- Colchicum plant has a
large, ovate, solid, fleshy corm (tuber, according to some authors). The
leaves are dark-green, very smooth, obtuse,
above a foot long,
1 1/2 inches broad, keeled, and produced in the spring along with the
capsules. The flowers are several, radical, leafless,
and
bright purple, with a long, white tube appearing in the autumn without
the leaves.
- Colchicum root is About
25 Mm. (1 inch) long, ovoid, flattish, and with a groove on one side;
externally brownish and wrinkled; internally white and solid; often in
transverse slices, reniform in shape, and, breaking with a short, mealy
fracture; inodorous; taste sweetish, bitter, and somewhat acrid.
Colchicum seed is Subglobular, about 2 Mm. ( 1/12 inch) thick, very
slightly pointed at the hilum; reddish-brown, finely pitted,
internally whitish; very hard and tough; inodorous; taste bitter and
somewhat acrid.
- Gloriosa superba L. is
a semi-woody herbaceous branched climber, reaching approximately 5
meters in height. It is also planted outdoors in
the southern
United States. In cool temperate countries, it is treated as a
greenhouse or conservatory plant. In Bangladesh the plant is naturally
found to grow in Sal Forests of Dhaka and Gazipur districts. G. superba
is considered to be a herbaceous plant, little attention is given
towards its propagation and culture. It is commonly grown from seeds and
tubers.
- Three Different Methods
for extraction of Colchicine have been studied, and it was found that
extraction with petroleum ether and chloroform is the best and most
reliable method. Colchicine is readily converted into the corresponding
hydroxymethylene derivative, colchiceine, by hydrolysis of the
methoxymethylene group in dilute acid solution. The solution containing
colchicine and colchiceine is extracted by shaking with three separate
lots of 3 ml. chloroform.
- Wash-out of joints with
colchicine and diclofenac sodium significantly inhibit the increased
mediator activities. Both drugs also stimulate the recovery of the
degenerative changes. This effect of colchicine may be due to the
inhibition of leukocyte migration, glycoprotein production and secretion
in granulocytes. It has been shown that parenteral injection of
colchicine inhibits LTB4 a real mediator of vertebral disc
diseases.
- Rapid toxicity
technologies use various biological organisms and chemical reactions to
indicate the presence of toxic contaminants. The
toxic
contaminants are indicated by a change or appearance of
color or a change in intensity. As part of this verification test,
ToxScreen-II was
subjected to various concentrations of
contaminants such as industrial chemicals, pesticides, rodenticides,
pharmaceuticals, nerve agents, and biological toxins.
- A subsequent review of
medical records revealed that a third death from colchicine toxicity in
a patient treated at the Oregon clinic also
occurred in March
and likely was associated with the same compounding error. These deaths
highlight the potential risk from use of IV
colchicine for back
pain and the possibly fatal consequences of measuring errors in
compounding pharmacy products.
- World demand for
colchicine is still appreciably high today for the treatment of gout and
it is sourced as a raw material for the manufacture
of a drug
widely used in Europe for the treatment of spasticity and muscular
contractures.
- Colchicine have been
used as a probe to compare microtubules of PCI2 cells grown in the
absence and in the presence of NGF. The results of
this
comparison demonstrate that microtubules of long-term NGF-treated cells
(neurite-bearing) are much less susceptible to disruption
by
colchicine than are microtubules of cells grown in the
absence of NGF (nonneurite-bearing).
- Colchicine is Food and
Drug Administration (FDA)-approved for the treatment of gout and also
for familial Mediterranean fever, secondary amyloidosis(AA), and
scleroderma. Colchicine poisoning resembles arsenic poisoning; the
symptoms include burning in the mouth and throat, diarrhea,
stomach pain, vomiting, and kidney failure.
|
General
- Colchicine
Information
- Pharmacology of
Colchicine
- Colchicine Drug
Information
- Colchicine
- Colchicine Product
Information
- Colchicine
Plant Growth
and General Information
- Gloriosa superba
Linn
- Climbing Lily
- Gloriosa superba
L
- Glory lily Coastal
Curse
- Colchicum
-
Significance of sequential opening of flowers in Gloriosa
superba L.
