- Furosemide (INN) or
frusemide (former BAN) is a loop diuretic.
It is most commonly
marketed by Sanofi-Aventis under the brand name Lasix.
- The name of lasix is
derived from lasts six (hours) -- referring to its duration of
action.
- Furosemide is a
noncompetitive subtype-specific blocker of GABA-A receptors.
- Furosemide is odorless
white to slightly yellow crystalline powder.
- Furosemide is a
diuretic which is an anthranilic acid derivative.
It is practically
insoluble in water, sparingly soluble in alcohol, freely soluble in
dilute alkali solutions and insoluble in dilute acids.
- Furosemide may undergo
hydrolysis at sufficiently low pH.
The spherical agglomeration
process is used to delay the dissolution of furosemide.
- Hyperprostaglandin E
syndrome/antenatal Bartter syndrome (HPS/aBS), a salt-losing tubulopathy
of the furosemide type , is clinically characterized by polyhydramnios
leading to premature delivery, hypoisosthenuria with marked polyuria,
and severe hypercalciuria resulting
in nephrocalcinosis.
- Pre-systemic metabolism
of frusemide is carried out by the intestine while systemic clearance of
frusemide is mainly performed by the kidneys with contributions from the
intestine and the liver.
- The improving of the
solubility and UV stability of furosemide, a poorly water soluble
diuretic can be done by complexation with ß-cyclodextrin.
- A sensitive, selective
and efficient micellar liquid chromatographic (MLC) procedure was
developed for the determination of furosemide
(4-chloro-N-furfuryl-5-sulfamoylanthranilic acid) in urine samples by
direct injection and UV detection.
- Furosemide improves
medullary oxygenation by reducing oxygen consumption rather than by
increasing regional blood flow.
- Frusemide is commonly
used in conditions such as heart failure, where the pumping mechanism of
the heart is less effective.
- Frusemide is frequently
used to facilitate fluid and electrolyte management of acute renal
failure in many institutions.
Furosemide increases water content in
renal tissue.
- Urinary-system
elimination of 18F-FDG can be mistaken for pathologic uptake. Furosemide
helps eliminate this artifact.
- Chronic subcutane-ous
infusion of furosemide, with concomitant salt and water substitution,
was used to examine the isolated effect of prolonged inhibition of NaCl
transport in the cTALH/macula densa cells on expression of COX-2 in rat
kidney cortex.
- Frusemide has
significant bronchodilatory effect when given through inhaled route but
less effective than salbutamol.
- NIR spectroscopy
technique was used to evaluate 48 different formulations of furosemide
tablets.
- The short-term effects
of intravenous administration of furosemide on key functions in the
kidney cortex has been evaluated using magnetic resonance imaging (MRI)
technique.
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General
Information
- Chemical data sheet for
Furosemide
- Furosemide
Injection
- Furosemide
- About Furosemide
(Frusemide)
Company
Profiles
- Company from
California
- Company from
China
- Company from
Germany
- Company from
India
- Indian Company from
Mumbai
- Company from
Jordan
- Company from
Syria
- Company from USA
- Company from
Vadadora
Process
- Controlled release of
Furosemide from Spherical Agglomerates prepared by an oil agglomeration
process
- Biotransformation of Furosemide in Kidney
Transplant Patients
-
Further errors in polymorph
identification: furosemide and finasteride
-
Evaluation of furosemide regimens in
neonates treated with extracorporeal membrane oxygenation
- Meta-analysis of frusemide to prevent or treat
acute renal failure
-
Dominant Role of Prostaglandin
E
2
EP4 Receptor in
Furosemide-Induced Salt-Losing Tubulopathy: A Model for
Hyperprostaglandin E Syndrome / Antenatal Bartter Syndrome
-
Pharmacokinetic study of frusemide in
healthy and cirrhotic indian subjects
-
Synthesis and Characterization of Furosemide complexes in
β-cyclodextrin -
Determination of furosemide in urine
samples by direct injection in a micellar liquid chromatographic
system
Application
- Using Furosemide as a
Pre-contest Diuretic
- Continuous-Dose
Furosemide Attenuates TNF Levels in Acute Respiratory Distress Syndrome
(ARDS)
- An evaluation of the
interaction of meloxicam with frusemide in patients with compensated
chronic cardiac failure
-
A Furosemide - Sensitive Cotransport
of Sodium plus Potassium in the Human Red Cell
- Furosemide increases water content in renal
tissue
-
Intravenous Furosemide Injection
During 18F-FDG PET Acquisition
- Furosemide-Sensitive Cl Transport in Bovine
Retinal Pigment Epithelium
-
Rapid Oral Desensitization to Furosemide in a Patient with
Sulfonamide Allergy
-
Furosemide stimulates macula densa
cyclooxygenase-2 expression in rats
- The Role of Inhaled Frusemide in Management of
Bronchial Asthma
Material
Safety Data Sheet
- Safety data for furosemide
- Furosemide
- Disal (Furosemide) Injection Nada
- Lasix Tablets
- Disal (Furosemide) Tablets
- Furosemide Injection, USP
Patent
- Furosemide Modulators of HM74
- Process for the preparation of Furosemide
- Furosemide Salts
- Furosemide as tinnitus suppressant
- Urapidil/Furosemide compounds compositions and
uses
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Technology
- Changes in Intra-Renal oxygenation post
furosemide as evaluated by BOLD MRI : Effect of age and Inhibition of
prostaglandin synthesis
- Influence of hypertonic-hyperoncotic solution
and furosemide on canine hydrostatic pulmonary oedema resorption
- Furosemide-Loaded Microspheres were prepared by
the ionic cross linking technique : Morphology and Release
Characteristics
- Novel Spectrophotometric estimation of Frusemide
using hydrotropic Solubilization phenomenon
-
Process Analytical Technology (PAT)
Tools: Chemometric Evaluation of Furosemide Tablet Formulations
-
Furosemide-augmented Intravenous
Urography: Results in Essential Hypertension
Consultant & Project
- Consultant from
USA
- Consultant from New
Jersey
-
-
- The Carcinogenic
Potency Project - Furosemide
Product
- Frusemide BC
- Frusem 40
- FUSID®
- LASIX®
- Furosemide Oral Solution
Function
-
Effect of Intravenous Administration
of Frusemide on the Blood Sugar and Alloxan Diabetic Rabbits
-
Dilatory Effect of Furosemide on Rat
Tracheal Arterioles and Venules
-
Effects of acute hypovolaemia by
furosemide on tracheal transepithelial potential difference and mucus in
dogs
-
Inhaled frusemide does not affect lung
mucociliary clearance in healthy and asthmatic subjects
-
Effects of Furosemide on Distortion
Product Otoacoustic Emissions and on Neuronal Responses in the
Anteroventral Cochlear Nucleus
-
The effect of Frusemide on
Indomethacin Plasma Levels
Report
-
Furosemide in the Long-Term Management
of Heart Failure
-
Furosemide responsiveness,
non-adherence and resistance during the chronic treatment of heart
failure: a longitudinal study
-
Report of Case: Partial Ureteral
Obstruction Masked by Diuretics During Intraoperative Cystoscopy
-
Furosemide-induced bullous pemphigoid:
case report and review of literature
- Effects of cyclic AMP, ouabain and furosemide on
ion transport in isolated canine gastric mucosa
- Differential effect of frusemide on renal
medullary and cortical blood flow in the anaesthetised rat
Suppliers
- Suppliers of Furosemide
- Selling leads of Furosemide
- Exporters of Furosemide
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