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Information @ a Glance


  • Thrombinase is a novel blood clot dissolving agent
  • Thrombolytic enzyme is referred to as Thrombinase having a molecular weight of 31,000 to 32,000
  • Uses: in the treatment of the cerebral thrombosis stroke, myocardial infarction, deep vein thrombosis and in the prevention of post-surgical adhesion.
  • The product has been cleared by Drug Controller General of India (DCGI) for Phase I clinical trials.
  • Thrombinase  is thrombin dissolving agent containing a fibrinolytic enzyme named as thrombinase, isolated, identified and purified for the first time from a Bacillus species
  • Bacillus is a genus of Gram-positive rod-shaped bacteria and a member of the division Firmicutes.
  • Many Bacillus species are able to secrete large quantities of enzymes. Bacillus amyloliquefaciens is a species of Bacillus that is the source of a natural antibiotic protein barnase (a ribonuclease), alpha amylase used in starch hydrolysis, the protease subtilisin used with detergents, and the BamH1 restriction enzyme used in DNA research
Background Information
  • Thrombin in physiology and clinical disease
  • Interaction of Bothrojaracin with Prothrombin
  • Prothrombinas
  • Plasminogen activator
  • Fibrinolytic enzyme system
  • Thromboprophylaxis
  • Thrombosisa and Thrombin
  • New anticoagulants


  • Production of thrombin
  • Production & purification thrombinase from Bacillus sphaericus
  • Production of Thrombin by the
    Prothrombinase Complex

Project Information

  • Technology Offer
  • Project contacts
  • Commercialization
Bacillus species
  • Identification of Bacillus species


  • Research Institute
  • Translational Research
  • Consultant - Scientist
  • Consultant


  • Process for the preparation of Thrombinase
  • Process of preparation of Thrombolytic enzyme
  • Novel thrombolytic enzyme and a process for its preparation
  • Thrombolytic enzyme and a process for its preparation


  • Medicinal Applications
  • Thrombolytic Therapy
  • Deep venous thrombosis
  • Antithrombotic and Thrombolytic Therapy

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