- Teniposide is a
cancer (antineoplastic) medication. Teniposide interferes with the
growth of cancer cells and slows their growth and spread in the
body.
- Teniposide is a white
to off-white crystalline powder with the empirical formula C 32 H 32 O
13 S and a molecular weight of 656.66.
- Teniposide is
insoluble in water and ether. It is slightly soluble in methanol and
very soluble in acetone and dimethylformamide.
- Teniposide is FDA
approved in combination with other anticancer agents for the treatment
of childhood acute lymphoblastic leukemia that has stopped responding to
standard therapies.
- Teniposide produces
its anti-cancer effects by inhibiting an enzyme, topoisomerase, which is
responsible for maintaining structural function and integrity of DNA. By
inhibiting the normal activity of topoisomerase, teniposide inhibits
proper DNA synthesis, ultimately causing cellular death.
- VUMON® (teniposide
injection) (also commonly known as VM-26), is supplied as a sterile
nonpyrogenic solution in a nonaqueous medium intended for dilution with
a suitable parenteral vehicle prior to intravenous infusion.
- Teniposide is a
semisynthetic podophyllotoxin derived from the root of Podophyllum
peltatum.
- The American mayapple
(Podophyllum peltatum L.; Berberidaceae) is a rhizomatous perennial
species found throughout eastern North America.
- Podophyllotoxin is an
important plant compound that has found its way into different
therapies. Up to the present the only source for podophyllotoxin is the
Podophyllum plant, which is mainly collected from the wild.
- Podophyllotoxin
inhibits the formation of the microtubules. In vitro it binds to tubulin
dimers giving podophyllotoxin-tubulin complexes.
- Mandrake has a large
brown root (like a parsnip), running 3 to 4 feet into the ground. The
root is thick and is frequently forked like two legs.
- Teniposide can reduce
the production of white blood cells by the bone marrow, making you more
prone to infection. Teniposide can reduce the production of platelets,
which help the blood to clot.
- Signs of an allergic
reaction include skin rashes and itching, a high temperature, shivering,
redness of the face, dizziness, headache, breathlessness and
anxiety.
- Teniposide is
carcinogenic, fetotoxic, embryotoxic, and teratogenic and should not be
used in pregnancy. It causes infertility.
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Teniposide and its
Products
- Teniposide - Drug
Dictionary
- Teniposide - Drug
Guide
- Origins Origins of
Pharmacology
- Teniposide
- Teniposide -
drug
- Teniposide -
Monograph
- Teniposide - Chemical
Database
- Vumon
- Consumer Medicine
Information
- Teniposide
Injection
- HerbMedPro
Herbs Used
- Propagule Type and
Planting Time for Field-established Mayapple
- The American Mayapple
and its Potential for Podophyllotoxin Production
- Podophyllum
peltaturn
- Growing Mandrakes
Under Shoplights
- Mandragora
officinarum
- Mandrake -
Description
- Mayapple
- Podophyllum peltatum
- Podophyllum
- Podophyllum
hexandrum
- Podophyllum
versipelle
- Podophylli
Rhizoma
- Podophyllum
Resin
- Podophyllum resin
MSDS
- Podophyllam -
Salicylic Acid - Cantharidin Mixture
Herb
Suppliers
- Suppliers
Directory
- S.S Herbals
- Himachal
Pharmaceutical Industries
- Podophyllum Resin
Suppliers
- Eco-planet
Equipment
Suppliers
- Centrifuge
Suppliers
- Cheesecloth
Suppliers
- UV Light Source
Manufacturers
- Centrifuge Tubes and
Holders
- Medical Light
Sources
- Mortar and
pestle
- PH Meter
Supppliers
- Funnels: Plastic
Suppliers
Technology
- Enhanced Yield of
Podophyllotoxin from Natural Products through in Situ Conversion Methods
- Patent
- Process for the
isolation and Purification of Podophyllotoxin. - Patent
- Synthesis of
Podophyllotoxin Derivatives - Patent
- A simple
microanalytical technique for determination of podophyllotoxin
- Recent advances in
traditional plant drugs and orchids
- The relevance of
therapeutic drug monitoring in plasma and erythrocytes in anticancer
drug treatment
- Polyglutamate Drug
Delivery Technology
- Solvo
Technology
- Technology
Report
- Chimeric Tumor
Suppressor
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Synthesis and
Extraction
- Podophyllotoxin
BioSynthesis
- Synthetic and plant
cell culture synthesis
- Assessment of Genetic
Diversity in Podophyllum peltatum by Molecular Markers
- Bioprospecting for
Podophyllotoxin
- Bioconversion of
2,7’- cyclolignans by heterologously expressed human cytochrome
- American Mayapple
Yields Anti-Cancer Extract
- Podophyllum hexandrum
Offers Radioprotection by Modulating
Free Radical Flux
- Podophyllotoxin and
related lignans
- The United States
Drug Approval Process
- Extraction of
Chloroplasts from Plant Tissue and Their Use in Demonstrating the Hill
Reaction
Market and
Reports
- Nature Spurs Cancer
Drug Development
- Natural and synthetic
substances related
to human health
- General Policy
Issues
- Anticonvulsant
Therapy Reduces the Effectiveness of Acute Lymphoblastic Leukemia
Chemotherapy
- World Journal of
Surgical Oncology
- Anticancer Drugs
Induce Increased Mitochondrial Cytochrome c Expression That
Precedes
Cell Death1
- Ionizing Radiation
and Teniposide
Promote Rb Dephosphorylation
- Topoisomerase II
trapping agent teniposide induces apoptosis and G2/M or S phase arrest
of oral squamous cell carcinoma
- Japan Clinical
Oncology Group
Company Profiles
and Suppliers
- Shanghai SIPI
Pharmaceutical Co., Ltd
- Aphios Corporation
- Hubei Xiangyun
(Group) Chemical CO.,LTD
- Shanghai Richem
International Co.ltd
- Manufacturers
Projects and
Consultants
- The Consultant
Pharmacist
- Cancer
Consultant
- Brent Alan
Blumenstein, Ph.D.
- M. J. FINLEY AUSTIN,
Ph.D.
- Professor David Z.
D'Argenio
- Characterization of
MRP3, a newly identified transporter of anti-cancer drugs
- Pentacyclic
triterpenoids from the family of boswellic acids as antitumor
agents
Side
Effects
- Teniposide
- Teniposide - Chemical
Profile
- Teniposide - Side
Effects
- Teniposide - Drug
Information
- Teniposide Drug -
Side Effects
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