Calcium Phosphate Cement                                                      
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Project at a Glance

Contents on the CD Rom

  • Calcium phosphate cements (CPCs) were prepared using mixtures of tetracalcium phosphate (TTCP) and dicalcium phosphate anhydrous (DCPA), with TTCP/ DCPA molar ratios of 1/1, 1/2, or 1/3, with the powder and water as the liquid.
  • CPC are made of one or several calcium phosphate (CaP) powders and an aqueous solution.
  • CPCs belong to the category of the low-temperature CaPs that are obtained by precipitation from an aqueous solution at or around room temperature.
  • Another calcium phosphate cement is also now available on the market in Europe: Calcibon® (Biomet-Merck). This cement is injectable and both animal and clinical studies have shown that it has appropriate mechanical properties which allow good results in the filling of cancellous bone defects.
  • Calcium phosphate cements (CPCs) typically harden following the combination of a powder and an aqueous liquid.
  • Calcium phosphate cements (CPCs) are the emerging class of bone substitute materials.
  • The principle of CPCs is the cementing action of acidic and basic calcium phosphate compounds on wetting with an aqueous medium.
  • Calcium phosphate cements control bleeding and are safe to use in osteoporotic sternums during open heart surgery.
  • Calcium phosphate cement (CPC) hardens in situ to form hydroxyapatite and has been used in dental and craniofacial restorative applications.
  • In dentistry calcium phosphate cements play a secondary role at the moment, although they often have excellent bone repair properties.
  • CPC’s have been widely used as a bone tissue engineering scaffold material due to its excellent osteoconductivity, however, in vivo resorption and tissue in growth is slow.
  • Calcium phosphate cement, when mixed with water, forms a paste that selfhardens to form resorbable hydroxyapatite with excellent osteoconductivity and bone-replacing capability.
  • Orthopedic technology is constantly
    evolving due to the continuous
    improvement of fracture fixation and rehabilitation methods.
  • Callos is a next generation calcium phosphate cement indicated for filling bony defects in cancellous bone.
  • This unique biologic cement provides immediate high compressive support where host bone has been compromised.
  • The use of a calcium phosphate cement is optimal as a filler for structurally important metaphyseal defects due to its high mechanical strength and ability to maintain that strength throughout the entire healing process.
  • Clinically, this calcium phosphate cement (CPC) decreases postoperative morbidity and promotes early return to function in human patients with fractures of the distal aspect of the radius.
  • Calcium phosphate cement (CPC) sets to form hydroxyapatite, a major component of mineral bone, and is gaining increasing interest in bone repair applications.
  • It has been nearly 30 years since LeGeros and Brown and Chow first developed calcium phosphate cements for biomedical applications.
  • Calcium phosphate cements (CPCs) belong to a very important class of biomaterials because of their potential to be utilized in the
    human body for bone repair and substitution.
  • Essentially, these applications stem from their associated biological and physiological properties - CPCs are highly bioactive, biocompatible and osteoconductive, i.e., cements are able to be resorbed by biological serum, allowing its progressive substitution by newly formed bone.
  • Use of a calcium phosphate cement for filling bone defects has many advantages over particulates or porous-solid blocks.
  • The tensile and compressive strengths of the calcium phosphate cement were low compared to other calcium phosphates.
  • Several calcium phosphate cements have been developed and have potential use in orthopedic field.
  • Of these different CPC, the type of precipitation furnishes a classification of the cement type: brushite, hydroxyapatite, calcium-deficient hydroxyapatite, or amorphous calcium phosphate.
  • The most common and important class of CPC is transformed into nanocrystalline hydroxyapatite (HA) during the setting reaction.
  • To compare percutaneous transpedicular vertebroplasty using calcium phosphate cement (CPC) versus conservative treatment for osteoporotic vertebral fractures.
  • The development of calcium phosphate cements started almost three decades ago with the formulation of in situ-setting calcium phosphate pastes for dental repair and restoration applications.
  • Self-hardened calcium phosphate cement possesses great biocompatibility and excellent osteoconductivity and has found a variety of applications, such as dental and craniofacial repairs, in the orthopaedic area.
  • Approximately there are 300,000 surgeries which use calcium phosphate bone cement for fracture fixation in the U.S annually.
  • Use of calcium phosphate cement offers the potential for resorption of the cement over time and replacement with new bone as a biological method to restore vertebral body mass and avoid potential thermal cord injury.
  • The most recent calcium phosphate cement to be introduced to the market is a-BSM from Etex Corp.
 Process
  • Preparation and characterization of bioceramics produced from
    calcium phosphate cements
  • Preparation and characterization of new self-setting calcium phosphate cements based on alkali containing orthophosphates
  • Dimensional Stability of a Calcium Phosphate Cement (CPC)
  • Fiber reinforced calcium phosphate cement
  • Molecular mechanism of
    crystallization impacting calcium phosphate cements
  • Preparation, Physical- Chemical Characterization, and Cytocompatibility of
    Polymeric Calcium Phosphate Cements
  • Preparation of macroporous calcium phosphate cement tissue engineering scaffold
  • Properties of Calcium Phosphate Cements With Different Tetracalcium Phosphate andDicalcium Phosphate Anhydrous Molar Ratios
  • Setting Reactions and Compressive Strengths of Calcium Phosphate Cements
  • Chitosan Containing Calcium Phosphate Cement: Preparation and Clinical Study
  • Calcium Phosphate Cements and of cement protein drug microparticle composites for bone tissue engineering

