Trifluoroacetic Acid                                                                                   Introduction, Products, Patents, Process, Study, Company Profiles, Reports                                                                                                                          Primary Information Services                                                                                       Home. Organic Acid . Trifluoroethanol . Ordering Information. Contact  

Project at a Glance Contents on the CD ROM
  • Trifluoroacetic acid (TFA) is the simplest stable perfluorinated carboxylic acid chemical compound, with the formula CF3CO2H. It is a strong carboxylic acid due to the influence of the electronegative trifluoromethyl group. TFA is almost 100,000-fold more acidic than acetic acid. TFA is widely used in organic chemistry.
  • TFA occurs naturally in sea water, but only in small concentrations (<200 ng/L). Therefore, TFA is prepared industrially by the electrofluorination of acetyl chloride and acetic anhydride, followed by hydrolysis of the resulting trifluoroacetyl fluoride.
  • TFA is the precursor to many other fluorinated compounds such as trifluoroacetic anhydride and 2,2,2-trifluoroethanol. It is a reagent used in organic synthesis because of a combination of convenient properties: volatility, solubility in organic solvents, and its strength as an acid. TFA is also less oxidizing than sulfuric acid but more readily available in anhydrous form than many other acids.
  • TFA is popularly used as a strong acid in peptide synthesis and other organic synthesis to remove the t-butoxycarbonyl protecting group.
  • Trifluoroacetic acid is widely used in the chemical industry in processes where it is either consumed or becomes part of a chemical waste stream.To assess the potential for a halocarbon to produce trifluoroacetic acid, it is necessary to quantify the yield of trifluoroacetyl halide in its gas phase oxidation mechanism.
  • TFA is used in ion pairing agent in liquid chromatography (HPLC) of organic compounds, particularly peptides and small proteins. TFA is a versatile solvent for NMR spectroscopy (for materials stable in acid). It is also used as a calibrant in mass spectrometry.
  • Both Acetic acid and Trifluoroacetic acid, similarly to formic acid, adsorb dissociatively on the TiO2(110) surface. Trifluoroacetic acid (or its deuterated analogue CF3COOD) is condensed by exposing the substrate to a volumetrically calibrated effusive outflow from a capillary located 7mm from the crystal.
  • Trifluoroethanoic acid or trifluoroacetic acid (TFA) is one of the strongest known organic acids and plays a significant role in several branches of chemistry owing to its strong acidity .  It is of particular interest as a solvent as, in addition to its strong acidity, it possesses a range of useful additional properties including small nucleophilicity, high anodic discharge potential and satisfactory affinity with other organic solvents.
  • Trifluoroacetic acid (TFA) is commonly used in the manufacturing process to release synthesized peptides from solid-phase resins. TFA or acetate is also used during
    reversed-phase HPLC purification of peptides. TFA is manufactured using acetate and fluoride as precursors, and residual levels of these compounds may be present whenever TFA is used.
  • Separation of TFA
  • How to Use Trifluoroacetic Acid
  • Trifluoroacetic Acid
  • Trifluoroacetic Acid - Intro


  • Perfluoroacetic acid
  • Trifluoroethanoic acid
  • Trifluoroacetic acid 100%
  • Trifluoroacetic acid - D
  • Trifluoroacetic Acid - Msds
  • Trifluoroacetic Acid (TFA)
  • Trifluoroacetic acid MSDS
  • Msds of  Trifluoroacetic Acid
  • Trifluoroacetic acid 2%


  • Process of making trifluoroacetic acid
  • Method of preparing trifluoroacetic acid from trichlorotrifluoroethane
  • Process for producing trifluoroacetic acid and trifluoroacetyl chloride
  • Process for preparing trifluoroacetic or trichloroacetic acid esters
  • Nitration of aromatics with nitrogen oxides in trifluoroacetic acid
  • Plasma etch with trifluoroacetic acid and derivatives


  • Trifluoroacetic acid
  • Mobile Phase Blends, OPTIMA LC/MS Grade
  • Trifluoroacetic Acid, Optima LC/MS Grade
  • Trifluoroacetic Acid Product
  • Reagent
  • Trifluoroacetic acid - Product Info
  • Trifluoroacetic Acid - Properties

Study and Synthesis

  • Fate of Trifluoroacetic Acid
  • Trifluroacetic Acid Synthesis
  • Accurate calculation of the pKa of trifluoroacetic acid using high-level ab initio calculations
  • Adsorption of acetic and trifluoroacetic acid on the TiO2
  • Analysis of trifluoroacetic acid
  • The Esterification of TFA
  • Kinetics data for reaction of alcohols with trifluoroacetic acid
  • Neolignan Aurein Rearrangement with Trifluoroacetic acid
  • Reactions in nanofilms of trifluoroacetic acid (CF3COOH) driven by low energy electrons
  • Recovery of trifluoroacetic acid from dilute aqueous solutions by reactive distillation
  • Replacement of Trifluoroacetic Acid with of Pediocin PA-1: a Structural Effect HCl in the Hydrophobic Purification Steps
  • Trifluoroacetic Acid as an Efficient Catalyst
  • Guidelines For The Use Of TFA In HPLC Methods Using Charged Aerosol Detection
  • Determination of Trifluoroacetic Acid (TFA) in Peptides
  • Special applications of fluorinated organic compounds
  • A Facile and Efficient Synthesis of N-aryl Imides Using Trifluoroacetic Acid
  • The Many Uses of Trifluoroacetic Acid

Company Profiles

  • Company from Belgium
  • Company from Canada
  • Company from China
  • Another Company from China
  • Another Company from China
  • Company from Europe
  • Company from New Jersey


  • Company from Belgium
  • Expert
  • Consultancy Service 
  • Company from  New York
  • Company from  USA


  • Suppliers List
  • Suppliers Catalog
  • Chinese Suppliers
  • Global Suppliers
  • Suppliers Worldwide

Turnkey Providers

  • Company from Delhi
  • Company from Massachusetts


  • Trifluoroacetic Acid and Trifluoroethanol
  • HPLC Standard Controls as a Requirement in Proteomics
  • Eliminate TFA and Improve Sensitivity of Peptide Analyses by LC/MS



Order the CD ROM Today

Primary Information Services
 21 Murugappan St, SwamyNagar Ext2, 
Ullagaram, Chennai - 600091, India.
 Phone: 91 44 22421080 
Email :,
Mobile numbers:9940043898, 9444008898  Fax : 91 44 22423753