Polypeptides - Introduction, Functions, Patents, Process, Study, Company Profiles, Consultants, Reports

Polypeptides Introduction, Functions, Patents, Process, Study, Company Profiles, Consultants, Reports Primary Information Services Home. Amino Acid . Ordering Information. Contact
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Polypeptides are chains of amino acids. Proteins are made up of one or more polypeptide molecules. A polypeptide is a long, continuous, and unbranched peptide. Proteins consist of one or more polypeptides arranged in a biologically functional way and are often bound to cofactors, or other proteins. An amino acid polymer is known as a polypeptide. A polypeptide can be composed of 20 different possible monomers that can, in theory, be linked together in any imaginable order. In contrast to peptides, polypeptides function as hormones that trigger specific physiological processes. In humans, hormone secretions of polypeptides occur in the endocrine system through a series of glands distributed throughout the body. Polypeptide growth factors are a diverse group of hormone-like agents that regulate growth and differentiation through cell surface receptors. A potential solution to the conundrum of polypeptide hormone specificity has recently emerged in a series of articles detailing the intranuclear translocation and action of peptide ligands and their receptors, or fragments thereof. Acceptance of an intranuclear function for polypeptide ligands and their receptors, however, is not universal. This may be due to a lack of a larger perspective on the intranuclear action of all ligand/receptor complexes. Many of the concerns regarding the function of intranuclear polypeptide ligand/receptors can be addressed by examining the parallels that exist with other acknowledged signaling pathways. Despite the amount of technology developed for recombinant protein production, optimization of the expression strategy is often needed for a large number of proteins or peptides. Factors that need to be considered are production and recovery in sufficient yield of the active polypeptide. Peptide thioesters are versatile synthetic intermediates that are useful in polypeptide synthesis. For example, native chemical ligation using peptide thioesters as building blocks is a very useful and convenient method for polypeptide synthesis. The general chemical requirements for the synthesis of peptide involve the blocking of carboxyl group of one amino acid and the amino group of the second amino acid. Two methods for the synthesis of peptides are the ringopening polymerization (ROP) of amino acid N-carboxyanhydrides (NCAs) and solid-phase synthesis. Phage display is a powerful technology for engineering polypeptides that bind virtually any target, and also for in- vestigating the binding speci¢cities of natural protein ligand interaction The use of bacterially expressed peptide segments in combination with chemically synthesized ones as building blocks offers great potential as a route to the synthesis of a wide variety of polypeptides. Proopiomelanocortin (POMC) is the polypeptide precursor of ACTH. First discovered in anterior pituitary corticotroph cells, it has more recently been revealed to have many other physiological aspects. The utilisation of peptide synthesis technology in solving health problems of worldwide importance was mainly dictated by the desire to obtain stable products devoid of the various contaminants often seen in recombinant material (glycosylation variants, proteases, DNA, endotoxins) in record time and in reasonable quantities to perform preclinical testing.	Introduction Peptides and Polypeptides Polypeptides and Proteins Polypeptides Protein and Polypeptide Structure Peptide Functions Fold and function of polypeptide transport-associated domains responsible for delivering unfolded proteins to membranes Polypeptide growth factors: Structure, function and mechanism of action Function of the lectin domain of polypeptide N-acetylgalactosaminyltransferase A Major Light-Harvesting Polypeptide of Photosystem II Functions in Thermal Dissipation Multiple novel functions of lamina associated polypeptide 2α in striated muscle Caged peptides and proteins Novel Function of the Eukaryotic Polypeptide-Chain Releasing Factor 3 (eRF3/GSPT) in the mRNA Degradation Pathway Nuclear localization and function of polypeptide ligands and their receptors The Physiological functions Synthesis Chemical Synthesis of Peptides and Proteins New Strategies in Polypeptide and Antibody Synthesis A photoremovable ligation auxiliary for use in polypeptide synthesis Proteases for Industrial Applications Peptide bonds, polypeptides and proteins Polypeptide purification with Contichrom Synthesis of Polypeptides by Ring-Opening Polymerization of a-Amino Acid N-Carboxyanhydrides Self-Assembled Templates for Polypeptide Synthesis Chemical and physical characterization of a proline-rich polypeptide from sheep colostrum Solid Phase Peptide Synthesis Polypeptide synthesis using an expressed peptide as a building block via the thioester method Polypeptide synthesis - translation Polypeptide Synthesis in Simian Virus 5-Infected Cells In Vitro Synthesis of a Precursor to the Methionine-rich Polypeptide of the Zein Fraction of Corn Polypeptide Synthesis Technology Technology Summary: Antischistosomal Polypeptide Fusion Polypeptides That Inhibit Exocytosis Medicinal application of long synthetic peptide technology Polypeptide Multilayer Nanofilms in Drug Delivery New technologies to prolong life-time of peptide, protein and low-molecular-weight drugs in vivo A recombinant polypeptide extends the in vivo half-life of peptides and proteins in a tunable manner Company Profiles Company from Ambernath Company from California Company from China Company from Texas Consultants Consultant Company from Hungary Company from New York	Patents Polypeptide Cytokine polypeptides Antimicrobial polypeptides Natriuretic polypeptides Automated polypeptide synthesis apparatus polypeptides and polypeptide analogues In vitro synthesis of polypeptides by optimizing amino acid metabolism Method for synthesis of polypeptides in cell-free systems Phytase polypeptides Methods and compositions for controlled polypeptide synthesis Study Assignment of Two Mitochondrially Synthesized Polypeptides to Human Mitochondrial DNA and Their Use in the Study of Intracellular Mitochondrial Interaction The Estimation of Polypeptide Chain Molecular Weights by Gel Filtration in 6 M Guanidine Hydrochloride A Major Light-Harvesting Polypeptide of Photosystem II Functions in Thermal Dissipation Hydrogen-Tritium Exchange of the Random Chain Polypeptide Inhibition of Protein Synthesis by Polypeptide Antibiotics Islet Amyloid Polypeptide (IAPP) Transgenic Rodents as Models for Type 2 Diabetes A C-H…O Hydrogen Bond Stabilized Polypeptide Chain Reversal Motif at the C-terminus of Helices in Proteins Tissue Polypeptide-Specific Antigen (TPS) as Tumour Marker in Epithelial Ovarian Cancer Uniting Polypeptides with Sequence-Designed Peptides Application Production of Antiserum to Respiratory Syncytial Virus Polypeptides Bactericidal venom-based polypeptides for treatment of S. aureus skin infections & wound healing Application of Thermally Responsive Elastin-like Polypeptide Fused to a Lactoferrin-derived Peptide for Treatment of Pancreatic Cancer Elastin-like Polypeptides: Biomedical applications Polypeptides associated with Gliotoxin production in the Biocontrol Fungus Gliocladium Virens Applications of a peptide ligand for streptavidin Reports PolyPeptide Group Announces Plans to Expand GMP Manufacturing Facilities Building business in therapeutic peptides Polypeptide chain configurations in crystalline proteins Chacteriztion of a polypeptide associated with 10S DNA polymerase a purified from calf thymus using monoclonal antibody Report on Computerized Analysis of Polypeptides Resolved by 2D Electrophoresis Samples A vs B E¤cient phage display of polypeptides fused to the carboxy-terminus of the M13 gene-3 minor coat protein Isolated atrial amyloid contains atrial natriuretic peptide: a report of six cases Proopiomelanocortin, a polypeptide precursor with multiple functions: from physiology to pathological conditions Order the CD ROM Today
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