Phosphorylation
 Technology, MSDS, Process, Product, Videos, Consultancy, Report, Study, Uses
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Project at a Glance Contents on the CD ROM
  • Phosphorylation is the addition of a phosphate (PO43-) group to a protein or other organic molecule.
  •  Phosphorylation turns many protein enzymes on and off, thereby altering their function and activity.
  • It is the most essential post-translational modification of proteins, modulates proteins
    conformation, stability, trafficking, interaction and cellular dynamics and plasticity.
  • It changes the activity of important signaling proteins. By controlling the activity of these proteins, kinases control most cellular processes including metabolism, transcription, cell cycle progression, cell movement, apoptosis .
  • Phosphorylation is a fundamental covalent PTM that regulates the function,
    localization and binding specificity of target proteins.
    Protein Phosphorylation in particular plays a significant role in a wide range of cellular processes.
  • Its prominent role in biochemistry is the subject of a very large body of
    research (as of March 2012, the Medline database returns nearly 200,000 articles on the
    subject, largely on protein phosphorylation).
  • Reversible phosphorylation of proteins is an important regulatory mechanism that
    occurs in both prokaryotic and eukaryotic organisms.
  •  Phosphorylation
    on serine is the most common, followed by threonine. Tyrosine phosphorylation is
    relatively rare.
  • ATP, the "high-energy" exchange medium in the cell, is synthesized in the
    mitochondrion by addition of a third phosphate group to ADP in a process referred to as oxidative phosphorylation.
  • It is the most common mechanism of regulating protein function and transmitting signals throughout the cell. While phosphorylation has been observed in bacterial proteins, it is considerably more pervasive in eukaryotic cells. It is estimated that one-third of the proteins in the human proteome are substrates for phosphorylation at some point.
  • ATP is also synthesized by substrate-level
    phosphorylation during glycolysis.
  • Protein phosphorylation is the most ubiquitous post-translational modification (PTM), and plays important role in most of biological processes.
  • Identification of site-specific phosphorylated substrates is fundamental for
    understanding the molecular mechanisms of phosphorylation.
 General
  • Oxidative Phosphorylation.
  • Fact Sheet-Protein Phosphorylation.
  • Phosphorylation-Overview.
  • What is Phosphorylation?
  • How is Phosphorylation level determined?
  • Origins of Protein Phosphorylation.
  • Phosphorylation Site specificity.
  • Site Mapping-Phosphorylation.
  • Identification of Phosphorylation sites.
  • Phosphorylation of oligonucleotides.

MSDS

  • Chemical Phosphorylation reagent II.
  • Phosphorylation reaction buffer.
  • Phosphorylated paracetamol.
  • Phosphorylation reagent.

Products

  • Cymevene.
  • Ganciclovir.
  • Monoclonal Anti-Phosphotyrosine-Peroxidase Clone.
  • Survival marker: Signal stain phospho-Akt(Ser473) IHC detection kit.

Process

  • Calcium-dependent phosphorylation process control brain aromatase in quail.
  • Phosphorylation analysis by mass spectrometry.
  • Mobility shift detection of phosphorylated proteins.
  • A New method of phos-phorylation & synthesis of some phosphate esters of biological interest.
  • Phosphorylation and processing of the Quorum sensing molecule.
  • Kinetic Analysis of Multisite Phosphorylation.
  • ATP synthesis.
  • Synthesis and phosphorylation of chromatin associated proteins.
  • Quantitative methods for the analysis of protein phosphorylation.
  • Oxidative Phosphorylation.
  • Mechanism of Phosphorylation.

Consultancy

  • Consultancy from Canada.
  • Consultancy from New York.
  • Consultancy from China.

Videos

  • Oxidative Phosphorylation.
  • Phosphorylation Cascade-Signal Transduction Pathway.
  • Oxidative phosphorylation and Chemiosmosis.
  • Information about Phosphorylation.

Study

  • Studies on the phosphorylation and dephosphorylation reactions.
  • A Paxillin tyrosine phosphorylation switch regulates the assembly and form of cell-matrix adhesions.
  • Src kinase regulation by phosphorylation and dephosphorylation.
  • A model for a network of phosphorylation.
  • Histone H3 phosphorylation is required for initiation of mammalian chromosome.
  • Geometry of Multisite phosphorylation.
  • Site-specific phosphorylation dynamics in signaling networks.
  • Computational resources for protein phosphorylation.
  • Effect of protein phos-phorylation on the functional activity of photosystem2.
  • Estrogen receptor phos-phorylation.
  • Phosphorylation.

Report

  • Principles of protein phosphorylation.
  • Postsynaptic protein phosphorylation.
  • Anti-diabetic drugs inhibit obesity-linked phosphorylation.
  • Chloroplast protein phos-phorylation.
  • Multiplex assays for signal transduction research.
  • Protein phosphorylation antibody pair.
  • Approach to analysis of protein phosphorylation.
  • Phosphorylation reaction in protein kinase A.
  • Protein tyrosine phosphorylation in plants.

Uses

  • Phosphorylation at the interface.
  • Signal Transduction-Protein Phosphorylation.
  • Phosphorylation by alkaline phosphatase: use of the enzyme in cascade reactions.
  • Online literature mining tool for protein phosphorylation.
  • Investigation on ATP synthesis via oxidative phosphorylation .

 

 

 

 

 

 

 

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