Project @ a Glance

Contents

• Ketamine hydrochloride, or "Special K," is a powerful hallucinogen widely used as an animal tranquilizer by veterinarians. Users sometimes call the high caused by Special K, "K hole," and describe profound hallucinations that include visual distortions and a lost sense of time, sense, and identity.
• Ketamine is a dissociative anesthetic developed in 1963 to replace PCP and currently used in human anesthesia and veterinary medicine. Much of the ketamine sold on the street has been diverted from veterinarians' offices.
• Ketamine's chemical structure and mechanism of action are similar to those of PCP Ketamine hydrochloride ("Special K" or "K") was originally created for use as a human anaesthetic.
• Ketamine belongs to a class of drugs called "dissociative anaesthetics," which separate perception from sensation. Other drugs in this category include PCP, DXM and nitrous oxide (laughing gas).
• Product resulting from grignard reaction involving o-chlorobenzonitrile &  bromocyclopentane is treated in presence of strong alkali to form epoxy cmpd. Reaction of this with methylamine yields imine which rearranges on heating in presence of hcl.
• Use of ketamine to treat severe cancer pain. The physiologic effects of the use of Telazol-ketamine-xylazine on feral cats in a large-volume spay and neuter clinic.
• The use of ketamine hydrochloride as an anesthetic for raccoons. Ketamine continues to be used extensively in children and for short-term anaesthesia and analgesia in-patients with burns.
• In veterinary anesthesia, ketamine is often used for its anaesthetic and analgesic effects on cats, dogs, rabbits, rats, and other small animals. Veterinarians often use ketamine with sedative drugs to produce balanced anaesthesia and analgesia, and as a constant rate infusion to help prevent pain wind-up. Ketamine is used to manage pain among large animals, though it has less effect on bovines.
• The effect of ketamine on the respiratory and circulatory systems is different from that of other anaesthetics. When used at anaesthetic doses, it will usually stimulate rather than depress the circulatory system. It is sometimes possible to perform ketamine anaesthesia without protective measures to the airways.
• Ketamine is sold in either powdered or liquid form. In powdered form, its appearance is similar to that of pharmaceutical grade cocaine and can be insufflated (referred to as a "SPECIAL K"), injected, or placed in beverages.
• There are three main types of ketamine infusion techniques currently being performed on RSD / CRPS patients for the relief of their pain and allodynia symptoms.
• Propofol-fentanyl-midazolam combination is found to be far superior to propofol-pethidine-midazolam and ketamine-midazolam combinations in respect to haemodynamic stability, oxygenation, shifting to PACU, incidence of complications and discharge readiness.
• Ketamine has been recommended as an alternative to thiopental sodium for the induction of general anesthesia in patients undergoing elective cesarean section. Compared to thiopental sodium induction, ketamine induction yields a significantly lower intraoperative maternal awareness and better neonatal outcome..

• Ketamine introduction
• Basics
• Club Drugs
• Ketamine
• Ketamine peril and promise

Process

• Ketamine Synthesis
• Method of manufacture - unapproved
• Production Process and Analysis
• A new synthesis for the preparation of optically pure (R)-2-(2-chlorophenyl)-2-(methylamino)cyclohexanone [(R)-Ketamine] as
  well as (S)-2-(2-chlorophenyl)-2-(methylamino)cyclohexanone [(S)-Ketamine]
• Stimulated Moving Bed Adsorption for Seperation of Racemic Mixtures
• Synthesis of Ketamine
• Total Synthesis of Ketamine

Ketamine Formulations

• Ketamine Powder
• Ketamine Hydrogels
• Ketamine Hydrochloride Injections
• Formulation for Mice
• Ketamine Gel
• Ketamine for Inhalation
• Compounded Oral Medicines
• Ketamine hydrochloride for injection
• Transdermal Patch

Consultants

• Consultant presentation
• Resource Centre
• Consultant in Barrington, Illinois
• Consultant in Arizona

Production

• The development of topical
  analgesics: molecule, formulation, dose-finding
• Ketamine
• Club Drugs: An Overview
• The Development of Single Enantiometer drugs from racemates
• Singapore: History of Illicit Drug

Properties and Functions

• Racemic ketamine
• Analgesic effect of caudal epidural ketamine in cattle
• Effects of Xylazine-Diazepam-Ketamine and Xylazine-Tiletamine-Zolazepam Anesthesia on Some Coagulation Parameters in Horses
• Ketamine Inhibits Inositol 1,4,5-Trisphosphate Production Depending on the Extracellular Ca21 Concentration in Neonatal Rat Cardiomyocytes
• Optimization of a simple method for the chiral separation of methamphetamine and related compounds in clandestine tablets
• Effects of Ketamine and Midazolam on Morphine induced dependence and Tolerance in Mice
• Ketamine Modulates the Stimulated Adhesion Molecule Expression on Human Neutrophils In Vitro
• Physical and psychological effects
• Effects on Human Performance and Behavior
• Ketamine suppresses intestinal NF-kappa B activation and proinflammatory cytokine in endotoxic rats
• Effects of ketamine on proinfl ammatory cytokines and nuclear factor kappaB in polymicrobial sepsis rats

Technical Information

• Monograph
• 2-methoxy ketamine hydrochloride
• Ketamine Infusion- Three Techniques
• Comparison of Various techniques sedation techniques for transvaginal oocyte retrieval in a daycare setup
• Low cost techniques
• Observations on the use of medetomidine/ketamine and its reversal with atipamezole for chemical restraint in the mouse
• A Comparison of Propofol and Ketamine as Induction Agents for Cesarean Section

Patents

• Ketamine Formulations
• Preparation of Ketamine Oinment
• Process for the preparation of ketamine ointment
• Ketamine analogues for the treatment of thrombocytopenia
• Use of ketamine for the manufacturing of medicaments for prevention or reduction of the effects of stroke in a subject having increased risk for stroke
• Ketamine and n-butyl-p-aminobezoate in PLO

Application

• The anti-inflammatory effects of ketamine
• Recent Evidence and
  Current Uses
• Combinations for Pain Management
• Ketamine in the Treatment of Refractory Cancer Pain
• Uses
• The physiologic effects of the use of Telazol-ketamine-xylazine on feral cats in a large-volume spay and neuter clinic
• Ketamine: the introduction and clinical use
• The Use of Ketamine Hydrochloride as an Anesthetic for Raccoons
• Therapeutic Uses of Ketamine
• Ketamine Special K Drug Use teens

Project Information

• Sample Prefeasibility report for API including 1000 KG per month of Ketamine
• Project information of API including Ketamine hydrochloride
• Prefeasibility Report
• API Project details Including Ketamine
• Ketamine hydrochloride
• Special K
• Product Profile

Material Safety Data Sheet

• Ketaset
• Ketamine Hydrochloride
• Ketamine Hydrochloride Injection, USP
• VetaKet® Injection
• Vetame

Suppliers

• Supplier of API
• Supplier - formulations
• Supplier of API

Policies and Rules

• Drug laws and rules
• Illicit Drug Policies
• Explanatory Memorandum to the Misuse of Drugs
• Regulation

Report

• Neuropathic Pain management
• Ketamine enantiomers in the rapid and sustained antidepressant effects
• Clinical Guidelines
• Expert Committee report
• Critical Review of Ketamine by WHO

Market

• Drug Market Report
• Uses of non-medical Ketamine
• Synthetic Drugs uses - Trends & Patterns
• New Psychoactive Substances
• Grey Market
• Other Drugs Market Information
• The Hong Kong Drug Market
• State Statutory Approaches to  Illicit Drug Policy