- Nalidixic acid is the
basis for quinolone antibiotics.
- Nalidixic acid occurs
as white to light yellow crystals or crystalline powder and it is
odorless.
- Nalidixic acid is
sparingly soluble in chloroform and in N,N-dimethyl formamide, very
slightly soluble in ethanol and in diethyl ether and practically
insoluble in water.
- Nalidixic acid, which
was introduced into clinical use in 1967, was the first member of the
quinolone group of antimicrobials. It is a specific inhibitor of
bacterial DNA gyrase.
- Nalidixic acid is
bactericidal against Enterobacteriaceae, including many strains of
Shigella spp.
- Nalidixic acid has been
used to interrupt DNA synthesis in exponentially growing cultures of E.
coli.
- The antibiotic,
nalidixic acid (NAL), is a relatively specific inhibitor of DNA
synthesis in Bacillus subtilis, leading to "unbalanced growth" in which
cells continue to elongate and to synthesize RNA and protein.
- The kinetics of loss of
the chloroplast-associated DNA and the sensitivity of chloroplast
replication to ultraviolet light was followed during treatment with
nalidixic acid.
- Nalidixic acid is
effective against both gram-positive and gram-negative bacteria. In
lower concentrations, it acts in a bacteriostatic manner; that is, it
inhibits growth and reproduction. In higher concentrations, it is
bactericidal, meaning that it kills bacteria instead of merely
inhibiting their growth.
- Nalidixic acid rapidly
and specifically inhibits DNA synthesis in E. coli. Upon removal of the
acid, DNA synthesis resumes rapidly and proceeds at a higher-than-normal
rate.
- Nalidixic and oxolinic
acids inhibit DNA gyrase activity and induce formation of a relaxation
complex analogue.
- Nalidixic acid is
especially used in treating urinary tract infections, caused, for
example, by Escherichia coli, Proteus, Shigella, Enterobacter, and
Klebsiella.
- Nalidixic acid is also
a tool in studies as a regulation of bacterial division and it is
selectively and reversibly blocks DNA replication in susceptible
bacteria.
- Nalidixic acid and
related antibiotics inhibit a subunit of DNA gyrase and induce formation
of relaxation complex analogue.
- The effect of nalidixic
acid on pulse-labeled protein patterns was analyzed by sodium dodecyl
sulfate-polyacrylamide slab gel electrophoresis.
- Nalidixic acid also
inhibits the nicking dosing activity on the subunit of DNA gyrase that
release the positive binding stress on on the supercoiled DNA.
- Nalidixic acid an
antibacterial drug with a narrow spectrum is used mainly for urinary and
intestinal infections.
- Nalidixic acid
resistance has been used as a selective marker for studies of
pathogen-inoculated
fruits and vegetables.
- In past years, the use
of the nalidixic acid screening test was recommended by the Clinical and
Laboratory Standards Institute for the detection of invasive Salmonella
isolates.
- Nalidixic acid was
the earliest introduced in India about two decades back followed by
Norfloxacin in 1988 and later Ciprofloxacin was introduced for clinical
use.