-
Micropropagation of Gloriosa superba L. Through High
Frequency Shoot Proliferation
Processing and
Technology
- Phytochemistry of
Alkaloids
- The Conversion of
Colchicine into Colchiceine
- Estimation of
Colchicine in Six Different Species of Gloriosa Grown in Vitro
-
Techniques in
Karyology: The Bone Marrow Extraction Method
- Rapid Toxicity Testing
System
Company
Profiles
- Company in India
- Company at Calcutta,
India
- International
Pharmaceutical Company
- Company in
Germany
- Company at Mumbai,
India
- Manufacturer of Fine
Chemicals
Consultants
- Consultant in Northern
California
- Expert in polymer
synthesis, property design, degradation, flammability
- Consultant in
Cambridge, MA
- Rapid City Journal
Expert
Patent
- Antiproliferative
Colchicine Compositions and Uses thereof
- Colchicine Derivatives,
Process for Preparing them, Products obtained therefrom and Use
thereof
- Process for Extracting
Compounds from Plants
- Method of Enhancing
And/Or Prolonging Expression of Gene Introduced into a cell Using
Colchicine
- Colchicine Ophthalmic
Composition and Method of Use
- Process for the
Biotransformation of Colchicinoid Compounds into the Corresponding
3-glycosyl Derivatives
- Prolonged Local
Anesthesia with Colchicine
- Use of Colchicine for
the Control of Retroviruses
Functions
- Effect of Colchicine on
the Antibody Response
-
Chemical
Cross-Linking of Proteins of Semliki Forest Virus
- The Effect of
Colchicine on Ocular Growth and Emmetropization
-
Effects of
cytochalasins B and D and colchicine on migration of the corneal
epithelium
- Effect of Colchicine on
Iron Transport during Stages of Maturation and Enamel Pigmentation in
Rat Incisor Enamel
- The Mechanism of Action
of Colchicine
- Paradoxical Effects of
Colchicine on the activation of Human Neutrophils by Chemotactic Factors
and inflammatory Microcystals
Projects
- An Experimental System
to Study Phagocytosis
- Broadening the genetic
base, testing genotypes and developing breeding methods
-
From
Organelle to Protein Gel: A 6-Wk Laboratory Project on Flagellar
Proteins
- Development of an
internationally competitive saffron industry
- A Study of the Genetic
Improvement of Quaking and Bigtooth Aspen by Selection, Hybridization
and the Exploitation of Polyploidy
-
Colchicine
for alcoholic and non-alcoholic liver fibrosis and cirrhosis
|
Properties
-
A Convergent
Total Synthesis of (&)-Colchicine and ( f )-
Desacetamidoisocolchicine
- Total Synthesis of
Colchicine in Comparison
- Total Syntheses of
Colchicine
- Radioimmunoassay of
Colchicine
-
Colchicine-Induced Tetraploidy and Changes in Allele
Frequencies in Colchicine-Treated Populations of Diploids Assessed with
RAPD Markers in Gossypium arboreum
Applications
- Colchicine Use in
Children and Adolescents With Familial Mediterranean Fever
- Evidence that
Axoplasmic Transport of Trophic Factors is involved in the Regulation of
Peripheral nerve fields in Salmanders
-
Occurrence of
diploid and polyploid microspores in Sorghum bicolor (Poaceae) is the
result of cytomixis
-
Colchicine Is
a Competitive Antagonist at Human Recombinant g-Aminobutyric AcidA
Receptors
-
Topical
colchicine selection of keratinocytes transduced with the multidrug
resistance gene (MDR1) can sustain and enhance transgene expression in
vivo
-
Interest of
colchicine for the treatment of cystic fibrosis patients
- The Use of Colchicine
in Arthroscopic Wash-out Fluid in Early Degenerative Arthritis of the
Rabbit Knee Joint
Toxicity
- Acute Plant Poisoning
and Antitoxin Antibodies
- Fatal poisoning with
Colchicum autumnale
- Poisoning by Glory
Lily
- Colchicine Side Effects
& Drug Interactions
- Colchicine Treatment
and Toxicity
- Clinical Effects
Products and
Material Safety Data Sheet
- Ayurveda and natural
products drug discovery
- Colchicine
Tablets
- Colchicine
- USB Corporation-
Colchicine
- Colchicine 97%
- Safety data for
colchicine
- Colchicine ~95%
(HPLC), powder
Report
-
Changes
in the Colchicine Susceptibility of Microtubules Associated with Neurite
Outgrowth
- Entrepreneurship
Development through Medicinal and Aromatic Plants in North East
India
- Deaths from Intravenous
Colchicine Resulting from a Compounding Pharmacy Error
- Colon cancer:
Colchicine treatment possibilities
- In Vitro Delivery of
Nano- and Micro-Particles to Human Retinal Pigment Epithelial (ARPE-19)
Cells
- Regional Research
Laboratory Report
- ISMP 2007 survey on
HIGH-ALERT medications
Suppliers and Buyers
- Colchicine
Suppliers
- Colchicine Producer and
Manufacturer
- Colchicine Selling
Leads
- Colchicine
Exporters
- Colchicine
Manufacturers & Suppliers
- Kumar World Trade
- Manufacturers and
Suppliers of Colchicine
- Exporters of
Colchicine
- Colchicine Buyers
List
Gloriosa superba Suppliers
- Nath
International
- Gloriosa superba
Manufacturers & Suppliers
- Cultivators and
Exporters of Gloriosa superba
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