- Tolbutamide is a first
generation potassium channel blocker, sulfonylurea oral hypoglycemic
drug sold under the brand name Orinase.
- Orinase was developed
by Upjohn Co. at a time when the primary medical treatment for diabetes
was insulin injections.
- Tolbutamide stimulates
the secretion of insulin by the pancreas. Since the pancreas must
synthesize insulin in order for this drug to work, it is not effective
in the management of type I diabetes.
- Tolbutamide,
tolazamide, or chlorpropamide may be used in combination with insulin
when sulfonylurea monotherapy fails to reduce symptoms and/or blood
glucose levels.
- Orinase diagnostic
Sterile Powder contains tolbutamide sodium which is a white to
off-white, practically odorless, crystalline powder, having a slightly
bitter taste. It is freely soluble in water, soluble in alcohol and in
chloroform, very slightly soluble in ether.
- The chemical name for
tolbutamide sodium is 1-Butyl-3-(p-tolylsulfonyl) urea monosodium salt
C12H17N2NaO3S.
- Sulfonylureas lower
blood glucose in patients with type 2 diabetes by directly stimulating
the acute release of insulin from functioning beta cells of pancreatic
islet tissue by an unknown process that involves a sulfonylurea receptor
(receptor 1) on the beta cell.
- Sulfonylureas inhibit
the ATP-potassium channels on the beta cell membrane and potassium
efflux, which results in depolarization and calcium influx,
calcium-calmodulin binding, kinase activation, and release of
insulin-containing granules by exocytosis, an effect similar to that of
glucose.
- Grazing incidence
diffraction (GID) is a technique not yet being used in the field of
pharmaceutical physics widely. However, GID is a very potential
alternative to the other surface sensitive techniques, e.g. various
spectroscopic methods, used in the pharmaceutical materials
analysis.
- Tolbutamide is an
antidiabetic medication which is used in those patients with adult
maturity onset or non-insulin dependent diabetes (NIDDM). It works by
lowering blood sugar levels by stimulating the production and release of
insulin from the pancreas. It also promotes the movement of sugar from
the blood into the cells in the body which need it.
- Tolbutamide may alter the blood thinning ability
of warfarin and the other coumarins.
- The heritage of Orinase
has had a lasting effect on medicine and the pharmaceutical industry.
Patients today are still diagnosed with prediabetes, many of them
managing to stave off the onset of diabetes through dietary and
lifestyle changes.
- Orinase was one of a
number of drugs developed during the 1950's and 1960's for a variety of
conditions first to treat symptomatic diseases and later to treat
asymptomatic conditions that put the patient at risk of developing
symptomatic disease.
- Its use and marketing
played a definitive, though not solely sufficient, role in establishing
the condition of prediabetes as a legitimate diagnosable
condition.
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General
Information
- Tolbutamide
- About
Tolbutamide
- Sk-tolbutamide -
General Information
- Host-Guest Chemistry of
Tolbutamide
- Tolbutamide for
health
- Tolbutamidec
- Graphical
Representation for Tolbutamide
- Tolbutamide as
Medicine
Consultant
- Consultant from
London.
- Experts in Tolbutamide
- Consultant from
Singapore
- Consultant from
Egypt
Process
-
Synthesis of F-18 Labeled Tolbutamide
as Beta-Cells Imaging Agent
Influence of antioxidant (L- ascorbic
acid) on tolbutamide induced hypoglycaemia / antihyperglycaemia in
normal and diabetic rats Characterization of
Human Liver Microsomal Tolbutamide Hydroxylation from a CYP2C9 *2/*2
Individual
Tolbutamide stimulates
exocytosis of glucagon by inhibition of a mitochondrial-like
ATP-sensitive K + (KATP) conductance in rat pancreatic A-cells
Tolbutamide and diazoxide modulate
phospholipase C-linked Ca21 signaling and insulin secretion in b-cells
Application
-
Tolbutamide and Diazoxide Influence
Insulin Secretion by Changing the Concentration but Not the Action of
Cytoplasmic Ca2 + in
b- Cells
Insulin Response to Glucagon with or
without Tolbutamide in Normal and Diabetic Subjects Isolation and
Properties of Secretory Granules from rat islets of langerhans
Pancreatic
Harmone
The stimulatory action of tolbutamide
on Ca21-dependent
exocytosis in pancreatic b cells is mediated by a 65-kDa mdr-like
P-glycoprotein Enzymatic Activity of
Pancreatic Islets and Acini in normal and in Tolbutamide-Treated
Rats
The Use of Tolbutamide-Induced
Hypoglycemia to Examine the Intraislet Role of Insulin in Mediating
Glucagon Release in Normal Humans
Technology
1H-NMR:
Ultimate Tools for the Investigation of Tolbutamide :b -Cyclodextrin and
Tolbutamide : Hydroxypropyl-b - Cyclodextrin Complexes
Glucose and Tolbutamide Induce
Apoptosis in Pancreatic b-Cells
Serum tolbutamide and chlorpropamide
concentrations in patients with diabetes mellitus
Grazing Incidence XRay Diffraction
Studies of Pharmaceutical Tablets
Quantitation of Crystalline Polymorphs
of Tolbutamide in a Model Formulation Using 13C CPMAS NMR
Spectroscopy |
Material Safety Data Sheet
& Product
- Tolbutamide
- Safety data for
tolbutamide
- 4-hydroxy
Tolbutamide
- 1-Butyl-3-(p-tolylsulfonyl)urea
- Orinase
- Orinase Diagnostic
-
Patent
- Cerium Containing
Hypoglycemic agents
- Method for treating
diabetes
- Methods for treating
neural cell swelling
- Use of Sulphonylurea in
the treatment of oedema
- Use of Tolbutamide in
the treatment of acne
Project
- Enzyme activity
analysis of CYP2C18 with exon 5 skipped
- ESRD Outpatient
Medications Project
- The Carcinigenic
Potency project - Tolbutamide
- Simulation of
anti-diabetic drug action in vivo
Functions
-
Cell specificity of the cytoplasmic
Ca
2C
response to
tolbutamide is impaired in b-cells from hyperglycemic mice The effects of
tolbutamide on the myocardium in experimental diabetes
A Minimum of Fuel Is Necessary for
Tolbutamide to Mimic the Effects of Glucose on Electrical Activity in
Pancreatic b-Cells
Different Effects of Tolbutamide and
Diazoxide in
a-, b-, and d-Cells Within Intact Islets of Langerhans Effects of Tolbutamide
Upon Gastric Secretion and Emptying
Effect of Insulin and Tolbutamide on
Growth Rate, Blood Glucose and Body Composition of Lambs
Effects of Tolbutamide
on Vascular ATP- Sensitive Potassium Channels in Human
Report
-
Prolonged elimination of tolbutamide
in a premature newborn with hyperinsulinaemic hypoglycaemia
Acute Insulin Responses to Calcium and
Tolbutamide Do Not Differentiate Focal from Diffuse Congenital
Hyperinsulinism
Establishment of a transgenic cell
line stably expressing human cytochrome P450 2C18 and identification of
a CYP2C18 clone with exon 5 missing Peritoneal Dialysis
Alters Tolbutamide Pharmacokinetics in Rats with Experimental Acute
Renal Failure
Transepithelial
Permeation of Tolbutamide Across the Human Intestinal Cell
line
Company Profile
& Suppliers
- Company from
India
- Company from USA
- Supplier from
Italy
- Tolbutamide Indian
Suppliers Directory
- Supplier from
India
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