Fluconazole                               General, Process, Functions, Company Profiles, Patent, Applications, Material Safety Data Sheet, Report                                             Primary Information Services                                                     Home. Ordering Information. Contact

• Fluconazole is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections.
• It appears as a white crystalline powder, and it is very slightly soluble in water and it is also soluble in alcohol.
• Fluconazole is a drug belonging to the class of anti fungals called triazoles.
• Fluconazole is well absorbed orally with or without food.
• It is used for treating various fungal infections in different parts of the body, including yeast infections of the vagina, mouth, throat, esophagus , abdomen , lungs.
• Fluconazole may increase the concentration of these drugs and enhance their effect: Warfarin , Antidiabetic sulphonylurea medication (tolbutamide, glibenclamide, gliclazide, glipizide., Phenytoin, Theophylline, Ciclosporin, Celecoxib.
• Fluconazole is also used to prevent yeast infections in patients who are likely to become infected because they are being treated with chemotherapy or radiation therapy before a bone marrow transplant.
• Fluconazole is also sometimes used to prevent fungal infections in people who are likely to become infected because they have human immunodeficiency virus (HIV) or cancer or have had a transplant operation .
• Fluconazole (Diflucan) is a synthetic antifungal agent which can be used for the treatment of a variety of Candida albicans infections.
• Fluconazole has also been effective in the treatment of fungal septicemia in the neonatal population.
• Fluconazole is a widely used bis-triazole antifungal agent. As with other triazoles, it has five-membered ring structures containing three nitrogen atoms. It is marketed as Diflucan® by Pfizer Pharmaceuticals. Both oral and intravenous formulations of fluconazole are available.
• As with all azole antifungal agents, fluconazole works principally by inhibition of cytochrome P450 14a-demethylase.
• Fluconazole is also sometimes used to treat serious fungal infections that begin in the lungs and can spread through the body and fungal infections of the eye, prostate (a male reproductive organ), skin and nails.  

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• Fluconazole - Diflucan

Process

• Prevalence & susceptibility to fluconazole of Candida species causing vulvovaginitis
• Peptone glucose fluconazole agar, a selective medium for rapid and enhanced isolation of Aspergillus fumigatus from aqueous suspensions and sputum seeded with Candida albicans
• Enhanced Production of Farnesol by Candida albicans Treated with Four Azoles
• In vitro Inhibition Potencies of Fluconazole, Itraconazole and Voriconazole towards CYP2B6-
  mediated Cyclophosphamide Activation
• Production of a human recombinant antibody against serotype a Candida albicans

Functions

• Intracellular Activity of Voriconazole, Fluconazole, and Itraconazole Against Candida albicans in Human Monocytes
  With and Without Activation by GM-CSF and TNF-a
• The Effect of Fluconazole on  Cyclophosphamide metabolism in Children
• Fluconazole prophylaxis against fungal colonization and infection in preterm infants
• The effects of fluconazole and cytokines on human mononuclear cells
• The presence of fluconazole-resistant Candida dubliniensis strains among Candida albicans isolates from immunocompromised or otherwise debilitated HIV-negative Turkish patients
• Synergistic Antifungal Activities of Bafilomycin A1, Fluconazole, and the Pneumocandin MK-0991/Caspofungin Acetate (L-743,873) with Calcineurin Inhibitors FK506 and L-685,818 against Cryptococcus neoformans
• Evaluation of fluconazole resistance mechanisms in Candida albicans clinical isolates from HIV-infected patients in Brazil

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