- Monoclonal
antibodies(mAbs) are just like antibodies except they are artificially
produced from the clones of a single cell.
- Monoclonal
antibodies are made by multiple, identical copies (i.e. clones) of a
cell called a hybridoma.
- Monoclonal
antibodies are produced by fusing single antibody-forming cells to tumor
cells grown in culture. The resulting cell is called a
hybridoma.
- Monoclonal
antibodies are created with cell fusion technology and cell culture
technology .
- Once a monoclonal
antibody is made, it can be used as a specific probe to track down and
purify the specific protein that induced its formation.
- Monoclonal
antibodies can be used to classify strains of a single pathogen, e.g.
Neisseria gonorrhoeae can be typed using monoclonal
antibodies.
- Monoclonal
antibodies are widely used as diagnostic and research reagents. Their
introduction into human therapy has been much slower.
- Monoclonal
antibodies (MABs or MOABs) work on cancer cells in the same way natural
antibodies work, by identifying and binding to the target
cells.
- The market for
therapeutic monoclonal antibodies (mAbs) is one of the most dynamic
sectors within the pharmaceutical industry.
- The current global
clinical antibody pipeline, which comprises 132 products in development
and is dominated by humanized (42%) and fully human (28%)mAbs, is poised
to deliver as many as 16 new products between 2004 and 2008.
- As a result of
growth in existing markets for mAb therapeutics,and the opening of new
ones, the global market is projected to increase to US $16.7 billion in
2008.
- The mAbs market is
expected to almost triple in value over the next six years from $10.3
billion in 2004 to $30.3 billion. Oncology products will continue to
dominate the market. However, sales of arthritis, immune and
inflammatory disorders (AIID) products are forecast to grow strongly and
account for 40.1% of the market by 2010.
- Chimeric mAbs were
the undisputed leaders,with 43% growth and US $3.8 billion in sales,
followed by humanized
mAbs with more than US $1.4 billion in sales
and growth of 29%.
- The development
focus of the industry is moving away from murine and chimeric
antibodies, to humanized and, in particular, fully human technologies. A
wave of fully human products are expected to launch from 2007 onwards,
accounting for 12 of the 20 launches between 2007 and 2010.
- Roche and
Genentech dominate the mAbs market, with a combined market share of
44.9% in 2004, although this is forecast to slip to 35.7% in 2010.
- Next generation
antibodies are forecast to drive the market towards the $30 billion mark
by 2011 due to a high level of innovation in early-stage discovery and
several potential nichebusters set to launch in the next 5
years.
- Applications of
Monoclonal Antibodies include: Identification of Cell Surface Markers ,
Detection Assays , Purification Techniques , Gene Identification ,
Disease Therapy , Use in Applied Chemistry
|
General
Introduction
- Monoclonal
antibodies - Discovery
- Monoclonal Antibodies
- Monoclonal
Antibodies - FAQ
- Monoclonal
Antibodies - Q&A
- Monoclonal
Antibody Form and Function
- Monoclonal
Antibodies - Procedure
Technology
- Advances in
Monoclonal Antibody Technology
- Antibody
Technology Developments
- Monoclonal
Antibody Technology Developed by China
- Monoclonal
antibody technology - Definition and Scoper
- Cambridge Antibody
Technology
- Monoclonal
Antibody Technology
- New Antibody
Production Technology
- ECVAM Workshop
- Tech
Transfer
- Monoclonal
Antibody Technology - The Basics
Technology
Offers
- EMBL Technology
Transfer
- Mabtech AB
Technology Offer
- Cambridge Antibody
Technology Group plc Offer
- Innovative
technology for production of monoclonal antibodies
- MorphoSys
Technology Offering
- Stem Cell
Isolation - Technology Offer
- Rapid separation
of free target cells by the use of magnetic beads
- Technology Offers
from Israel
- Method for
Separating Viable (Eurcaryotic) Cells from Cell Suspensions
- Vaccinex, Inc.
