- BOTOX® is a drug known
most widely for its ability to temporarily smooth out facial wrinkles,
though it also has several medical applications. Both its cosmetic and
medical applications relate to Botox’s ability to block muscle
contractions.
- Botox belongs to a
class of products known as biologics—physiologically active substances
produced naturally by organisms (in this case bacteria) or synthetically
in the laboratory
- Botulinum toxin is a
neurotoxin protein produced by the bacterium Clostridium botulinum. It
is one of the most poisonous naturally occurring substances in the
world, and it is the most toxic protein. It is sold commercially under
the brand names Botox and Dysport for this purpose. The terms Botox and
Dysport are trade names and are not used generically to describe the
neurotoxins produced by the clostridia species.
- Botox blocks signals
from the nerves to the muscles. The injected muscle can no longer
contract, which causes the wrinkles to relax and soften. It is most
often used on forehead lines, crow's feet (lines around the eye) and
frown lines. Wrinkles caused by sun damage and gravity will not respond
to Botox.
- The market trend for
BOTOX® injection rates are up 31%, while alternatives such as chemical
peels are down 31%, and collagen injections, once very popular, have
dropped by 46%. The consumer can pay $5000 for a facelift to remove
lines and wrinkles now, or as an alternative can undertake twelve BOTOX®
injections over time.
- Consumers are avid for
non-invasive alternatives to Botox and cosmetic surgery, driving a
"cosmeceuticals" market destined to grow 8.5% to $5.1 billion by
2007.
- The increase in
popularity of nonsurgical procedures like Botox injections for wrinkles
is due to people becoming satisfied with less drastic measures to remove
wrinkles. From 2002 to 2003, the demand for Botox injections for
wrinkles resulted in a 153 percent increase, accounting for more than
887,000 procedures.
- Costs for botox can
vary significantly based on how much an individual needs and wishes to
get, and based on who is administering it. Some skin care centers
advertise low prices for botox on a "cost per area" basis, advertising
prices of $200-$300 for one area.
- The first rule of Botox
safety is that the procedure is perform only by a board certified
plastic surgeon who has experience with all aspects of the
Procedure.
- Botox is approved by
the U.S. Food and Drug Administration (FDA) to treat several medical
conditions (its “therapeutic” applications):
• Cervical Dystonia –
involuntary movement and prolonged muscle contraction of the neck, •
Blepharospasm – involuntary forcible closure of the eyelids, •
Strabismus – crossed eyes, • Hyperhidrosis – excessive sweating, •
Dynamic muscle contracture in pediatric cerebral palsy patients
(approved as an orphan drug) – an abnormality of motor function usually
acquired at a young age.
- Botox has been approved
for cosmetic applications in the following countries: Canada (2001), New
Zealand (2001), United States (2002), Australia (2002), Switzerland
(2002), Taiwan (2002), Singapore (2002), and France.
- Botulinum toxin type A,
brand name Botox®, is an effective preventative therapy for headache and
Migraine pain in chronic sufferers, according to the largest study
performed to date, presented at the 45th Annual Scientific Meeting of
the American Headache Society (AHS) in June.
- Botox is approved by
the Food and Drug Administration (FDA) for treatment of blepharospasm
(eyelid spasm), strabismus (crossed eyes), cervical dystonia (painful
neck spasms) and wrinkles between the eyebrows, but not for headache or
Migraine. Studies to obtain FDA approval for that use are
proceeding
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General
Information
- Botulinum toxin
- Mini botox
- Botox
alternatives
- Botulinum Toxin
- Botulinum Toxin
Primer
- Botulinum Toxin: Its
Nature and role in CP
- The Quick Fix:
Botox
-
Toronto
Botox
- BOTOX® Fact
Sheet
Production
Process
- Manufacturing Process
of Botox
- Growth of and Toxin
Production by Nonproteolytic Clostridium botulinum in Cooked Pure´ed
Vegetables at Refrigeration Temperatures
- Effects on Growth and
Toxin Production of Exposure of Spores of Clostridium botulinum Type F
to Sublethal Doses of Gamma Irradiation
- Clostridium botulinum
toxin development in refrigerated reduced oxygen packaged Atlantic
croaker
- Physiology of Toxin
Production by Clostridium Botulinum Types A and B
- The Effects of Modified
Atmosphere Packaging on Toxin Production by Clostridium botulinum in Raw
Aquacultured Flounder Fillets and Fully Cooked Breaded and Battered
Pollock Portions
- Refinement and
Reduction in Botulinum Toxin Testing
Functions and
Properties
Company
Profiles
- Nova Medical Skin
Care
- Accolade
Pharmaceuticals Pte Ltd
- Allergan, Inc
- EpiTan Ltd.
