- Salicylic acid is the
chemical compound with the formula C6H4(OH)CO2H, where the OH group is
adjacent to the carboxyl group. This colorless crystalline organic acid
is widely used in organic synthesis and functions as a plant hormone. It
is probably best known as a compound that is chemically similar but not
identical to the active component of aspirin. The name derives from the
Latin word for the willow tree (Salix), from whose bark it can be
obtained.
- Salicylic acid
crystallizes in small colorless needles which melt at 1 55° C. It is
sparingly soluble in cold water, but readily dissolves in hot. It
sublimes, but on rapid heating decomposes into carbon dioxide and
phenol. Ferric chloride colours its aqueous solution violet. Potassium
bichromate and sulphuric acid oxidize it to carbon dioxide and water;
and potassium chlorate and hydrochloric acid to chloranil. On boiling
with concentrated nitric acid it yields picric acid. When heated with
resorcin to 200° C. it gives trioxybenzophenone.
- Salicylic acid is a
white crystalline compound, which can be isolated from the bark of birch
trees. Since it is a valuable substance that can be isolated from
nature, it is called a useful "natural product". Although it was used
historically as an analgesic (pain reliever), today it is commonly used
in ointments and plasters for the removal of warts from the skin.
Acetylsalicylic acid (an ester derivative) is much more commonly used
than salicylic acid itself for pain relief, because the parent compound
can be rather irritating to your stomach linings. Acetylsalicylic acid
is marketed as aspirin.
- Methyl salicylate, like
salicylic acid, is produced by many plants. It was first isolated from
wintergreen leaves, Gaultheria procumbens, and is often called oil of
wintergreen.Methyl salicylate is similar to acetylsalicylic acid in that
it masks one of the acidic hydrogens in salicylic acid. Methyl
salicylate replaces the carboxylic acid hydrogen with a methyl group,
-CH3. The result is a relatively unreactive compound that does not
liberate salicylic acid efficiently in the body. Consequently, methyl
salicylate is not an effective analgesic.
- Salicylic acid is used
to treat acne, warts, dandruff, psoriasis, and similar conditions. In
the treatment of acne, it slows the shedding of skin cells in hair
follicles, so they do not clog the pores and cause pimples. It also has
a keratolytic effect, causing dead cells to slough off. The top layer of
skin is removed, and pores unclogged. In treatments for warts, a
stronger solution is used. This not only softens the wart so it can be
rubbed off, but the irritation stimulates the immune system to attack
the human papillomavirus that causes warts.
- Salicylic acid is used
externally for the removal of corns and similar epidermic thickenings.
It causes some pain, so that a sedative should be added. A common
formula has i 1 parts of the acid, 3 of extract of Indian hemp, and 86
of collodion. There is probably no better remedy for corns. Perspiration
of the feet cannot be attacked locally with more success than by a
powder consisting of salicylic acid, starch and chalk. These drugs are
specific for acute rheumatism.
- Salicylic acid is used
in medicine largely in combination with the alkaline bases, through its
action on the neutral salts of these substances, because of their
superior solubility. Salicylic acid is specifically a remedy for
rheumatism. It is used to best advantage in the acute and sub-acute
forms, but will serve an excellent purpose in the chronic forms of
whatever character. It is now given in the form of its soluble salts.
Relapses are, however, more liable to occur after this agent than after
almost any other remedy.
- According to market
analyst, Mintel, the UK functional food market was worth an estimated
£1.1bn (€1.6bn) in 2005, having grown 143 per cent since the start of
the new millennium.The potential health benefits of herbs and spices
have been consistently researched, with studies of the anti-cancer
effects of turmeric from curcumin, and capsaicin from red chilli pepper
spending significant time in the spotlight recently. The health benefits
of salicylic acid are not in question because the compound is the
metabolite of acetylsaliclylic acid, more commonly known as aspirin.
Recent reports have reported that a daily dose of 75-80 mg of aspirin
may halve the risk of colorectal cancer.
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General
Information
- Phenols
- Salicylic acid
- p-Salicylic acid
- Overview of salicylic
acid
- History of
aspirin
- History and Mechanism
of action of acetylsalicylic acid
Synthesis
- Synthesis of Salicylic
Acid
- Salicylic acid
synthesis and conjugation
- Salicylic Acid
Synthesis
- Complete mechanism for synthesis of salicylic acid
-
- Production of Salicylic
acid precursors
- Biosynthesis of
Salicylic Acid in Potato Plants
- Synthesis and
Characterization of Methacrylic Derivatives of 5-Amino Salicylic
Acid
- Synthesis of Dysprosium
Coordination Polymer of Salicylic Acid
- Synthesis and
evaluation of mutual prodrugs of isoniazid, p-amino salicylic
acid
- Acetylation of
salicylic acid
- Synthesis of
Acetylsalicylic Acid
- Multi-Step Synthesis of
Aspirin
Company
Profiles
- Alta
Laboratories Ltd.
- Bansal Trading
Company
- Jiangsu Winpool Industrial Co., Ltd
- J.M.Loveridge Ltd
- Paragon
Industries
- Qingdao Union Fine
Chemical Co.,Ltd
- Simco Chemicals
Inc.
- SPR Pharma
Consultants
- SRI Consulting
- John W. Zupancic
- Jorg J Goronzy
- Srikumaran (Sri) K. Melethil
- Joseph P. Noel
- Mack Thomas
Ruffin
- Sanford M.
