Ornithine
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- Ornithine is an amino acid that plays
a role in the urea cycle. Ornithine is abnormally acumulated in the
body in ornithine transcarbamylase deficiency.
- L-Ornithine is one of the products of
the action of the enzyme arginase on L-arginine, creating urea.
- Therefore, ornithine is a central part
of the urea cycle, which allows for the disposal of excess nitrogen.
- Ornithine is recycled and, in a
manner, is a catalyst. First, ammonia is converted into carbamoyl
phosphate which creates one half of urea.
- Ornithine is converted into a urea
derivative at the nitrogen by carbamoyl phosphate.
- Another nitrogen is added from
aspartate, producing the denitrogenated fumarate, and the resulting
arginine (a guanidinium compound) is hydrolysed back to ornithine,
producing urea.
- The nitrogens of urea come from
the ammonia and aspartate, and the nitrogen in ornithine remains
intact.
- The effects of varying dietary protein
intake, and of supplements of ornithine, arginine, lysine, and
proline on a patient with hyperornithinemia, hyperammonemia, and
homocitrullinuria were investigated in an attempt to understand the
condition.
- The homocitrulline excretion is
increased with increased dietary lysine, and also by increased
protein intake.
- Supplementary ornithine or arginine
lowers plasma ammonia levels and simultaneously decreases the
excretion of homocitrulline.
- A possible cause of this disease is a
defect in the transport of ornithine into the mitochondria. Arginine
supplements may be useful in the treatment of the condition.
- Ornithine increases the production and
excretion of Human Growth Hormone (HGH) and is responsible for
muscle build-up, decomposing fat and increased energy production.
- Ornithin is found mainly in meat and
fish, eggs and milk.
- When highly over dosed it can lead to
disturbances of the gastro intestinal tract. Children, growing
adolescents and diabetics should not supplement ornithine
excessively.
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General
- Ornithine transcarbamylase
- Ornithine
- Ornithine transcarbamylase
deficiency
- L-ornithine structure
- L-arginine1200 mgs
MSDS
- Advanced H-orn(Z)-oh
- 20/PK decarb br ornithineI 5ml
- Dl-ornithine hydrochloride, 99%
- L-ornithine hydrochloride
- L-ornithine hcl
- L-(+)-ornithine-hydrochloride
- L-ornithine monohydrochloride
- L-ornithine dihydrochloride
Products
- L-ornithine amino acid
- Arginine & ornithine 500/250mg -
250 Caps
- L-ornithine 500mg, 120 capsules
- L-onithine
- Ornithine vasotocin analog,[125]-ovta)
- Ornithine amino acid information
zest for life.
Patent
- Hair growth modification with
ornithine decarboxylase inhibitors
- Highly concentrated preparations of
dopa compounds
- Method for the preparation of salts
of l-ornithine
- Modulation of ornithine
decarboxylase expression
- Pharmaceutical composition for
treating and preventing diseases
- One Liver for Four Children: First
Clinical Series of Liver Cell Transplantation
- Ornithine and arginine salts of
branched chain keto acids and uses in treatment of hepatic and renal
disorder
Study
- Hyperammonaemic encephalopathy after
initiation of valproate therapy in unrecognised ornithine
- Kinetic mechanism of ornithine
hydroxylase (PvdA) from pseudomonas aeruginosa
- Ornithine transcarbamylase deficiency
presenting as encephalopathy
- Ornithinemia, hyperammonemia, and
homocitrullinuria
- Sequestered end products and enzyme
regulation
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Company profiles
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Market
- 2012 china ornithine market depth
survey
- Dl-ornithine hci(CAS 1069-31-4)
market research
- L-ornithine alpha ketoglutarate
- China’s L(+)-ornithine
hydrochloride Market Research
- Ornithine industry market
- Reportlinker adds dl-ornithine hci
(CAS 1069-31-4)
Report
- Brain mr Imaging in neonatal Hyperammonemic
encephalopathy resulting from proximal urea cycle
disorders
- Heterozygote ornithine
transcarbamylase deficiency presenting as symptomatic hyperammonemia
- Hyperammonemia with reduced
ornithine, citrulline, arginine and proline
- L-ornithine treatment
- Metacyc compound: n-acetyl-L-ornithine
- Ornithine decarboxylase activity in
L929 cells
Uses
- Decarboxylation test
- L-ornithine hcl side effect
- L-arginine-hcl L-ornithine-hcl
- L-ornithine amino acid supplement is a
powerful rejuvenator
- The structure of putrescine
transcarbamylase, a key catalyst for fermentative utilization of
agmatine
- Ornithine alpha ketoglutarate
Pancreatin and its uses with ornithine
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