- Obagi Medical Products
Inc
Consultants
- Gerry E.Conti
- Fauquier ENT
Consultants
- List of
Consultants
- London Pain
Consultants
- K-T Solutions
- South Shore Medical Beauty Consultants
Patent
- Bioprocess for the
production of recombinant anti-botulinum toxin antibody
- Botulinum toxin
production method
- Leucine-based motif and
clostridial neurotoxins
- Cosmetic use of
botulinum toxin for treatment of downturned mouth
- Method for treating
hyperhidrosis in mammals
- Lipotox
Products and
Material Safety Data Sheet
- Botox Purified
Neurotoxin Complex
- Botox Injections
- Myobloc
- Botulinum Toxin Type
A
- Botox Products
List
- Anti Wrinkle 55
- Botox Cosmetic
- Botox Skin Care
Products
- BIOX Intensive
Anti-Aging Serum
- Data Sheet for Purified
Neurotoxin Complex
Technology
- Botox® injections
combined with surgery for migraine treatment
- New Uses Emerge for
Light-Emitting Diode Technology
- Botulinum toxin type B
micromechanosensor
- The Technology of
Beauty
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Applications
Market
- BOTOX®
Alternatives
- Exploring the Botox
Fad
- Botox In A Bottle: Driving Cosmeceutical
Growth
- Botox Injections for
Wrinkles
- Botox: How food
poisoning was tamed to make people look young
- Hotly contested market
for wrinkle removers
Report
- Allergen Annual Report
2006
- The Latest Buzz: About
Botox
- Botox: Medical
Officer's Review
- Summary of the NIAID
Expert Panel on Botulinum Toxins
- Allergen's Botox not
the cause of Botulism in Florida Patients
- Botox
- Botox Down Under
- Botox for Head Pain,
Largest Study Yet
- Is Any Cosmetic Better
Than Botox?
Projects
- Allergan Botox Ireland
- The effect of
multi-level botulinum toxin
- Evaluate the potential
of a quail embryo bioassay to replace the mouse bioassay for the
assessment of Botulinum toxin activity
- Regulation of Botulinum
Neurotoxin Expression
- Botox for the
brain
- The Compliance of the
use of Botulinum Toxins in BHR Trust against Local and National
Standard
Suppliers and
Buyers
- Broadway Botox
- Botox Selling
Leads
- Jingmen Ever-Young
Biotechnology Co., Ltd
- Botox Suppliers
-
- Botox Buyers
List
Hazards and
Risks
- Inhalational Poisoning
by Botulinum Toxin and Inhalation Vaccination with Its Heavy-Chain
Component
- Botulism
Poisoning
- Botox risks
Safety
Issues
- Botox Safety
- Safety and Efficacy of
Botox® Cosmetic
- Botox Cosmetic
Safety
- Efficacy and Safety of
Botox
- Botox Safety
Procedures
Guides
- Frequently Asked
Questions about Botox
- A Consumer's Guide to
Botox
- FAQ on Botox
Treatment
- Botox Treatment
Cost
- Guidelines for the use
of botulinum toxin (BTX) in the management of spasticity in
adults
- Botulinum Toxin
Injections Clinical Guideline
- Botulism Exposure
Guidelines
- Information on Botox
Injections
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