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- The cephalosporins are a class of β-lactam
antibiotics originally derived from the fungus Acremonium, which was
previously known as "Cephalosporium".
- Together with cephamycins they constitute
a subgroup of β-lactam antibiotics called cephems.
- Cephalosporins are indicated for the
prophylaxis and treatment of infections caused by bacteria
susceptible to this particular form of antibiotic.
- First-generation cephalosporins are active
predominantly against Gram-positive bacteria, and
successive generations have increased activity against Gram-negative
bacteria (albeit often with reduced activity against Gram-positive
organisms).
- The classification of cephalosporins into
"generations" is commonly practised, although
the exact categorization of cephalosporins is often imprecise. For
example, the fourth generation of cephalosporins is not recognized
as such, in Japan.
- In Japan, cefaclor is classed as a
first-generation cephalosporin, even though in the United States it
is a second-generation one; and cefbuperazone, cefminox, and
cefotetan are classed as second-generation cephalosporins.
- Cefmetazole and cefoxitin
are classed as third-generation cephems. Flomoxef, latamoxef are in
a new class called oxacephems.
- Most first-generation cephalosporins were
originally spelled "ceph-" in English-
speaking countries. This continues to be the preferred spelling in
the United States and
Australia, while European countries (including the United Kingdom)
have adopted the
International Nonproprietary Names, which are always spelled "cef-".
- Newer first- generation cephalosporins and
all cephalosporins of later generations are spelled "cef-", even in
the United States.
- Some state that, although cephalosporins
can be divided into five or even six generations, the usefulness of
this organization system is of limited clinical relevance.
- Having launched nearly a dozen drugs in
the rs 1,000-crore cephalosporin market, aurobindo pharma has
launched a 4th generation broad spectrum injectible cephalosporin
for the first time in Hyderabad, making it only the second company
in the world after pharma major aventis pharmaceuticals.
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General
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Cephalosporin
-
Cephalosporin Order of Prohibition Questions and Answers
- First Generation Cephalosporins
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Cephalosporins
- Penicillin, Amoxicillin and Cephalosporin
Allergy
- Purpose
- Anti-Infective Chemotherapeutic &
Antibiotic Agents
MSDS
- Ceftazidimide
sodium injection
- Cephalosporin C
zinc salt
- Cefuroxime for
Injection
- Ceftriaxone for
Injection
- Cefotaxime
monosodium salt
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Manufacturing process
- Optimization of
medium constituents for Cephalosporin C production using response
surface methodology and artificial neural networks
- Penicillin and
cephalosporin production: A historical perspective
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Patent
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Market
- News about market
- Cephalosporins
Aren’t Withdrawn From The Market
- Will Lupin’s NDDS
succeed in sliding cephalexin market?
- Parabolic Drugs -
Cephalosporin to drive its Japanese growth story
- Oral Prodrug Enters
Cephalosporin Market
- Parabolic Drugs
gets Japanese nod for Cephalosporin Drugs
Report
- Cephalosporin Order
of Prohibition Goes Into Effect
- FDA Bans
Off-Label Cephalosporin Use in Animals
- Cephalosporin use
restricted in livestock
- FDA Limits an
Antibiotic in Animals to Curb Drug Resistance
- The problem with
cephalosporins
- Citing Drug
Resistance, U.S. Restricts More Antibiotics for Livestock
- FDA to
prohibit certain uses of cephalosporin antibiotics in food animals
- FDA to limit
antibiotics to treat livestock to prevent ‘superbugs’
Study
- Cephalosporin use in treatment
of patients with penicillin
allergies
- Study of the Interaction of Cephalosporin
Class Medicine with Albumin by Fluorescence Enhancement and
Fluorescence
Quenching Theories
- Is There Cross-Reactivity Between
Penicillins and
Cephalosporins?
- Immediate allergic reactions to
cephalosporins: Cross-reactivity
and selective responses
- A study on usage of cephalosporin’s in
hospitalized paediatric patients in rural tertiary care hospital
- Pharmacokinetic Study of an Oral
Cephalosporin, Cefdinir, in Hemodialysis Patients
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