Trifluoroacetic Acid
Introduction, Products,
Patents, Process, Study, Company Profiles, Reports
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- Trifluoroacetic acid (TFA)
is the simplest stable perfluorinated carboxylic acid chemical
compound, with the formula CF3CO2H. It is a strong carboxylic acid
due to the influence of the electronegative trifluoromethyl group.
TFA is almost 100,000-fold more acidic than acetic acid. TFA is
widely used in organic chemistry.
- TFA occurs naturally
in sea water, but only in small concentrations (<200 ng/L).
Therefore, TFA is prepared industrially by the electrofluorination
of acetyl chloride and acetic anhydride, followed by hydrolysis of
the resulting trifluoroacetyl fluoride.
- TFA is the precursor
to many other fluorinated compounds such as trifluoroacetic
anhydride and 2,2,2-trifluoroethanol. It is a reagent used in
organic synthesis because of a combination of convenient properties:
volatility, solubility in organic solvents, and its strength as an
acid. TFA is also less oxidizing than sulfuric acid but more readily
available in anhydrous form than many other acids.
- TFA is popularly used
as a strong acid in peptide synthesis and other organic synthesis to
remove the t-butoxycarbonyl protecting group.
- Trifluoroacetic acid
is widely used in the chemical industry in processes where it is
either consumed or becomes part of a chemical waste stream.To assess
the potential for a halocarbon to produce trifluoroacetic acid, it
is necessary to quantify the yield of trifluoroacetyl halide in its
gas phase oxidation mechanism.
- TFA is used in ion
pairing agent in liquid chromatography (HPLC) of organic compounds,
particularly peptides and small proteins. TFA is a versatile solvent
for NMR spectroscopy (for materials stable in acid). It is also used
as a calibrant in mass spectrometry.
- Both Acetic acid and
Trifluoroacetic acid, similarly to formic acid, adsorb
dissociatively on the TiO2(110) surface. Trifluoroacetic acid (or
its deuterated analogue CF3COOD) is condensed by exposing the
substrate to a volumetrically calibrated effusive outflow from a
capillary located 7mm from the crystal.
- Trifluoroethanoic acid
or trifluoroacetic acid (TFA) is one of the strongest known organic
acids and plays a significant role in several branches of chemistry
owing to its strong acidity . It is of particular interest as
a solvent as, in addition to its strong acidity, it possesses a
range of useful additional properties including small
nucleophilicity, high anodic discharge potential and satisfactory
affinity with other organic solvents.
- Trifluoroacetic acid (TFA)
is commonly used in the manufacturing process to release synthesized
peptides from solid-phase resins. TFA or acetate is also used during
reversed-phase HPLC purification of peptides. TFA is manufactured
using acetate and fluoride as precursors, and residual levels of
these compounds may be present whenever TFA is used.
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Introduction
-
Separation of TFA
- How to Use
Trifluoroacetic Acid
- Trifluoroacetic Acid
- Trifluoroacetic Acid -
Intro
Msds
- Perfluoroacetic acid
- Trifluoroethanoic acid
- Trifluoroacetic acid
100%
- Trifluoroacetic acid -
D
- Trifluoroacetic Acid -
Msds
- Trifluoroacetic
Acid (TFA)
- Trifluoroacetic acid
MSDS
- Msds of
Trifluoroacetic Acid
- Trifluoroacetic acid
2%
Patents
- Process of making
trifluoroacetic acid
- Method of preparing
trifluoroacetic acid from trichlorotrifluoroethane
- Process for producing
trifluoroacetic acid and trifluoroacetyl chloride
- Process for preparing
trifluoroacetic or trichloroacetic acid esters
- Nitration of aromatics
with nitrogen oxides in trifluoroacetic acid
- Plasma etch with
trifluoroacetic acid and derivatives
Products
- Trifluoroacetic acid
- Mobile Phase Blends,
OPTIMA LC/MS Grade
- Trifluoroacetic Acid,
Optima LC/MS Grade
- Trifluoroacetic Acid
Product
- Reagent
- Trifluoroacetic acid -
Product Info
- Trifluoroacetic Acid -
Properties
Study and
Synthesis
- Fate of
Trifluoroacetic Acid
- Trifluroacetic Acid
Synthesis
- Accurate calculation
of the pKa of trifluoroacetic acid using high-level ab initio
calculations
- Adsorption of acetic
and trifluoroacetic acid on the TiO2
- Analysis of
trifluoroacetic acid
- The Esterification of
TFA
- Kinetics data for
reaction of alcohols with trifluoroacetic acid
- Neolignan Aurein
Rearrangement with Trifluoroacetic acid
- Reactions in nanofilms
of trifluoroacetic acid (CF3COOH) driven by low energy electrons
- Recovery of
trifluoroacetic acid from dilute aqueous solutions by reactive
distillation
- Replacement of
Trifluoroacetic Acid with of Pediocin PA-1: a Structural Effect HCl
in the Hydrophobic Purification Steps
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Uses
- Trifluoroacetic Acid
as an Efficient Catalyst
- Guidelines For The Use
Of TFA In HPLC Methods Using Charged Aerosol Detection
- Determination of
Trifluoroacetic Acid (TFA) in Peptides
- Special applications
of fluorinated organic compounds
- A Facile and Efficient
Synthesis of N-aryl Imides Using Trifluoroacetic Acid
- The Many Uses of
Trifluoroacetic Acid
Company
Profiles
- Company from Belgium
- Company from Canada
- Company from China
- Another Company from
China
- Another Company from
China
- Company from Europe
- Company from New
Jersey
Consultants
- Company from Belgium
- Expert
- Consultancy Service
- Company from New
York
- Company from USA
Suppliers
- Suppliers List
- Suppliers Catalog
- Chinese Suppliers
- Global Suppliers
- Suppliers Worldwide
Turnkey
Providers
- Company from Delhi
- Company from
Massachusetts
Reports
- Trifluoroacetic Acid
and Trifluoroethanol
- HPLC Standard
Controls as a Requirement in Proteomics
- Eliminate TFA and
Improve Sensitivity of Peptide Analyses by LC/MS
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