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Information @ a Glance

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• Aciclovir (INN)or acyclovir (USAN, former BAN), chemical name acycloguanosine, is a guanine analogue antiviral drug.
• Aciclovir was seen as the start of a new era in antiviral therapy.
  Aciclovir differs from previous nucleoside analogues in that it contains only a partial nucleoside structure.
• Acyclovir is poorly water soluble and has poor oral bioavailability.
  Acyclovir is available with a prescription under the brand name Zovirax.
• Acyclovir is prescribed as a cream or ointment (topical use), oral tablets, or intravenous liquid.
• Acyclovir-resistant pools of HSV typically represent heterogeneous mixtures of virus, and the antiviral-susceptibility curves and thymidine kinase biochemical assays of a given strain reflect the net composition of that pool.
• Acyclovir is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV. This viral enzyme converts acyclovir into acyclovir monophosphate, a nucleotide analogue.
• The comparability of systemic aciclovir exposure at steady state in immunocompromised patients has been evaluated.
• Two common hydrolytic enzymes were used as the catalysts for the transesterification of acyclovir.
• The antiviral action of acyclovir involves its enzymatic conversion into the triphosphate of acycloguanosine 9-[(2-hydroxyethoxy)methyl]guanine}.
• Acyclovir {9-[(2-hydroxyethoxy)methyl]guanine} is a synthetic purine nucleoside analog derived from guanine.
• Acylovir is indicated for the treatment of HSV and VZV infections.
• Taking acyclovir with food may decrease stomach upset.
  Acyclovir is used to treat infections caused by herpes viruses.
• Acyclovir is a purine nucleoside analogue with effects against human herpesvirus infections.
• Antiviral nucleoside acyclovir acts as a potential drug candidate for improving antiviral efficacy against herpetic epithelial and stromal keratitis.
• The use of acyclovir (ACV) has become an established part of clinical practice.
• HPLC technique is used for the determination of guanine nucleoside derivative acyclovir in serum, saliva and urine.
• Inderting Acyclovir twice a day by melt extrusion technique helps to improve patient complience using hydroxypropylcellulose as thermoplastic polymer.
• Suppression and reactivation of viral replication were evaluated by functional and molecular techniques.
• The effect of solvent polarity on the keto–enol tautomerism of N- and O-acetylated acyclovir derivatives has been studied through different spectroscopic technique.
• It has been reported that A 50-year-old woman developed rapidly progressive acute renal failure on the first day after the administration of intravenous acyclovir for acute left retinal necrosis.
• The proposed switching of oral acyclovir from prescription to over-the-counter (OTC) status for the 5-day episodic treatment of genital herpes was considered by a consensus panel.
• The antiviral activity of acyclovir requires that it first be converted to its monophosphate derivative by viral thymidine kinase.
• Adverse effects have been reported in patients receiving both large and low doses of acyclovir by both rapid and slow intravenous
  infusions as well as with oral use.

• Aciclovir - Antiviral Information
• Acyclovir Information
• Acyclovir (Zovirax®)/Valacyclovir (Valtrex®) and Pregnancy
• Aciclovir (topical)
• About Acyclovir
• Aciclovir

Company Profiles

• Company from Ontario
• Company from Singapore
• Company from Taiwan
• Company from Turkey
• Company from USA

Consultant

• Consultant from India
• Consultant from New York
• Consultant from USA
• Consultant from Washington

Process

• Comparable aciclovir exposures produced by oral valaciclovir and intravenous aciclovir in immunocompromised cancer patients
• Development of Effective Antiviral agents of a new type
• Electroporation and Transcutaneous sampling of acyclovir
• Enzyme-catalyzed Transesterification of Unusual Substrate: Synthesis of Acyclovir and L-ascorbic Acid (Vitamin C) Vinyl Esters
• Iontophoretic Delivery of Cream and Gel Formulations of Acyclovir
• Acyclovir: Mechanism of Action
• Synthesis and structural characteristics of metal–acyclovir (ACV) complexes: [Ni(or Co)(ACV)2(H2O)4]Cl2?2ACV, [Zn(ACV)- Cl2(H2O)], [Cd(ACV)Cl2]?H2O and [{Hg(ACV)Cl2}x]. Recognition of acyclovir by Ni–ACV
• Practical syntheses of antiviral nucleosides

Application

• Application for the inclusion of Aciclovir eye ointment in the WHO list of essential medicines
• Acyclovir Levels in Serum and Cerebrospinal Fluid after Oral Administration of Valacyclovir
• Randomized clinical trial of ganciclovir vs acyclovir for prevention of cytomegalovirus antigenemia after allogeneic transplantation
• Iontophoretic Application of Acyclovir Gel to Treat Cold Sores
• In Vivo Antiviral Efficacy of a Dipeptide Acyclovir Prodrug, Val-Val-Acyclovir, against HSV-1 Epithelial and Stromal Keratitis in the Rabbit Eye Model
• In Vitro Evaluation of Percutaneous Absorption of an Acyclovir Product using Intact and Tape-stripped Human Skin
• Co-Infection of Acyclovir-Resistant and Acyclovir-Sensitive Herpes simplex Type 2 Virus Strains in BS-C-1 Cells

• Potentiating Effect of Mizoribine on the Anti-Herpes Virus Activity of Acyclovir
• Potentiation of Antiviral Activity of Acyclovir by Polyene Macrolide Antibioticst
• Effect of Acyclovir on Viral Protein Synthesis in Cells Infected with Herpes Simplex Virus Type 1
• Effects of Acyclovir and Its Metabolites on Purine Nucleoside Phosphorylase
• Differential Effects of Acyclovir and 9-(1,3-Dihydroxy-2-Propoxymethyl)Guanine on Herpes Simplex Virus and Epstein-Barr Virus in a Dually Infected Human Lymphoblastoid Cell Line
• The Effect of the Interaction of Acyclovir with Zidovudine on Progression to AIDS and Survival: Analysis of Data in the Multicenter AIDS Cohort Study
• Ramsay Hunt Syndrome Treated with Oral Acyclovir

Material Safety Data Sheet

• Acycloguanosine
• Acyclovir
• Zovirax Capsules
• Acyclovir , [Side-Chain-2-3H]
• Acyclovir Sodium Injection

• Prescription of pharmaceutical benefits by authorised Optometrists Determination under subsections 85A(1) and (2) and 88(1C) of the National Health Act

• Acyclovir and Valacyclovir Pregnancy Registries

• Fetal Risk Summary

• Controversies in Management: Acyclovir for childhood chickenpox

• Management Strategies for Herpes Zoster and Postherpetic Neuralgia

Report

• Acyclovir-induced nephrotoxicity in a patient with acute retinal necrosis
• Perspectives on Switching Oral Acyclovir from Prescription to Over-the-Counter Status: Report of a Consensus Panel
• Practice parameter: Steroids, acyclovir, and surgery for Bell’s palsy (an evidence-based review)
• Recurrent Acyclovir-Resistant Genital Herpes in an Immunocompetent Patient
• Acyclovir Induced Reversible Renal Failure in an Immunocompromised Child with Extensive Cutaneous Herpes Zoster
• Full Clinical Recovery after Topical Acyclovir Treatment of Epstein-Barr Virus Associated Cutaneous B-Cell Lymphoma in Patient with Mycosis Fungoides

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