Functions

  • Calcium Phosphate Cement Augmentation of the Femoral Neck Defect Created After Dynamic Hip Screw Removal
  • The effects of calcium phosphate cement particles on osteoblast functions
  • Evaluation of Tendon Graft Fixation Using -BSM Calcium Phosphate Cement
  • Effects of Calcium Phosphate Cement on the Peripheral Nerve Fibers
  • Calcium phosphate cement augmentation of cancellous bone screws can compensate for the absence of cortical fixation
  • Phosphoserine-modified calcium phosphate cements: bioresorption and substitution
  • Ionic modification of calcium phosphate cement viscosity. Part I: hypodermic injection and strength improvement of apatite cement
  • Ionic modification of calcium phosphate cement viscosity. Part II: hypodermic injection and strength improvement of brushite cement
  • Calcium phosphate cement composites in revision hip replacement

Studies

  • Unstable trochanteric fractures augmented with calcium phosphate cement
  • In vitro ageing of brushite calcium phosphate cement
  • The resorbable calcium phosphate cement alpha BSM ina sheep tibia segmental defect
  • Injectable calcium phosphate cement as a bone graft material around peri-implant dehiscence defects: A dog study
  • Calcium phosphate cement: A New saviour for furcation perforation? - An in-vitro study
  • O-phospho-L-serine: a modulator of bone healing in calcium-phosphate cements
  • Efficiency of Three-Calcium Phosphate Cements in Combination with Bio-Glass for Tibia Bone Recovery in Dogs; Based on Histo-Morphological Evaluations
Patent
  • Calcium phosphate cement
  • Calcium phosphate cements comprising amorophous calcium phosphate
  • Calcium phosphate cement and calcium phosphate cement composition
  • Calcium phosphate bone cements
  • Injectable calcium phosphate cement
  • Porous calcium phosphate cement
  • Storage stable calcium phosphate cements
  • Calcium phosphate cement, use and preparation thereof
  • Calcium phosphate granular cement and method for producing same
  • Rapid-hardening calcium phosphate cement compositions
  • Resorbable bioactive calcium phosphate cement
  • Calcium phosphate cements comprising antimicrobial agents
  • Process for affecting the setting and working time of, bioresorbable calcium phosphate cements
  • Calcium phosphate cements comprising an osteoclastogenic agent
  • Calcium phosphate cements prepared from silicate solutions
  • Process for preparing a paste from calcium phosphate cement

Company Profiles

  • Company from California
  • Company from France
  • Company from USA

Consultancy

  • Consultancy from Canada
  • Consultancy from China
  • Consultancy from Texas
  • Consultancy from UK

Consultants from USA

  • Consultant 1
  • Consultant 2
  • Consultant 3
  • Consultant 4

Raw Material Suppliers

  • Anhydrous dicalcium phosphate suppliers
  • Selling leads of Anhydrous dicalcium phosphate
  • Exporters of calcium carbonate
  • Calcium carbonate suppliers
  • Tetracalcium phosphate suppliers

