Camptothecin - Analysis, Patent, Company, Data Sheet, Suppliers, Application, Risk, Report.

Camptothecin Analysis, Patent, Company, Data Sheet, Process, Technology, Suppliers, Report Primary Information Services Home. Alkaloids . Etoposide . Ordering Information. Contact
Project at a Glance	Contents on the CD ROM
Camptothecin (CPT) is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoiso- merase I (topo I). It was discovered in 1966 by M. E. Wall and M. C. Wani in systematic screening of natural products for anticancer drugs. Camptothecin was isolated from the bark and stem of Camptotheca acuminata (Camptotheca, Happy tree), a tree native to China. CPT showed remarkable anticancer activity in preliminary clinical trials but also low solubility and (high) adverse drug reaction. Camptothecins (CPT) are one of the most important alkaloids of the 21st century because of their clinical applications against cancer and HIV-I. CPT has a unique penta- cyclic ring structure which gives itself and its derivatives the necessary antitumour activity and such spatial configuration cannot be synthesized artificially. CPT inhibits the replica-tion of Human Immuno Deficiency Virus (HIV) in vitro and is also shown to be effective in the complete remission of lung, breast, uterine and cervical cancer. The molecular and cytotoxic effects of camptothecin on Plasmodium falciparum proven that it is an interesting target for new anti-malarial drug development Camptothecin affects the activity of the enzyme topoisomerase I, whose normal action is to cleave, unwind, and religate DNA. When camptothe- cin binds to topoiso- merase I, it will be able to cleave but not to religate DNA. Thereby, camptothecin causes single strand breaks in DNA. Camptothecins are among the most recently approved anticancer agents with two derivatives approved by the FDA: Camptosar® (Irinotecan hydrochloride; CPT-11) for advanced colo-rectal carcinomas and Hycamtin(Topotecan) for ovarian cancers. Both drugs are water-soluble derivatives of the parent natural alkaloid camptothecin. Camptothecin (CPT) has recently attracted increasing attention as a promising anticancer agent for a variety of tumors. But the clinical application is largely hampered by its extreme water insolubility and unpredictable side effect. It is essential to establish an efficient and safe protocol for the admi-nistration of CPT versus melanoma. At present, semisynthetic water-soluble camptothe- cin analogs, topotecan and irinotecan, are prescribed as clinical antitumor drugs through out the world. The worldwide market size of irinotecan / topotecan in 2003 was estimated at about US$1 billion. Worldwide sales for camptothecins exceeded $725.0 million in 2004.	General Information Camptothecin General Info Camptothecin Information Camptothecin Basic Info Company Company from China Company from USA Company from China Company from USA Company from China Company from India Company from Finland Company from China Company from USA Company from China Data Sheet Camptothecin from USA (+)-Camptothecin (+)-Camptothecin, 98% Camptothecin (+)-Camptothecin (S)-(+)-Camptothecin (S)-(+)-Camptothecin from USA Camptothecin from Woburn Camptothecin, Sodium Salt Product Camptothecin (S)-(+)-Camptothecin Camptothecin, 9-amino (S)-(+)-Camptothecin from USA Camptothecin from USA Camptothecin from Germany Camptothecin from USA Camptothecin Product List Consultancy Consultancy from China Consultancy from USA Suppliers Suppliers for Camptothecin Camptothecin Suppliers Camptothecin Indian Supplier Camptothecin Manufacturer's and Suppliers Camptothecin Supplier List Report & Market Recent Development in the Pharmacology of Camptothecins Camptothecin accumulation in Ophiorrhiza rugosa var. prostrata from northern Western Ghats Influence of Geographical and Climatic Conditions on Camptothecin Study Antiviral Action of Camptothecin Characterization of a Camptothecin-resistant Human DNA TopoisomeraseI Electrochemical Studies of Camptothecin Review Camptothecin: Current Perspectives Secretory Structures and Their Relationship to Accumulation of Camptothecin Patent Camptothecin complexes Camptothecin conjugates Camptothecin derivatives Synthesis of camptothecin and analogs thereof Polymer-bound camptothecin derivatives Process for producing camptothecin Methods for purifying camptothecin compounds Pharmaceutical compositions containing camptothecins Polymeric derivatives of camptothecins Water-soluble esters of camptothecin compounds Bioactive derivatives of camptothecin Process for isolation of anticancer agent camptothecin from Nothapodytes foetida Process for making camptothecin derivatives	Analysis Bioactivation of carbamate-based 20(S)-camptothecin prodrugs Synthesis of (+)-camptothecin Biosynthesis of Camptothecin. Camptothecin Induces Protein-linked DNA Breaks via Mammalian DNA Topoisomerase Computational Modeling of Interaction between Campto- thecin and DNA Base pairs Design and Synthesis of Water-Soluble Glucuronide Derivatives of Camptothecin for Cancer Prodrug Monotherapy Isolation and Quantification of Camptothecin from Nothapodyfes foefida Novel Camptothecin Derivatives Determination and quantification of camptothecin in an endophytic fungus by liquid chromatography RP-HPLC analysis for campto- thecin content in Nothapodytes nimmoniana, an endangered medicinal plant Application Camptothecin Delivery Methods Camptothecin Analog Overcomes Breast Cancer Resistance Camptothecin, an anti-cancer alkaloid Anti-tumor activity of N-trimethyl chitosan-encapsulated camptothecin in a mouse melanoma model Biosynthetic system of camptothecin: An anticancer plant product A novel non-toxic camptothecin formulation for cancer chemotherapy Preclinical Efficacy of the Camptothecin-Polymer Conjugate IT-101inMultiple Cancer Models Forskolin and Camptothecin Induce a 30 kDa Protein Associated with Melatonin Production in Y79 Human Retinoblastoma Cells Production Camptothecin production by in vitro cultures of Ophiorrhiza liukiuensis and O. kuroiwai Camptothecin production by precursor feeding, elicitation Permeabilization and two- phase culture Comparison of camptothecin production from intact plants and callus culture of Ophiorvhiza mungos Elicitation of Camptothecin Production in Cell Cultures of Camptotheca acuminata Camptothecin Production from In Vitro Cultures of Camptotheca acuminata Decne Multiple shoot culturesa viable alternative for camptothecin production Effect Effects of Caspase Inhibition on Camptothecin-Induced Apoptosis of HL-60 Cells Effects of the combination of camptothecin and doxorubicin or etoposide on rat glioma cells and camptothecin-resistant variants Effects of Camptothecin on the Breakage and Repair of DNA during the Cell Cycle Inhibitory effects of camptothecin Interferon Induction by Viruses and Polynucleofides: A Differential Effect of Camptothecin Toxicity Acute Toxicity of Camptothecin Molecular and cytotoxic effects of Camptothecin Evaluation of antimetastatic activity and systemic toxicity of camptothecin-loaded microspheres in mice injected with B16-F10 melanoma cells Increased Camptothecin Toxicity Induced in Mammalian Cells Molecular and cytotoxic effects of camptothecin Order the CD ROM
Primary Information Services 21 Murugappan St, SwamyNagar Ext2, Ullagaram, Chennai - 600091, India. Phone: 91 44 22421080 Email : informer@eth.net , primaryinfo@gmail.com Mobile numbers:9940043898, 9444008898 Fax : 91 44 22423753