Bolton
Material Safety Data
Sheet
- Salicylic acid
- Fisher
Scientific-Salicylic acid
- Salicylic acid,
99+%
- IPCS-Salicylic
acid
- Salicylic acid
ointment
- Salicylic Acid, Sodium
Salt
Products
- Salicylic acid facial
scrub
- GlyMed Serious
Action Salicylic Acid Cleanser
- Diprosalic
lotion
- Locasalen®
- Nerisalic®
- Salicylic acid in skin
care products
- Vipsogal Ointment
- Clean &
clear
- Salicylic Acid
Peel
- Salicylic acid in
health and beauty
- Acne treatment
products
- Salicylic skin care
products
- List of salicylic acid
products
Applications
- Uses of Ingredients:
Salicylic acid
- Salicylic acid used in
staphylococcal disease
- Salicylic acid used in
hyperkeratotic skin disorders
- Effects of Hypnotic,
Placebo, and Salicylic Acid treaments on Wart regression
- Applications of acidium
salicylicum
- Novel Salicylic acid cream
treats heel Hyperkeratosis without Irritation
- Treatment of Chapped
Lips
- Preparation of
aspirin
Functions and
Properties
- Acclimation of tomato
plants to salinity stress after a salicylic acid pre-treatment
- Salicylic acid and
systemic acquired resistance to pathogen attack
- Partial purification
and characterization of the DCSA
- Antipyretic, analgesic,
anti-inflammatory and cytotoxic effects of four derivatives of salicylic
acid
- Effect of Salicylic
acid on arabidopsis seed germination
- Influence of and
salicylic acid in the enhancement of capsaicin production
- Induction by salicylic
acid of pathogenesis-related proteins and resistance to alfalfa mosaic
virus infection
- Influence of salicylic
acid on the induction of competence for H202 elicitation
- Distribution kinetics
of salicylic acid in the dual perfused rat liver preparation
- Mechanism of peroxidase
actions for salicylic acid
- Coronatine and
salicylic acid
- Purification and
characterization of a soluble salicylic acid-binding protein
- Role of salicylic acid
in regulating cadmium induced oxidative stress
- Hypersensitive cell
death in soybean by salicylic acid
- Temperature-dependent
induction of Salicylic Acid
- Correlation of Free
Salicylic Acid Content
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Patent
- Assay for
salicylate
- Composition for
solubilizing salicylic acid
- Salicylic acid esters
as perfumes
- Hydrous salicylic acid
solutions
- Antidiabetic salicylic
acid derivatives
- Process for making pure
salicylic acid
- Silicone gel containing
salicylic acid
- Skin treatment with
salicylic acid esters
- Process for producing
salicylic esters
- Method for the
alkylation of salicylic acid
Technology
- Determination of the
free salicylic acid concentration in aspirin
- Salicylic acid
degradation from aqueous solutions using pseudomonas fluorescens
- Induction of chalcone
synthase and phenylalanine ammonia-lyase by salicylic acid
- Inhibition of
phenolsulpho transferase by salicylic acid
- Salicylic acid
nitration by means of nitric acid/acetic acid system
- Development of
PMI-5001, a natural salicylate from Gaultheria procumbens
Projects
- Environmental Impact of Aluminum Sulfate and Salicylic
Acid Treated Poultry Litters
- Potato to variety
improvement through gene transfer and virological studies
- Cryotherapy versus
salicylic acid for the treatment of verrucae
- Effects of low
concentrations of salicylic acid on plant growth
- Quantification of the
Acidic Properties of Salicylic Acid
- Kinetics of Aspirin Hydrolysis in Sodium Carbonate
Solution
- The Ability of
Salicylic Acid to Reduce the Damaging Effects of Salt Water Stress
- Chemistry review
projects
Market and
Report
- Rhodia company
market
- Acetylsalicylic Acid
Improves Lipid-Induced Insulin Resistance in Healthy Men
- Fatal reaction to
para-amino-salicylic acid and streptomycin
- Curry favour with
colorectal cancer
- DOE final report
- Effectiveness and
cost-effectiveness of salicylic acid
- A Central Role of
Salicylic Acid in Plant Disease Resistance
- Simultaneous
determination of aspirin and salicylic acid in limited volume plasma
samples by ESI(-)-LC-MS/MS
- Preliminary Report on
the Use of Para-Amino Salicylic Acid in the Treatment of Pulmonary
Tuberculosis
- Quantitative
Reflectance Spot Test for the Determination of Acetylsalicylic
Acid
- Study of salicylic
acid
- EMEA summary
report
- Salicylic acid
specification sheet
- Chemical product
trends: China report
Manufacturers and
Suppliers
- Heterochem (Dist.) Ltd
- Online Catalogs of salicylic acid
- Salicylic acid sell
offers
- Foreign Exporters of salicylic acid
- Indian Exporters salicylic acid
- Salicylic Acid
Manufacturers
- Salicylic Acid CAS 69-72-7 suppliers
- Sell Trade Leads of salicylic acid
- Salicylic acid
sellers
- Selling leads of
salicylic acid
Buyers
- Buy offers of salicylic
acid
- Foreign importers of
salicylic acid
- Indian importers of
salicylic acid
- Salicylic acid buyers
list
Equipment
Suppliers
- Manufacturers of
ceramic heater
- Controller
suppliers
- Graduated cylinder
suppliers
- Disposable pipettes
manufacturers
- Huayin Jinqiancheng Pharmaceutical
Co.,Ltd
- Reflux condenser
suppliers
- Manufacturers of screw
clamps
- Manufacturers of
stirring motor
Safety and Guides
- Side effects of
Carmex
- Side effects of
salicylic acid
- Salicylic acid
preparations for treating warts
- Drug information of
salicylic acid topical
- FAQ's about salicylic
acid and sodium thiosulphate topical
- FAQ's about salicylic
acid
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