Technology Offer
Production and
Guidelines
- Guidelines for the
Production of Polyclonal and Monoclonal Antibodies
- Regulatable
systemic production of monoclonal antibodies
- Guidelines on
Monoclonal Antibody Production
- In Vivo Monoclonal
Antibody Production Guidelines
- Production of
murine monoclonal anti-B
- Production and
Characterization of Monoclonal Antibodies against Vegetative Cells of
Bacillus cereus
- Production of
Monoclonal Antibody Specific for Human Hemoglobin
- Large scale
production of monoclonal antibodies
- Monoclonal
Antibody Production
Market
- Price
List
- Strategies for
Monoclonal Antibody Therapy 2004
- Antibodies
2005
- Monoclonal
Antibody Successes in the Clinic
- The Monoclonal
Antibody Story Continues
- Economic impact
of applications of monoclonal antibodies to medicine and
biology
- The Future of
Monoclonal Antibody Therapeutics
- Monoclonal
antibodies market
Projects
- Manufacturing Unit
for Monoclonal Antibodies
- Monoclonal
Antibodies in Fish and Shellfish Health Management in India
- Research
Project
- Competitive
Enzyme-Linked Immunosorbent Assay
- Role of Antibody
in Protection Against Listeria monocytogenes
- Environmental
Management Science Program
- Modified lysozyme
as a potential alternative to
antibiotics in animal
production
- Prevalence of
Fluorescent Monoclonal Antibody
- Monoclonal
Antibody Production Services
- Monoclonal
Antibody Development Services
|
Company Profiles
- Elusys
Therapeutics, Inc
- Companies Load Up
On Magic Bullets
- Epitomics Inc.,
- Leinco
Technologies
- Medarex
- NeoClone
- Company
and Institute Resources Providing New
Technologies
- Monoclonal
Antibody Suppliers
- Ablynx
- Biocytex
- Biodesign
International
- Cambridge Antibody
Technology
- Biolex,
Inc.
- Cell Sciences
- Genmab
- Glycart
Biotechnology
- CuraGen
Corp.
- ImClone Systems
- Oxford
Biotechnology Ltd.
- Progenics
Pharmaceuticals Ltd.
- Symphogen
- TNB Laboratories
Inc.
- TolerRx
Applications
- High-Affinity
Monoclonal Antibodies for Aflatoxins and Their Application to
Solid-Phase Immunoassays
- Alternatives to
Monoclonal Antibody Production
- Clinical
Applications of Monoclonal Antibodies
- Clinical
Laboratory Applications of Monoclonal Antibodies
- Monoclonal
Antibodies and Therapies
- Origins of
Monoclonal antibody therapy
- Monoclonal
antibody-based immunodot test for epizootic ulcerative syndrome
pathogen, Aphanomyces invadans
- Therapeutic
Applications
- Monoclonal
Antibodies Uses
- Application of the
Monoclonal Antibodies
- Application of
Monoclonal Antibodies to Vibrio cholerae 0139 Synonym Bengal
- Preparation and
Primary Application of Monoclonal Antibodies
- Production and
Application of Monoclonal
Antibodies to Human Selenoprotein
P
- Monoclonal
Antibodies Used as Reagents in Drug Manufacturing
- Spectrum of
Applications of Monoclonal Antibody Therapy
- Monoclonal
Antibodies for the Detection of Integrins
- Immunogenicity of
Monoclonal Antibody Products
- Monoclonal
Antibodies for Research and Clinical Use
- Monoclonal
Antibody Therapy
Reports
- Report of the
Committee on Methods of Producing Monoclonal Antibodies
- Monoclonal
Antibody-Based Therapies
- The Cochrane Renal
Group
- Elmar Schnee on
the Pharmaceuticals business sector
- Millipore - Annual
Report
- Short
Report
- ImmunoafRnity
Purification of S-Antigen Using Monoclonal Antibodies to Different
Antigenic Sites
Consultants
- Professor
Akabani's
- Experts
- BioAnalab
- Consultant
- D-Gen
Consultants
- Dr. Jessop
- Panel
of Distinguished Scientific Consultants
- Mr. Peter
Probst
- Consultants in
Nuclear Medicine
- Vicor's Officers
and Consultants
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