himachal Pharmaceutical Industries
  • Podophyllum Resin Suppliers
  • Eco-planet

Equipment Suppliers

  • Centrifuge Suppliers
  • Cheesecloth Suppliers
  • UV Light Source Manufacturers
  • Centrifuge Tubes and Holders
  • Medical Light Sources
  • Mortar and pestle
  • PH Meter Supppliers
  • Funnels: Plastic Suppliers


  • Enhanced Yield of Podophyllotoxin from Natural Products through in Situ Conversion Methods - Patent
  • Process for the isolation and Purification of Podophyllotoxin. - Patent
  • Synthesis of Podophyllotoxin Derivatives - Patent
  • A simple microanalytical technique for determination of podophyllotoxin
  • Recent advances in traditional plant drugs and orchids
  • The relevance of therapeutic drug monitoring in plasma and erythrocytes in anticancer drug treatment
  • Polyglutamate Drug Delivery Technology
  • Solvo Technology
  • Technology Report
  • Chimeric Tumor Suppressor
Synthesis and  Extraction
  • Podophyllotoxin BioSynthesis
  • Synthetic and plant cell culture synthesis
  • Assessment of Genetic Diversity in Podophyllum peltatum by Molecular Markers
  • Bioprospecting for Podophyllotoxin
  • Bioconversion of 2,7’- cyclolignans by heterologously expressed human cytochrome
  • American Mayapple Yields Anti-Cancer Extract
  • Podophyllum hexandrum Offers Radioprotection by Modulating
    Free Radical Flux
  • Podophyllotoxin and related lignans
  • The United States Drug Approval Process
  • Extraction of Chloroplasts from Plant Tissue and Their Use in Demonstrating the Hill Reaction

Market and Reports

  • Nature Spurs Cancer Drug Development
  • Natural and synthetic substances related
    to human health
  • General Policy Issues
  • Anticonvulsant Therapy Reduces the Effectiveness of Acute Lymphoblastic Leukemia Chemotherapy
  • World Journal of Surgical Oncology
  • Anticancer Drugs Induce Increased Mitochondrial Cytochrome c Expression That
    Precedes Cell Death1
  • Ionizing Radiation and Teniposide
    Promote Rb Dephosphorylation
  • Topoisomerase II trapping agent teniposide induces apoptosis and G2/M or S phase arrest of oral squamous cell carcinoma
  • Japan Clinical Oncology Group

Company Profiles and Suppliers

  • Shanghai SIPI Pharmaceutical Co., Ltd
  • Aphios Corporation
  • Hubei Xiangyun (Group) Chemical CO.,LTD
  • Shanghai Richem International Co.ltd
  • Manufacturers

Projects and Consultants

  • The Consultant Pharmacist
  • Cancer Consultant
  • Brent Alan Blumenstein, Ph.D.
  • Professor David Z. D'Argenio
  • Characterization of MRP3, a newly identified transporter of anti-cancer drugs
  • Pentacyclic triterpenoids from the family of boswellic acids as antitumor agents

Side Effects

  • Teniposide
  • Teniposide - Chemical Profile
  • Teniposide - Side Effects
  • Teniposide - Drug Information
  • Teniposide Drug - Side Effects



  Order the CD Rom Today

Primary Information Services
 21 Murugappan St, SwamyNagar Ext2, 
Ullagaram, Chennai - 600091, India.
 Phone: 91 44 22421080 
Email : informer@eth.net
Mobile numbers:9940043898, 9444008898  Fax : 91 44 22423753