- Glibenclamide, also known as
glyburide, is an anti-diabetic drug in a class of medications known as
sulfonylureas, used in the treatment of type II diabetes.
- Glyburide is in a class of drugs
called sulfonylureas.
- It is used to help control blood
sugar levels.
- Treatment with glyburide may
increase the risk of death from cardiovascular disease compared to
treatment of diabetes with diet alone or diet plus insulin.
- The drug works by inhibiting
ATP-sensitive potassium channels in pancreatic beta cells.
- This inhibition causes cell
membrane depolarization, opening of voltage-dependent calcium channels,
thus triggering an increase in intracellular calcium into the beta cell
which stimulates insulin release.
- Inhibition of ATP-sensitive K
channels by an increase in cytosolic ATP4 or a decrease in Mg ADP
and the resultant depolarization are essentially involved in the
physiological mechanisms that lead to insulin secretion from
pancreatic-cells.
- To identify among women with
gestational diabetes mellitus the patient characteristics that
predict treatment failure with glyburide.
- Glyburide was more likely to fail
in women diagnosed earlier in pregnancy, of older age and multiparity,
and with higher fasting glucoses, suggesting that earlier glucose
intolerance and a reduced capacity to respond to an insulin secretagogue
may distinguish this group.
- The whole-cell patch-clamp
technique was used in adult mouse ventricular myocytes at 22°C to study
the transient outward current and its sensitivity to the antimycotics
miconazole and clotrimazole, as well as to glybenclamide.
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Introduction
- Glibenclamide
- Glibenclamide
- Glyburide
Process
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Differential Effects of Glucose and
Glyburide on Energetics and Na+ Levels of HC9 Cells
Preparation of nano crystals of
glyburide by high energy controlled salting out process and their
characterization
Rosiglitazone, But Not Glyburide,
Reduces Circulating Proinsulin and the Proinsulin
Effects Of The Sulfonylurea Glyburide
On Catalase Activities in Streptozotocin-Induced Diabetic Rat
Muscle
Synthesis of benzoic acid and
its analoguous labeling precursor
Application
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Effect of glyburide and w3 fatty acid
dietary supplements on glucose and lipid metabolism in patients with
non- insulin dependent diabetes mellitus
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Effects of the Combination of a
Dipeptidyl Peptidase IV Inhibitor and an Insulin Secretagogue on Glucose
and Insulin Levels in Mice and Rats
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Mesenteric Arterial Relaxation to
Calcitonin Gene-Related Peptide Is Increased During Pregnancy and by Sex
Steroid Hormones1
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A New Generation of
Hypoglycemics
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Stimulation of Bile Duct Epithelial
Secretion by Glybenclamide in Normal and Cholestatic Rat Liver
Msds
Safety data
for glyburide
Glyburide Msds
Glybenclamide
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Report
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ATP-binding Cassette Transporter
A1 Functions as a Cholesterol Efflux Regulatory Protein
Effect of indomethacin on electrical
field stimulation-induced contractions of isolated transverse and
longitudinal rat gastric fundus strips
Glucose-dependent, mediated ATP efflux
from Saccharomyces cerevisiae
Separately Inherited Defects in
Insulin Exocytosis and -Cell Glucose Metabolism Contribute to Type 2
Diabetes
Predictors of Glyburide Failure in the
Treatment of Gestational Diabetes
Role of K+ATP channels in coronary
vasodilation during exercise
Patent &
Technology
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Glyburide composition
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Synergistic effect of glyburide and
milrinone
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Composition and method for treating
diabetes
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Spray-dried lactose formulation of
micronized glyburide
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Pharmaceutical compositions for oral
use, containing, in combination, met formin and glyclazide
Suppression of Transient Outward
Potassium Currents in Mouse Ventricular Myocytes by Imidazole
Antimycotics and by Glybenclamide
31P and 23Na NMR Spectroscopy
Demonstrate Glyburide Effects on Bioenergetics and Na+ Transport in
Pancreatic Beta-HC9 Cells
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