Ergotamine Tartrate                                                                          Products , Msds, Production, Synthesis, Patents, Company Profiles, Suppliers, Report                                                                                                                         Primary Information Services                                                                                          
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Project at a Glance Contents on the CD ROM
  • Ergotamine Tartrate occurs as colorless crystals, or a white to pale yellowish white or grayish white, crystalline powder.
  • Ergotamine is an ergopeptine and part of the ergot family of alkaloids; it is structurally and biochemically closely related to ergoline. It possesses structural similarity to several neurotransmitters, and has biological activity as a vasoconstrictor.
  • The pharmacologic properties of Ergotamine Tartrate are complex; some of the pharmacologic actions are unrelated to each other; some actions are even mutually antagonistic.
  • Ergotamine is a secondary metabolite (natural product) and the principal alkaloid produced by the ergot fungus, Claviceps purpurea, and related fungi in the family Clavicipitaceae.
  • Ergometrine was not easily extractable with solvents due to its tendency to remain in the aqueous phase and, above all, because it was present in scarce quantities in the mixture of alkaloids produced by the Claviceps sclerotia
  • The ergot fungus Claviceps purpurea produces the medically important ergopeptines, which consist of a cyclol-structured tripeptide and D-lysergic acid linked by an amide bond.
  • Ergot peptide alkaloids, also called ergopeptines, are produced by Claviceps purpurea and consist of cyclol-structured tripeptides attached by amide linkage to D-lysergic acid.
  • Large-scale production of the ergot alkaloids in submerged culture has been confined solely to the commercially important lysergic acid types produced by Claviceps paspali (Arcamone et
    al. 1961) and C . purpure.
  • Ergotamine Tartrate reduces extracranial blood flow, decreases the amplitude of pulsations in the cranial arteries and decreases hyperperfusion of the basilar artery territory.
  • Ergotamine Tartrate usually only produces small elevations in blood pressure but it does increase peripheral vascular resistance and causes a decrease in blood flow to various organs.
  • Ergotamine is contraindicated in peripheral vascular disease (thromboangiitis obliterans, luetic arteritis, severe arteriosclerosis, thrombophlebitis, Raynaud's disease), coronary heart disease, hypertension, impaired hepatic or renal function, severe pruritus, and sepsis.
  • Ergotamine is an alpha adrenergic blocking agent with a direct stimulating effect on the smooth muscle of peripheral and cranial blood vessels and produces depression of central vasomotor centers.
  • Ergotamine can reproduce the peripheral vasoconstriction and gangrene which is a prominent feature of ergot poisoning; it is used therapeutically in cases of migraine
    to reduce the vasodilatation and excessive pulsation of the branches of the external carotid artery.
  • Due to its vasoconstrictive effect it can reduce cerebral flow, precipitate angina, produce myocardial infarction, or aggravate an intermittent claudication
  • The History of Ergot
  • Ergotamine Tartrate
  • Ergotamine Tartrate - Monograph
  • Ergotamine


  • Cafergot
  • Cafergot - Product
  • Ergomar
  • Medihaler Ergotamine
  • Methergine
  • Ergotamine Tartrate 2 mg Sublingual Tablets
  • Ergotamine tartrate/caffeine 2mg/100mg suppositories
  • Temigran
  • Vascular Headache Suppressants
  • Nasal Spray


  • Ergotamine tartrate
  • Material Safety Data Sheet for Ergotamine
  • Ergotamine Tartrate MSDS
  • Ergam


  • Treatment of the acute after-effects resulting from alcohol ingestion
  • Method for effecting withdrawal from drug dependency
  • Aerosol formulations containing P134a and particulate medicament
  • Method and compositions for effecting withdrawal from drug dependency
  • Medicaments
  • Treatment of female sexual dysfunction
  • Method and composition for treating migraine
  • Sustained release tablet formulations
  • Stabilized suppositories containing ergo-alkaloids
  • Prophylactic treatment of migraine


  • Large-scale Production of Clavine Alkaloids by CZaviceps fusiformis
  • D-Lysergyl Peptide Synthetase from the Ergot Fungus Claviceps purpurea
  • Production of Peptide Ergot Alkaloids in Submerged Culture by Three Isolates of Claviceps purpurea
  • Lysergic Acid Derivatives
  • Ergotamine Production in Submerged Culture and Physiology of Claviceps purpurea


  • Ergotamine for acute migraine
  • The effect of ergotamine and dihydroergotamine on cerebral blood flow in man
  • The use of Ergotamine Tartrate in Migraine
  • Reproductive hormonal responses to ergotamine and ergonovine in cows during the luteal phase of the estrous cycle
  • Ergotamine-induced lower extremity arterial vasospasm presenting as acute limb ischemia
  • Ergotamine Tartrate in Uterine Inertia
  • Ergotamine alters plasma concentrations of glucagon, insulin, cortisol, and triiodothyronine in cows
  • Biosynthesis of Ergotamine in Protoplasts of Claviceps puvpurea
  • Biosynthesis of Ergotamine by Claviceps purpurea (Fr.) Tul.
  • Buccal absorption of ergotamine
  • Effect of an acute ergotamine challenge on reproductive hormones in follicular phase heifers and progestin-treated cows
  • Anti - Inflammatory Effects of Ergotamine in Steers
  • The Ergot Alkaloids
  • Synthesis
  • Progress and Prospects of Ergot Alkaloid Research

Company Profiles

  • Company Profile
  • Company from Bulgaria
  • Company from China
  • Company from India
  • Company from Israel
  • Another Company from India
  • Company from Germany


  • List of Suppliers
  • Suppliers List
  • Indian Suppliers
  • Ergotamine Tartrate Suppliers


  • The Brotherhood of Eternal Love
  • Upper limb artery segmental occlusions due to chronic use of ergotamine
  • FDA orders halt to manufacture of unapproved ergotamine drugs
  • Gangrene Induced by Methysergide and Ergotamine
  • Unilateral Arm Ischemia Due to Ergotamine Tartrate
  • Low bioavailablity of Ergotamine Tartrate After Oral and Rectal Administration in Migraine
  • Multiplex lateral flow immunoassays for the detection of pyrrolizidine, tropane and ergot alkaloids
  • Companies Ordered to Stop Manufacturing and Selling Unapproved Illegal Ergotamine Drugs to Treat Migraine Headaches
  • Chemical Diversion and Synthetic Drug Manufacture
  • Ergotamine absorption and toxicity
  • Controlled Clinical Trial of Ergotamine Tartrate
  • Valvular Heart Disease Associated With Ergotamine


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