Ornithine
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  • Ornithine is an amino acid that plays a role in the urea cycle. Ornithine is abnormally acumulated in the body in ornithine transcarbamylase deficiency.
  • L-Ornithine is one of the products of the action of the enzyme arginase on L-arginine, creating urea.
  • Therefore, ornithine is a central part of the urea cycle, which allows for the disposal of excess nitrogen.
  • Ornithine is recycled and, in a manner, is a catalyst. First, ammonia is converted into carbamoyl phosphate which creates one half of urea.
  • Ornithine is converted into a urea derivative at the  nitrogen by carbamoyl phosphate.
  • Another nitrogen is added from aspartate, producing the denitrogenated fumarate, and the resulting arginine (a guanidinium compound) is hydrolysed back to ornithine, producing urea.
  •  The nitrogens of urea come from the ammonia and aspartate, and the nitrogen in ornithine remains intact.
  • The effects of varying dietary protein intake, and of supplements of ornithine, arginine, lysine, and proline on a patient with hyperornithinemia, hyperammonemia, and homocitrullinuria were investigated in an attempt to understand the condition.
  • The homocitrulline excretion is increased with increased dietary lysine, and also by increased protein intake.
  • Supplementary ornithine or arginine lowers plasma ammonia levels and simultaneously decreases the excretion of homocitrulline.
  • A possible cause of this disease is a defect in the transport of ornithine into the mitochondria. Arginine supplements may be useful in the treatment of the condition.
  • Ornithine increases the production and excretion of Human Growth Hormone (HGH) and is responsible for muscle build-up, decomposing fat and increased energy production.
  • Ornithin is found mainly in meat and fish, eggs and milk.
  • When highly over dosed it can lead to disturbances of the gastro intestinal tract. Children, growing adolescents and diabetics should not supplement ornithine excessively.
     
General
  • Ornithine transcarbamylase
  • Ornithine
  • Ornithine transcarbamylase deficiency
  • L-ornithine structure
  • L-arginine1200 mgs

MSDS

  • Advanced H-orn(Z)-oh
  • 20/PK decarb br ornithineI 5ml
  • Dl-ornithine hydrochloride, 99%
  • L-ornithine hydrochloride
  • L-ornithine hcl
  • L-(+)-ornithine-hydrochloride
  • L-ornithine monohydrochloride
  • L-ornithine dihydrochloride

Products

  • L-ornithine amino acid
  • Arginine & ornithine 500/250mg - 250 Caps
  • L-ornithine 500mg, 120 capsules
  • L-onithine
  • Ornithine vasotocin analog,[125]-ovta)
  • Ornithine amino acid information zest for life.

Patent

  • Hair growth modification with ornithine decarboxylase inhibitors
  • Highly concentrated preparations of dopa compounds
  • Method for the preparation of salts of l-ornithine
  • Modulation of ornithine decarboxylase expression
  • Pharmaceutical composition for treating and preventing diseases
  • One Liver for Four Children: First Clinical Series of Liver Cell Transplantation
  • Ornithine and arginine salts of branched chain keto acids and uses in treatment of hepatic and renal disorder  

Study

  • Hyperammonaemic encephalopathy after initiation of valproate therapy in unrecognised ornithine
  • Kinetic mechanism of ornithine hydroxylase (PvdA) from pseudomonas aeruginosa
  • Ornithine transcarbamylase deficiency presenting as encephalopathy
  • Ornithinemia, hyperammonemia, and homocitrullinuria
  • Sequestered end products and enzyme regulation

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Suppliers
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Company profiles

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Market
  • 2012 china ornithine market depth survey
  • Dl-ornithine hci(CAS 1069-31-4) market research
  • L-ornithine alpha ketoglutarate
  • China’s L(+)-ornithine hydrochloride Market Research
  • Ornithine industry market
  • Reportlinker adds dl-ornithine hci (CAS 1069-31-4)

Report

  • Brain mr Imaging in neonatal Hyperammonemic encephalopathy resulting from proximal urea cycle disorders
  • Heterozygote ornithine transcarbamylase deficiency presenting as symptomatic hyperammonemia
  • Hyperammonemia with reduced ornithine, citrulline, arginine and proline
  • L-ornithine treatment
  • Metacyc compound: n-acetyl-L-ornithine
  • Ornithine decarboxylase activity in L929 cells

Uses

  • Decarboxylation test
  • L-ornithine hcl side effect
  • L-arginine-hcl L-ornithine-hcl
  • L-ornithine amino acid supplement is a powerful rejuvenator
  • The structure of putrescine transcarbamylase, a key catalyst for fermentative utilization of agmatine
  • Ornithine alpha ketoglutarate Pancreatin and its uses with ornithine
     

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