- Imidazole is a organic
compound with the formula HC3H3N2. This aromatic heterocyclic is
classified as an alkaloid.
- Imidazole refers to the
parent compound whereas imidazoles are a class of heterocycles with
similar ring structure but varying substituents.
- This ring system is
present in important biological building blocks such as histidine, and
the related hormone histamine.
- Imidazole can be
synthesized by numerous methods besides the Debus method. Many of these
syntheses can also be applied to different substituted imidazoles and
imidazole derivatives simply by varying the functional groups on the
reactants.
- The Debus method forms
the (1,2), (3,4), and (1,5) bonds in imidazole, using each reactant as a
fragment of the ring, and thus this method would be a three-bond-forming
synthesis.
- One of the applications
of imidazole is in the purification of His-tagged proteins in
immobilised metal affinity chromatography(IMAC).
- Imidazole is used to
elute tagged proteins bound to Ni ions attached to the surface of beads
in the chromatography column.
- Imidazole has become an
important part of many pharmaceuticals.
- Imidazole has been used
extensively as a corrosion inhibitor on certain transition metals, such
as copper. Preventing copper corrosion is important, especially in
aqueous systems, where the conductivity of the copper decreases due to
corrosion.
- The toxicity observed
with imidazole carboxamide and vincristine included hematological
depression with leukocyte counts below 3,000/cu mm in 9 of 29
patients.
- The platelet counts
less than 100,000/cu mm in 8 of 29 patients, as compared to 8 of 26
patients with leukocytes below 3,000 and 13 of 26 patients with
platelets less than 100,000 utilizing CCNU.
- The present study was
designed to observe the clinical effects of 2 agents, imidazole
carboxamide and vincristine, as a combination program previously not
reported and a new nitrosourea, CCNU, in patients with disseminated
malignant melanoma.
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General
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- Information about
Imidazole
- Description about
Imidazole
- Imidazole
information
- General details of
Imidazole
Process &
Properties
-
Computer Simulation of the Imidazole
Catalysed Hydrolysis of Esters
-
Preparation of imidazolate-based ionic
liquid as a new proton conductive matrix
Synthesis of the Pyrrole-Imidazole Alkaloid
Sventrin from the Marine Sponge
Synthesis and properties of
2-substituted naphtho[2,3-d]imidazole and benzoxazole derivatives
Synthesis, spectral characterization
and redox properties of iron (II) complexes of
1-alkyl-2-(arylazo)imidazole
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Product
- Imidazole Buffered Saline
- Imidazole hydrochloride
Hydranal
Neolyst
QuickPick™ IMAC Plus
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MSDS
Imidazole Buffer
CK NAC
EPO-TEK 380
Safety data for
imidazole
Imidazole Buffered Saline
MSDS for
Imidazole
MICROSHIELD Skincare Cleanser
4M Imidazole Stock Solution
Application
-
Addition of imidazole during binding
improves purity of histidine-tagged proteins
Imidazole Curing Agents
for Epoxy Resins
Molecular Biology
applications
Novel nitrogen ligands based on
imidazole derivatives and their application in asymmetric
catalysis
Optical recognition elements.
Macrocyclic imidazole chromoionophores entrapped in silica
xerogel
Patent
Imidazole compounds and
textile treatment compositions
1,4,5 tri-substituted
imidazole compounds useful as cytokine
Process for preparing
4-substituted imidazole compounds
Process for the
isolation and purification of an imidazole stereo isomer
Substituted Imidazole
compounds
Report
-
A Comparative Study of
l-(2-Chloroethyl)-3-cyclohexyl-l-nitrosourea (NSC 79037) and Imidazole
Carboxamide (NSC 45388)with Vincristine (NSC 67574) in the Palliation of
Disseminated Malignant Melanoma1
-
Infrared study of the binuclear
cadmium(II) imidazole saccharinato complex
-
Critical evaluvation of stability
constants of metal-imidazole and metal-histamine systems
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