- The adrenal steroid
dehydroepiandrosterone (DHEA) and its sulphate ester, DHEAS are the
most abundant circulating steroid hormones in humans
- DHEA is produced from
cholesterol through two cytochrome P450 enzymes. Cholesterol is
converted to pregnenolone by the enzyme P450 scc (side chain
cleavage); then another enzyme, CYP17A1, converts pregnenolone to
17α-hydroxypregnenolone and then to DHEA
- DHEA concentrations
decrease with age. Low plasma levels of DHEA are correlated with
high mortality rates.
- DHEA and DHEAS are
readily available in the United States, where they are marketed as
over-the-counter dietary supplements
- Dehydroepiandrosterone
(DHEA; brand name Fidelin, Ovomax), also known asandrostenolone or
prasterone (INN), as well as 3β-hydroxyandrost-5-en-17-one or
5-androsten-3β-ol-17-one
- DHEA is legal to sell
in the United States as a dietary supplement
- In the United States,
DHEA or DHEAS have been advertised with claims that they may
be beneficial for a wide variety of ailments
- DHEA is a prohibited
substance under the World Anti-Doping Code of the World Anti-Doping
Agency
- Studies of
dehydroepiandrosterone (DHEA), a sex steroid that converts to
estrogen and testosterone, has shown potential benefit in patients
with depression and adrenal insufficiency and in increasing bone
density and libido in postmenopausal women
- 4,000 companies
reported to promote DHEA products internationally.
- In US it’s a 6
billion$ market
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