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Applications & Product
  • Calcium Phosphate Cements Improve Bone Density
    When Used in Osteoporotic Sternums
  • Pedicle Lesional Screws and Calcium Phosphate Cement in
    Acute Thoracolumbar Burst Fractures
  • Development of a nonrigid, durable calcium phosphate cement for use in periodontal bone repair
  • Optimising calcium phosphate cement formulations to widen clinical application
  • Radiographic and histologic evaluation of inta-articular calcium phosphate cement in a rabbit model
  • Biopolymer-containing calcium phosphate foam for bone regeneration
  • Calcium phosphate cements as bone drug delivery systems: A review
  • Calcium phosphate cements: Competitive drug carriers for the musculoskeletal system
  • Development of a fully injectable calcium phosphate cement for orthopedic and dental applications
  • The biomechanical evaluation of calcium phosphate cements for use in vertebroplasty
  • Callos® Calcium Phosphate Cement
  • CarriGen® Porous Bone Substitute

Analysis

  • Intrinsic porosity of calcium phosphate cements and its significance for drug delivery and tissue engineering applications
  • In vitro surface reaction layer formation and dissolution of calcium phosphate cement –
    bioactive glass composites
  • Dissolution Tests for Self-Setting Calcium Phosphate Cement-Containing
    Nifedipine
  • Fabrication of porous calcium phosphate cements using gelatin as porogen
  • Rational synthesis of a nanocrystalline calcium phosphate cement exhibiting rapid conversion to hydroxyapatite
  • Use of vaterite and calcite in forming calcium phosphate cement scaffolds

Properties

  • Polymeric-Calcium Phosphate Cement Composites-Material
    Properties: In Vitro and In Vivo Investigations
  • High strength phosphate cement using industrial byproduct ashes
  • Calcium phosphate cements
  • Fast Setting Calcium Phosphate
    Cement–Chitosan Composite:
    Mechanical Properties and
    Dissolution Rates
  • Frozen delivery of brushite calcium phosphate cements
  • Antimicrobial potency of alkali ion substituted calcium phosphate cements
  • Mechanical properties and in-vivo performance of calcium phosphate cement–chitosan fibre composite
  • Basic properties of calcium phosphate cement containing different concentrations of citric acid solution
  • O-phospho-L-serine modified calcium phosphate cements – material properties, in vitro and in vivo investigations

Characteristics

  • In Vivo Characteristics of Premixed Calcium Phosphate Cements When Implanted in Subcutaneous Tissues and Periodontal Bone Defects
  • In Vitro and in Vivo Characteristics of Fluorapatite-Forming Calcium
    Phosphate Cements
  • The Cytocompatibility and Early Osteogenic Characteristics of an Injectable Calcium Phosphate Cement
  • Modifications of a calcium phosphate cement with biomolecules—Influence on nanostructure, material, and biological properties

Technology

  • Callos -  Calcium Phosphate Cement
  • Evaluation of 2 Cement Techniques for Augmentation of Stripped 1.5mm Screw Sites in the Distal Metaphysis of Feline Radii
  • Percutaneous vertebroplasty for osteoporotic compression fractures using calcium phosphate
    cement
  • Evaluation of an osteoconductive resorbable calcium phosphate cement and polymethylmethacrylate for augmentation of orthopedic screws in the pelvis of canine cadavers
  • Short-fibre reinforcement of calcium phosphate bone cement

Report

  • The early report of application of calcium phosphate cement on anterior cervical intervertebral fusion
  • Use of calcium phosphate bone cement for fracture fixations in osteoporotic patients
  • Vertebroplasty using injectable calcium phosphate cement compared to polymethylmethacrylate in a unique canine vertebral body large defect model
  • Annual Report
  • Scientific materials macroporous resorbable cement
  • Comment on ‘‘Self-Hardening Microspheres of Calcium Phosphate Cement with Collagen for Drug Delivery and Tissue Engineering in
    Bone Repair’’

Suppliers

  • Calcium phosphate cement suppliers
  • Suppliers and manufacturers of Calcium Phosphate cement

Primary Information Services
 21 Murugappan St, SwamyNagar Ext2, 
Ullagaram, Chennai - 600091, India.
 Phone: 91 44 22421080 
Email : informer@eth.net
Mobile numbers:9940043898, 9444008898  Fax : 91 44 22423753