- Carboxylic acid
derivatives are compounds with functional groups that can be converted
to carboxylic acids by a simple acidic or basic hydrolysis. They include
esters, amides, nitriles, acid halides, and acid anhydrides.
- Reaction of -OH and
-COOH on same molecule produces a cyclic ester, lactone.
- Esters are named as
alkyl carboxylates.Alkyl from the alcohol, carboxylate from the
carboxylic acid precursor.
- Acyl intermediates
include acyl anions, acyl radicals and acyl cations (synonym: acylium
ions) which are formally derived from oxoacids RkE(=O)l(OH)m (l not
equal to 0) by removal of a hydroxyl cation HO+, a hydroxyl radical HO.
or a hydroxyl anion HO-, respectively, and replacement analogues of such
intermediates.
- The reaction of a
carboxylic acid and an alcohol yields an ester and water is
eliminated.
- A recent synthesis (4)
made S-alkyl thiohydroxamic acids readily available, though in every
case only one isomer, inferred to be the anti form, was isolated.
-
Active N-acyl, derivatives of a-amino
acids are rapidly racemized by acetic anhydride at room
temperature.
- Acyl derivatives of
ara-C4 with long linear saturated fattyacids at the A/4 position of
ara-C exhibited a higher antitumor activity than did ara-C in the mouse
leukemia L1210 system.
- A large number and wide
variety of acyl derivatives of the tylosin-related macrolides
23-demycinosyltylosin (DMT), 23-demycinosyloxytylosin DMOT) and
5-O-mycaminosyltylonolide (OMT) were synthesized and evaluated.
- Analysis of the
kinetics of hydrolytic and other transacylation reactions catalyzed by
a-chymotrypsin yields two kinds of kinetic parameters.
-
Acylation is one of the fundamental reactions in organic
chemistry and can be carried out by wide variety of reagents. Acyl
groups play an important role in the chemistry of biomolecules.
-
Ester enolates which is a derivative of corboxylic acid
derived from alkyl esters of alkanoic acids react with carbony1
compounds in an aldol type reaction forming alkyl
@-hydroxyalkanoates.
-
N-alkylation, N-acylation, and Nhydroxyacylation, type of
organic compound used in each of N-substitution reactions to ultimately
enhance the bioactivity of chitosan.
- The ideal acylating
reagent would be a carboxylic acid, but the acids themselves are
relatively unreactive with nucleophiles. A simple solution to this
inactivity, as noted earlier, was to convert the carboxylic acid to a
more reactive derivative such as an acyl chloride or anhydride.
- Chiral phase HPLC has
mainly been applied to pharmaceutical molecules but Chapter 7 shows how
it can be used to separate enantiomers of monacyl and
diacylglycerols.
- The development of acyl
derivatives was determined by borohydride reduction technique.
- Polybutadiene with a
narrow molecular weight is synthesized by anionic polymerization of
butadiene monomer in cyclohexane at 20 ' C using
n-butyllithium as
Initiator .The amount of urazole and acyl incorporation are determined
by 1H NMR technique. |
General
Information
- Carboxylic Acids and
Derivatives
- Introduction -
Carboxylic Acid Derivatives
- Carboxylic Acid Derivatives and Nitriles
- Nomenclature of
Carboxylic Acid Derivatives
- Carboxylic Acid
Derivatives. Nucleophilic Acyl Substitution
Company
Profile
- China Company
- Company from
China
- Company from
Germany
- Company from
Israel
- US Company from
Texas
- Company from
California
- Company from USA
Consultant
- Consultant from
Minnesota
- Consultant from New
York
- Consultant from
Texas
- Consultant from
UK
- Consultant from
USA
- Consultant from
California
Synthesis
Acyl derivatives
II
Acyl derivatives of Hydroxylamine.
