- Diazepam is a
"classical" benzodiazepine derivative drug.
- Other classical
benzodiazepines include clonazepam, lorazepam, oxazepam, alprazolam,
nitrazepam, flurazepam, bromazepam and clorazepate.
- Diazepam, first
marketed as Valium by Hoffmann-La Roche.
- Diazepam possesses
anxiolytic, anticonvulsant, sedative, skeletal muscle relaxant and
amnestic properties.
- Diazepam occurs as
solid white or yellow crystals.
- Diazepam can absorb
into plastic, and therefore diazepam solution is not stored in plastic
bottles or syringes etc.
- Diazepam works by
acting on receptors in the brain called GABA receptors. This causes the
release of a neurotransmitter called GABA in the brain.
- Electron-capture gas
chromatography or reversed-phase “high-performance” liquid
chromatography is used for concurrent analysis for diazepam and
nordiazepam in serum.
- The psychomotor
recovery of patients sedated with either midazolam or Diazepam has been
compared using the digit symbol substitution test and the Trieger
test.
- Open-heart operations
with cardiopulmonary bypass, anaesthetized by using primarily the
combination of diazepam with pentazocine.
- Diazepam is mainly used
to treat anxiety, insomnia, and symptoms of acute alcohol or opiate
withdrawal.
- Diazepam is rarely used
for the long-term treatment of epilepsy.
Diazepam is used as a short
term sedative and anxiolytic for cats and dogs.
- Diazepam is also used
as a muscle relaxant for horses.
Diazepam increases the central
depressive effects of alcohol, other hypnotics/sedatives (e.g.
barbiturates), narcotics, and other muscle relaxants.
- Diazepam-binding
inhibitor(DBI) mediates the postprandial rise in plasma
cholecystokinin-releasing peptide(CCK) levels.
- High-dose diazepam
reduces prime-induced activation of alcohol-related words(ALC) concepts
in problem drinkers.
- The heat effect
associated with the binding of diazepam to human serum albumin has been
measured using flow microcalorimetry technique.
- The effect of diazepam
on respiration has been investigated by the modification of the
rebreathing CO2-challenge technique.
- The drug diazepam is
measured by gas-liquid chromatography technique, with use of an electron
capture detector.
- HPLC method is
developed for identification and simultaneous determination of diazepam
and preservatives (benzyl alcohol and benzoic acid / sodium
benzoate).
- An estimated 38,000
addicts of substances such as heroin using benzodiazepines in Scotland,
increasing the risk of death.
- Across the UK have
struggled for years to come off benzodiazepines after being legally
prescribed them
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General
Information
- Diazepam - Drug
information
- About Diazepam
- Valium
- Diazepam
Company Profiles
& Consultant
- Company from
India
- Company from New
Jersey
- Company from
Virginia
- Consultant from
Illinois
- Consultant from
Italy
- Consultant from
Minnesota
Synthesis &
Process
- Analysis for Diazepam
and Nordiazepam by Electron-Capture Gas Chromatography and by Liquid
Chromatography
- Evaluation of Antidotes
for Poisoning by Organophosphorus Pesticides - Diazepam
- Molecularly imprinted
polymer for solid-phase extraction of diazepam and its metabolites from
hair samples
- A randomized comparison
of midazolam and diazepam injectable emulsion in cataract surgery
- Supercritical fluid
extraction of diazepam from whole blood using fillers
- Simultaneous
determination of diazepam and preservatives in HPMC hydrogel by
HPLC
- Diazepam (Valium)
Synthesis
Application
- Diazepam-binding
inhibitor mediates feedback regulation of pancreatic secretion and
postprandial release of cholecystokinin
- Diazepam
dose-dependently increases or decreases implicit priming of alcohol
asscociation in problem drinkers
- Liquid-Chromatographic
Assay of Diazepam and Its Major Metabolites in Serum, and Application to
Pharmacokinetic Study of High Doses of Diazepam in Schizophrenics
- Bicuculline,
pentobarbital and diazepam modulate spontaneous GABAA channels in rat
hippocampal neurons
- Comparison of the
influence of diazepam and new benzodiazepine derivative on the behaviour
of rabbits under spontaneous conditions
The use of
Chirascan to study the competitive binding of diazepam and ibuprofen to
human serum albumin (HSA)
Technology
- The pH Dependence of
the Thermodynamics of the Interaction of Diazepam with Human Serum
Albumin
- The effect of
Diazepam on the respiratory response to carbondioxide
- Micromethod for
Determination of Diazepam by Electron-Capture Gas-Liquid
Chromatography
- A Simple flow injection
spectrophotometric procedure for the determination of diazepam in
pharmaceutical formulation
- Diazepam-Pentazocine
anaesthesia for cardiovascular surgery
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Material Safety Data
Sheet
- Diazepam
- Diazepam Elixir
- Diazepam Injection
- Pamlin Injection
- Benzphetamine Hydrochloride Tablets 50 mg
Product
- Apaurin
- Apo-Diazepam
- Aspen Diazepam Injection
10 mg/2 mL
- Diazepam Tablets
DiaJect Auto-injector
Patent
- Buccal, Polar and non-polar spray containing
diazepam
- Delivery of diazepam through an inhalation
route
- Diazepam enzyme conjugates
- Pre-filled injection a barrel wherein a liquid
diazepam formulation is accommodated
- Preparation of diazepam
Function
- Effects of vitamin C on
ketamine-diazepam anesthesia in dogs
- Effects of Diazepam on
Human Pain Tolerance and Pain Sensitivity
- Influence of ethanol on
the myorelaxant effect of diazepam in rat
- Sedative effect of oral
diazepam and chloral hydrate in the dental treatment of
children
- Brain targeted
transcranial route of drug delivery of diazepam
Report
- Case report: A
fugue-like state associated with diazepam use
- Intravenous Injection
of Diazepam to Cubital Vein Can be Complicated by Accidental
Intra-Arterial Penetration and Gangrene
- Diazepam-Ketamine
anaesthesia for the surgical management of electric burns in bonnet
macaque monkeys - Report of two cases
- Diazepam in severe
tetanus treatment - case report
- Use of Diazepam for
transportations of Himalayan black bear
- Valium nation investigation by health correspondent judith
duffy
Guidelines
- Rectal Diazepam -
Instructions for Home Use
South Gloucestershire Drug Action Team Guidelines on good
practice in prescribing Benzodiazepines to Drug Users in General
Practice
Protocol for the
administration of rectal diazepam for named patients by healthcare
staff in learning disabilities units
Benzodiazepine and
Non-Benzodiazepine Guidelines for General Practice
Pediatric dosing
guidelines for nerve agents
Suppliers
- Suppliers of
Diazepam
- Selling leads of
Diazepam
- Exporters of
Diazepam
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