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General
- About nalidixic
acid
- Information about
nalidixic acid
- Nalidixic acid
information
- General information
about nalidixic acid
Process
- Action of
Nalidixic Acid on Chloroplast Replication in Euglena
gracilis
- Bactericidal
Action of Nalidixic Acid on Bacillus subtilis
- Mechanism of Action of
Nalidixic Acid on Escherichia coli
- Mechanism of action of
nalidixic acid: Purification of Escherichia coli nalA gene product and
its relationship to DNA gyrase and a novel nicking-closing enzyme
- Nalidixic Acid-Induced
Protein Alterations in Escherichia coli
- Synchronous
Reinitiation of Chromosome Replication in E. coli B/r after Nalidixic
Acid Treatment
Company
Profiles
- Company from
California
- Company from
Hungary
- Company from
India
- Another company from
India
- Company from
Japan
- Company from
Maharashtra
Consultants &
Project
- Consultant from
Florida
- Consultant from
India
- Another consultant from
India
- Consultant from
USA
- Consultant from
Mumbai
- Consultant from
Woerden
- The carcinogenetic
potency project on nalidixic acid
Patent &
Technology
- 1,2-Ethanediamine salts
of nalidixic acid
- Mechanism of inhibition
of DNA gyrase by analogues of nalidixic acid: The target of the drugs is
DNA
- A genomic approach to
gene fusion technology
- Quinolones and
False-Positive Urine Screening for Opiates by Immunoassay
Technology
- Use of a MAMA-PCR
Method to detect gyrA Mutations in Nalidixic Acid Resistant Clinical
Isolates of Escherichia coli
Functions
- Mechanism of phage Mu-I
integration: Nalidixic acid treatment causes clustering of Mu-1-induced
mutations near replication origin
- The rheological
effects of nalidixic acid on poly caprolactone
- Effect of
Nalidixic Acid on PBS2 Bacteriophage Infection of Bacillus
subtilis
- Pharmacokinetics of
nalidixic acid in the dog
- Photochemical Reaction
of Nalidixic Acid in Methanol
- Nalidixic Acid and
Macromolecular Metabolism in Tetrahymena pyriformis: Effects on Protein
Synthesis
Manufacturer's -
Product information (msds)
- Nalidixic acid
- Nalidixic acid material safety data sheet
- Nalidixic acid MSDS
- Material safety data sheet for nalidixic
acid
- Safety
data for nalidixic acid
- MSDS for nalidixic acid
- MSDS - Canada company
|
Turnkey Project Offer
-
Company in Maharastra
- Company in Canada
- Company
in Mumbai
- Company in Gujarat
Properties
- Studies on
molecular interactions between nalidixic acid and
liposomes
- Effect of Nalidixic
Acid on DNA Replication by Toluene-Treated
Escherichia coli
- Novobiocin,
Nalidixic Acid, Etoposide, and 4'-(9-Acridinylamino)
methanesulfon-manisidide Effects on G2 and Mitotic Chinese Hamster Ovary
Cell Progression
- Some Properties of
Subunits of DNA Gyrase from Pseudomonas aeruginosa PAO1 and Its
Nalidixic Acid-Resistant Mutant
Applications
- Predictive efficacy of nalidixic acid resistance
as a marker of fluoroquinolone resistance in Salmonella enterica var
Typhi
- Nalidixic Acid Resistance Increases Sensitivity
of Escherichia coli O157:H7 to Ionizing Radiation in Solution and on
Green Leaf Lettuce
- Specific inhibition of chloroplast replication
in euglen a gracilis by nalidixic acid
- Nalidixic Acid for Enrichment of Auxotrophs in
Cultures of Salmonella typhimurium
Product
- Nalidixic acid ≥98%
- BBL Todd Hewitt Broth with gentamicin and
nalidixic acid
- Nalidixic acid
- Nalidixic Acid G.P.
- Product of Nalidixic acid
- Nalidixic acid BioChemika, ≥99.0% (T)
- Ruz- Nalidixic acidŽ 500 MG TAB
- Nalidixic acid product
Report
- Emergence of nalidixic acid resistance in
shigella sonnei isolated from patients having acute diarrheal disease:
Report from eastern province of saudi arabia
- New Quinolone Resistance Phenomenon in
Salmonella enterica: Nalidixic Acid-Susceptible Isolates with
Reduced
Fluoroquinolone Susceptibility
- An outbreak of nalidixic acid resistant
salmonella enterica serovar enteritidis at a nursery school in
kitakyushu city, japan
- Nalidixic acid resistant salmonella enterica
serovar typhi with decreased susceptibility to ciprofloxacin caused
treatment failure: a report from bangladesh
- Nalidixic acid
- Epidemiological Study of Resistance to Nalidixic
Acid and Other Antibiotics in Clinical Yersinia enterocolitica O:3
Isolates
- A Comparative Clinical Trial Between Piromidic
Acid And Nalidixic Acid
- Another 10thYear Anniversary:
A NARMS
Update
Toxicity
- Toxicological
Examinations of Oxolinic Acid and Nalidixic Acidin Ye1lowtail
- Toxicity of
Nalidixic Acid on Candida albicans, Saccharomyces cerevisiae, and
Kluyveromyces lactis
Market Information
- Prices, sellers,Buyer
- Sourcing company
- Supplier
- Selling leads
of nalidixic acid
- India Information
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