XIII. Configuration and conformation of hydroxamic acid derivatives
containing sulfur
Carboxylic Acid
Derivatives
Enzyme Catalyzation of the Deacylation
of N4-Acyl Derivatives of 1 Arabinofuranosylcytosine in the Mouse Liver
Microsome
Synthesis and
Antimicrobial Evaluation of acyl derivatives of 16-membered macrolide
antibiotics related to tylosin
S-Acyl Derivatives of
Benzothiazole-2-thiol: A Convenient Method for the Synthesis of Amides
and Carbamates
A Quantitative Analysis
of the binding of N-Acyl Derivative of a-aminoacids by a
chymotrypsin
Carboxylic Acid
Derivatives A Substitution Reaction Which Starts With Addition
Enzymatic Reduction of Alkyl and Acyl
Derivatives of Dihydroxyacetone Phosphate by Reduced Pyridine
Nucleotides
Study on the reactions of azo
compounds with acyl halides mediated by Sm/TiCl4
Application
-
Adducts from the Reaction of O,
O'-Diacetyl or O-Acetyl Derivatives of the Carcinogen
4-Hydroxyaminoquinoline 1-Oxide with Furine
- 1-acyl-3-hydroxy-1H-pyrazoles and related
derivatives as useful acylating agents
-
Application of enolates of activated
carboxylic acid derivatives in organic synthesis-novel syntheses of
p-lactones
Esters as Food
Flavourings
Fatty Acyl Derivatives of Glucosamine
1-Phosphate in Escherichia coli and Their Relation to Lipid A
Liquid - Chromatographic DetermInation
of Tocainide in Plasma,with N-Acyl Derivatives of
Tocalnideas
Internal Standards.
On Carboxyl Activation for Peptide Synthesis
Vitamin B12-mediated electrochemical
reactions in the synthesis of natural products
The Synthesis of water
soluble N Acyl chitosan derivatives for characterization as
antibacterial agents
Technology
- Specialized Acylation
Reagents and Techniques
- Amino-Acids,
Acyl-Amino-acids, Dipeptides, Acyl-Dipeptides and Derivatives of these
Compounds by Absorption Spectra
- HPLC of Acyl Lipids
- The development of methods f o r measurement of
Labile Acyl Derivatives
-
Acylation of Polybutadiene Containing
4-Phenyl Urazole
-
Prediction of Acidity Constants of
Thiazolidine-4-carboxylic Acid Derivatives Using Ab Initio and Genetic
Algorithm-Partial Least Squares
|
Project
Patent
- Acyl Derivatives
1
- Acyl Derivatives
2
- Esters on Unsaturated
carboxylic acids
- N-Acyl Derivatives of
aminoalcohols with polycarboxylic acids able to modulate mast cells in
inflammatory processes having neuroimmunogenic origin
- Substituted acyl
derivatives of aminoacids
- Use of Acyl Derivatives
of aminoalcohols in the manufacture of a medicament for practicing
neuroprotective action in neuropathological atates connected with
excitotoxicity
Properties &
Function
-
Antiviral Activities of Acyl
Derivatives of 2,2'-Anhydro-1-f3- D-Arabinofuranosylcytosine and
1-/3-DArabinofuranosylcytosine in Cell Culture
Synthesis and biological activities of
turkesterone 11α-acyl derivatives
3-O-Acyl Derivatives of
Bridged-15-Membered Azalides: Synthesis, Structural Determination and
Antibacterial Activity
N-Acylated and D Enantiomer Derivatives of a
Nonamer Core Peptide of Lactoferricin B Showing Improved Antimicrobial
Activity
Molecular Properties of Acyl Carrier Protein
Derivatives
Report &
Market
-
Dendritic Cell Maturation Induced by
Muramyl Dipeptide (MDP) Derivatives: Monoacylated MDP Confers TLR2/TLR4
Activation
-
Perfluorinated Carboxylic Acids
(PFCAs) and Precursors: A Proposed Action Plan for Assessment and
Management
- Free Radical Acylation Approach of Carbohydrate
Derivatives
Identification of
zomepirac-S-acyl-glucuronide in vitro in incubations with rat
Hepatocytes and in vivo in rat bile
(4-Aminomethyl)phenylguanidine
derivatives as nonpeptidic highly selective inhibitors of human
urokinase
Synthesis and Tautomeric Studies of Enamines
from 1-(n-Hexyl)-3-methyl-2-pyrazolin-5-one
Oxea to Produce Carboxylic Acids in China; Joint Venture with
Shenyang Zhangming Chemical Planned
Suppliers &
buyers
- Suppliers of
Esters
- Suppliers of
Amides
- Suppliers of Acid
Anhydrides
- Suppliers of
Nitriles
- Suppliers of Acid
Halides
- Buyers of Esters
- Buyers of Amides
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